{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:24:01Z","timestamp":1787775841301,"version":"build-2784847793"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Atorvastatin (ATOR) has been reported to increase the risk for diabetes mellitus. Therefore, in the current study, we focused on studying the effect of ATOR on the structure of islets of Langerhans including their various cellular components as well as on glucose homeostasis. We detected a statistically significant increase (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05) in \u03b2-cell mass and percentage with a significant decrease in \u03b1-cell area and percentage in animals that received ATOR compared to control ones. In addition, a statistically significant increase (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05) in the \u03b2-cell proliferation was observed in the ATOR group with negligible change in expression of inflammatory cytokines of the islets. A significant downregulation in apoptosis alongside a significant upregulation in anti-apoptosis were detected in islets of animals treated with ATOR. Moreover, there was a significant impairment in various parameters of glucose homeostasis in the ATOR-treated group. Therefore, ATOR may induce insulin resistance-like state that was demarcated at cellular as well as at biochemical levels with little or no inflammatory response.\n                  <\/jats:p>","DOI":"10.4103\/jmau.jmau_41_21","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T14:10:20Z","timestamp":1726582220000},"page":"126-133","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Impaired Glucose Homeostasis Accompanies Cellular Changes in Endocrine Pancreas after Atorvastatin Administration"],"prefix":"10.4103","volume":"12","author":[{"given":"Ahmed A. M.","family":"Abdel-Hamid","sequence":"first","affiliation":[{"name":"Department of Anatomy, Taibah College of Medicine, Taibah University, Almadina Almonawara, Kingdom of Saudi Arabia"},{"name":"Department of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa El-Din L.","family":"Firgany","sequence":"additional","affiliation":[{"name":"Department of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt"},{"name":"Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"R1-20240921","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.mehy.2017.07.007","article-title":"Pleiotropic effects of metformin to rescue statin-induced muscle injury and insulin resistance:A proposed mechanism and potential clinical implications","volume":"107","author":"Carris","year":"2017","journal-title":"Med Hypotheses"},{"key":"R2-20240921","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.amjcard.2018.06.017","article-title":"Effect of pitavastatin compared with atorvastatin and rosuvastatin on new-onset diabetes mellitus in patients with acute myocardial infarction","volume":"122","author":"Choi","year":"2018","journal-title":"Am J Cardiol"},{"key":"R3-20240921","doi-asserted-by":"crossref","first-page":"e4906","DOI":"10.1097\/MD.0000000000004906","article-title":"Atorvastatin inhibits insulin synthesis by inhibiting the Ras\/Raf\/ERK\/CREB pathway in INS-1 cells","volume":"95","author":"Sun","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"R4-20240921","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1080\/21623945.2015.1024394","article-title":"Is immunity a mechanism contributing to statin-induced diabetes?","volume":"4","author":"Henriksbo","year":"2015","journal-title":"Adipocyte"},{"key":"R5-20240921","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11892-017-0837-8","article-title":"Diabetes secondary to treatment with statins","volume":"17","author":"Laakso","year":"2017","journal-title":"Curr Diab Rep"},{"key":"R6-20240921","doi-asserted-by":"crossref","first-page":"v1000","DOI":"10.12688\/f1000research.8629.1","article-title":"Statin-induced diabetes:Incidence, mechanisms, and implications","volume":"5","author":"Ganda","year":"2016","journal-title":"F1000Res"},{"key":"R7-20240921","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jcjd.2015.12.006","article-title":"Statin use and the risk for incident diabetes mellitus in patients with acute coronary syndrome after percutaneous coronary intervention:A population-based retrospective cohort study in Taiwan","volume":"40","author":"Lin","year":"2016","journal-title":"Can J Diabetes"},{"key":"R8-20240921","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.2174\/1381612811319270014","article-title":"Statin therapy and new-onset diabetes:Molecular mechanisms and clinical relevance","volume":"19","author":"Banach","year":"2013","journal-title":"Curr Pharm Des"},{"key":"R9-20240921","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/MOL.0000000000000172","article-title":"Statins and diabetes risk:How real is it and what are the mechanisms?","volume":"26","author":"Robinson","year":"2015","journal-title":"Curr Opin Lipidol"},{"issue":"Suppl 1","key":"R10-20240921","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/1475-2840-12-S1-S3","article-title":"Statin diabetogenicity:Guidance for clinicians","volume":"12","author":"Ray","year":"2013","journal-title":"Cardiovasc Diabetol"},{"key":"R11-20240921","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.2147\/TCRM.S117150","article-title":"Impact of statins on risk of new onset diabetes mellitus:A population-based cohort study using the Korean National Health Insurance claims database","volume":"12","author":"Lee","year":"2016","journal-title":"Ther Clin Risk Manag"},{"key":"R12-20240921","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s40256-016-0176-1","article-title":"Use of statins and the risk of incident diabetes:A retrospective cohort study","volume":"16","author":"Olotu","year":"2016","journal-title":"Am J Cardiovasc Drugs"},{"key":"R13-20240921","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3389\/fphar.2017.00372","article-title":"Statins and new-onset diabetes mellitus:LDL receptor may provide a key link","volume":"8","author":"Yu","year":"2017","journal-title":"Front Pharmacol"},{"key":"R14-20240921","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3109\/07435800.2014.952018","article-title":"The good and bad effects of statins on insulin sensitivity and secretion","volume":"39","author":"Muscogiuri","year":"2014","journal-title":"Endocr Res"},{"key":"R15-20240921","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.yexmp.2017.02.017","article-title":"Vascular and cellular changes accompany altered expression of angiopoietins in placenta of non-complicated ART pregnancies","volume":"102","author":"Abdel-Hamid","year":"2017","journal-title":"Exp Mol Pathol"},{"key":"R16-20240921","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/iep.12261","article-title":"Correlation between testicular mast cell count and spermatogenic epithelium in non-obstructive azoospermia","volume":"99","author":"Abdel-Hamid","year":"2018","journal-title":"Int J Exp Pathol"},{"key":"R17-20240921","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10735-016-9664-5","article-title":"Hydroxychloroquine hindering of diabetic isletopathy carries its signature on the inflammatory cytokines","volume":"47","author":"Abdel-Hamid","year":"2016","journal-title":"J Mol Histol"},{"key":"R18-20240921","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.acthis.2019.04.009","article-title":"Increased mast cell number is associated with a decrease in beta-cell mass and regeneration in type 2 diabetic rats","volume":"121","author":"Abdel-Hamid","year":"2019","journal-title":"Acta Histochemica"},{"key":"R19-20240921","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.aanat.2019.05.002","article-title":"Modulatory effect of empagliflozin on cellular parameters of endocrine pancreas in experimental pre-diabetes","volume":"224","author":"Abdel-Hamid","year":"2019","journal-title":"Annals of anatomy"},{"key":"R20-20240921","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/iep.12343","article-title":"Dysplastic urothelial changes accompany empagliflozin administration in urinary bladder of experimental diabetes","volume":"100","author":"Abdel-Hamid","year":"2019","journal-title":"Int J Exp Pathol"},{"key":"R21-20240921","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.acthis.2016.06.002","article-title":"Favorable outcomes of hydroxychloroquine in insulin resistance may be accomplished by adjustment of the endothelial dysfunction as well as the skewed balance of adipokines","volume":"118","author":"Abdel-Hamid","year":"2016","journal-title":"Acta Histochem"},{"key":"R22-20240921","doi-asserted-by":"crossref","first-page":"151533","DOI":"10.1016\/j.acthis.2020.151533","article-title":"Impact of liraglutide on microcirculation in experimental diabetic cardiomyopathy","volume":"122","author":"Abdelrazik Soliman","year":"2020","journal-title":"Acta Histochemica"},{"key":"R23-20240921","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1007\/s10620-016-4344-6","article-title":"Increased Proliferative Activity Accompanies the Local Inflammatory Response of Gastric Mucosa After Intragastric Balloon Insertion","volume":"61","author":"Atef","year":"2016","journal-title":"Digestive Diseases and Sciences"},{"key":"R24-20240921","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.acthis.2016.01.004","article-title":"Tubal cytokine changes accompany the epithelial atypia of letrozole-stimulated ovaries","volume":"118","author":"Abdel-Hamid","year":"2016","journal-title":"Acta histochemica"},{"key":"R25-20240921","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/iep.12196","article-title":"Reversal of tubo-ovarian atypical epithelial patterns after cessation of ovarian stimulation by letrozole","volume":"97","author":"Abdel-Hamid","year":"2016","journal-title":"International journal of experimental pathology."},{"key":"R26-20240921","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bcp.2011.10.003","article-title":"A novel long acting DPP-IV inhibitor PKF-275-055 stimulates b-cell proliferation resulting in improved glucose homeostasis in diabetic rats","volume":"83","author":"Akarte","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"R27-20240921","doi-asserted-by":"crossref","first-page":"161","DOI":"10.14310\/horm.2002.1196","article-title":"Relative iron \u201coverload\u201din offspring of patients with type 2 diabetes mellitus:A new component in the conundrum of insulin resistance syndrome?","volume":"2","author":"Psyrogiannis","year":"2003","journal-title":"Hormones (Athens)"},{"key":"R28-20240921","article-title":"Correlation between pancreatic mast cells and the low grade inflammation in adipose tissue of experimental prediabetes","author":"Abdel-Hamid","year":"2018","journal-title":"Acta Histochem"},{"key":"R29-20240921","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4103\/0976-500X.136097","article-title":"Statin induced diabetes and its clinical implications","volume":"5","author":"Aiman","year":"2014","journal-title":"J Pharmacol Pharmacother"},{"key":"R30-20240921","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s10735-015-9625-4","article-title":"Atorvastatin alleviates experimental diabetic cardiomyopathy by suppressing apoptosis and oxidative stress","volume":"46","author":"Abdel-Hamid","year":"2015","journal-title":"J Mol Histol"},{"key":"R31-20240921","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/HCO.0b013e3283470359","article-title":"Are statins diabetogenic?","volume":"26","author":"Sampson","year":"2011","journal-title":"Curr Opin Cardiol"},{"key":"R32-20240921","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1517\/14740338.2015.1096343","article-title":"Statins and their increased risk of inducing diabetes","volume":"14","author":"Agouridis","year":"2015","journal-title":"Expert Opin Drug Saf"},{"key":"R33-20240921","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.cjca.2012.03.021","article-title":"Statin use and the risk of incident diabetes mellitus:A review of the literature","volume":"28","author":"Colbert","year":"2012","journal-title":"Can J Cardiol"},{"key":"R34-20240921","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s10735-018-9801-4","article-title":"Favorable outcomes of metformin on coronary microvasculature in experimental diabetic cardiomyopathy","volume":"49","author":"Abdel-Hamid","year":"2018","journal-title":"J Mol Histol"},{"key":"R35-20240921","first-page":"393","article-title":"Research on the effect of statins on insulin secretion from pancreatic islet in rats and its mechanisms","volume":"50","author":"Chang","year":"2011","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"R36-20240921","doi-asserted-by":"crossref","first-page":"376570","DOI":"10.1155\/2014\/376570","article-title":"Effects of simvastatin on glucose metabolism in mouse MIN6 cells","volume":"2014","author":"Zhou","year":"2014","journal-title":"J Diabetes Res"}],"container-title":["Journal of Microscopy and Ultrastructure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jmau.jmau_41_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:43:49Z","timestamp":1787773429000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jmau.jmau_41_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,20]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jmau.jmau_41_21","relation":{},"ISSN":["2213-879X","2213-8803"],"issn-type":[{"value":"2213-879X","type":"print"},{"value":"2213-8803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,20]]},"assertion":[{"value":"2021-04-21","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}