{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:09:35Z","timestamp":1789391375024,"version":"build-2803163510"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The translocation: t (8;21), a\n                    <jats:italic toggle=\"yes\">RUNX1-RUNX1T1<\/jats:italic>\n                    fusion transcript is one of the most common chromosomal abnormality, seen in 5%\u201310% cases of acute myeloid leukemia (AML) and is associated with a favorable prognosis. The most frequent association is found with AML with maturation, that is FAB category AML-M2 (22%\u201350%), followed by AML-M1, and very rarely in other AMLs. We report a case of AML with monocytic differentiation (AML-M5) with t (8;21), which is a very unusual finding in AML-M5. Our case had characteristic morphological findings of AML-M2, however, it turned out to be AML-M5 on immunophenotyping. We highlight the presence of t (8;21) in AML-M5 wherein the patient did not achieve morphological remission at 29 days and succumbed to his illness, thus emphasizing on the unusual association and a food for thought for both the clinician and the hematologist to ponder that t (8;21) can be associated with monocytic differentiation and overall poor prognosis.\n                  <\/jats:p>","DOI":"10.4103\/jmau.jmau_53_23","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T04:48:06Z","timestamp":1693975686000},"page":"169-171","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Unusual Translocation in a Usual Leukemia: Follow-up from Diagnosis to Hematopoietic Stem Cell Transplant"],"prefix":"10.4103","volume":"14","author":[{"given":"Shilpi","family":"More","sequence":"first","affiliation":[{"name":"Department of Pathology, ESIC Medical College and Hospital, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Raychaudhuri","sequence":"additional","affiliation":[{"name":"Department of Pathology, ESIC Medical College and Hospital, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garima","family":"Dhull","sequence":"additional","affiliation":[{"name":"Department of Pathology, ESIC Medical College and Hospital, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tathagata","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Hematology, ESIC Medical College and Hospital, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,9,6]]},"reference":[{"key":"R1-20260914","first-page":"104631","article-title":"Acute myeloid leukemia with the t (8;21) translocation: Clinical consequences and biological implications","author":"Reikvam","year":"2011","journal-title":"J Biomed Biotechnol 2011"},{"key":"R2-20260914","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1182\/blood-2009-11-254441","article-title":"Refinement of cytogenetic classification in acute myeloid leukemia: Determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom medical research council trials","volume":"116","author":"Grimwade","year":"2010","journal-title":"Blood"},{"key":"R3-20260914","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.2147\/CMAR.S242479","article-title":"Genetic characterization and risk stratification of acute myeloid leukemia","volume":"12","author":"Pourrajab","year":"2020","journal-title":"Cancer Manag Res"},{"key":"R4-20260914","first-page":"109","article-title":"Identificaton of a translocation with quinacrine fluorescence in a patient with acute leukemia","volume":"16","author":"Rowley","year":"1973","journal-title":"Ann Genet"},{"key":"R5-20260914","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3904\/kjim.2003.18.1.13","article-title":"Prognostic value of AML 1\/ETO fusion transcripts in patients with acute myelogenous leukemia","volume":"18","author":"Cho","year":"2003","journal-title":"Korean J Intern Med"},{"key":"R6-20260914","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1309\/EM7KCQR4GLMHRCX4","article-title":"Prognostic impact of acute myeloid leukemia classification. Importance of detection of recurring cytogenetic abnormalities and multilineage dysplasia on survival","volume":"119","author":"Arber","year":"2003","journal-title":"Am J Clin Pathol"},{"key":"R7-20260914","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/modpathol.2008.92","article-title":"Acute myeloid leukemia harboring t (8;21)(q22;q22): A heterogeneous disease with poor outcome in a subset of patients unrelated to secondary cytogenetic aberrations","volume":"21","author":"Lin","year":"2008","journal-title":"Mod Pathol"},{"key":"R8-20260914","doi-asserted-by":"crossref","first-page":"4747","DOI":"10.1200\/JCO.2008.21.0674","article-title":"Acute myeloid leukemia with translocation (8;21) or inversion (16) in elderly patients treated with conventional chemotherapy: A collaborative study of the French CBF-AML intergroup","volume":"27","author":"Pr\u00e9bet","year":"2009","journal-title":"J Clin Oncol"},{"key":"R9-20260914","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1182\/blood.V99.10.3517","article-title":"A white blood cell index as the main prognostic factor in t (8;21) acute myeloid leukemia (AML): A survey of 161 cases from the French AML intergroup","volume":"99","author":"Nguyen","year":"2002","journal-title":"Blood"},{"key":"R10-20260914","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1182\/blood.V116.21.1707.1707","article-title":"Bone marrow cellularity is a single most important independent prognostic factor in AML patients with t (8;21)","volume":"116","author":"Shin","year":"2010","journal-title":"Blood"}],"container-title":["Journal of Microscopy and Ultrastructure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jmau.jmau_53_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:00:21Z","timestamp":1789390821000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jmau.jmau_53_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,6]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jmau.jmau_53_23","relation":{},"ISSN":["2213-879X","2213-8803"],"issn-type":[{"value":"2213-879X","type":"print"},{"value":"2213-8803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,6]]},"assertion":[{"value":"2023-04-21","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-21","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}