{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:38:48Z","timestamp":1786649928990,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Trisomy 13 is a clinically severe condition wherein has a median life expectancy of 7 to 10 days, approximately 90% of patients end up dying during the 1\n                    <jats:sup>st<\/jats:sup>\n                    year of life. Among surviving births, it is the third most prevalent trisomy. It is significant as it is tied to a variety of central nervous, cardiac, and circulatory systems, urogenital system malformations, as well as a low survival rate. The factors that contribute to a longer survival rate are not fully understood. However, several studies have found that some factors such as genetic translocations or mosaicism, race, and female gender improve survivability. We describe a 14-year-old female with mosaic Patau syndrome (47, XX + 13) who experienced life longer than usual.\n                  <\/jats:p>","DOI":"10.4103\/jmau.jmau_54_22","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T04:23:35Z","timestamp":1669868615000},"page":"35-39","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Multidisciplinary Intervention for Patau Syndrome Patient with Long-Term Survival: A Case Report of Single Institution-Based Detailed Clinical Management"],"prefix":"10.4103","volume":"13","author":[{"given":"Anas S.","family":"Alyazidi","sequence":"first","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, King Abdulaziz University and University of Jeddah, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Abdullah","family":"Alsubaie","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, King Abdulaziz University and University of Jeddah, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha K.","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, King Abdulaziz University and University of Jeddah, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waheeb Sami","family":"Aggad","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, King Abdulaziz University and University of Jeddah, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"R1-20260423","doi-asserted-by":"crossref","first-page":"101789.","DOI":"10.1016\/j.scr.2020.101789","article-title":"Generation of an induced pluripotent stem cell line from chorionic villi of a Patau syndrome spontaneous abortion","volume":"45","author":"Long","year":"2020","journal-title":"Stem Cell Res"},{"key":"R2-20260423","first-page":"e18346.","article-title":"A six-year-old child with mosaic trisomy 13","volume":"13","author":"Albar","year":"2021","journal-title":"Cureus"},{"key":"R3-20260423","doi-asserted-by":"crossref","first-page":"bcr0620114381","DOI":"10.1136\/bcr-06-2011-4381","article-title":"Longevity and Patau syndrome: What determines survival?","volume":"2012","author":"Peroos","year":"2012","journal-title":"BMJ Case Rep"},{"key":"R4-20260423","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1136\/adc.71.4.343","article-title":"Natural history of trisomy 13","volume":"71","author":"Wyllie","year":"1994","journal-title":"Arch Dis Child"},{"key":"R5-20260423","doi-asserted-by":"crossref","first-page":"e1762.","DOI":"10.1002\/mgg3.1762","article-title":"Mosaic proximal trisomy 13q and regular trisomy 13 in a female patient with long survival: Involvement of an incomplete trisomic rescue and a chromothripsis event","volume":"9","author":"Mor\u00e1n-Barroso","year":"2021","journal-title":"Mol Genet Genomic Med"},{"key":"R6-20260423","doi-asserted-by":"crossref","first-page":"E3547.","DOI":"10.3390\/ijms19113547","article-title":"Role of overexpressed transcription factor foxo1 in fatal cardiovascular septal defects in Patau syndrome: Molecular and therapeutic strategies","volume":"19","author":"Abuzenadah","year":"2018","journal-title":"Int J Mol Sci"},{"key":"R7-20260423","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s12013-012-9355-0","article-title":"Better prognosis in newborns with trisomy 13 who received intensive treatments: A retrospective study of 16 patients","volume":"63","author":"Tsukada","year":"2012","journal-title":"Cell Biochem Biophys"},{"key":"R8-20260423","first-page":"288","article-title":"Patau syndrome with a long survival. A case report","volume":"3","author":"Duarte","year":"2004","journal-title":"Genet Mol Res"},{"key":"R9-20260423","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/ajmg.a.31056","article-title":"Patau syndrome with a long survival (146 months): A clinical report and review of literature","volume":"140","author":"Iliopoulos","year":"2006","journal-title":"Am J Med Genet A"},{"key":"R10-20260423","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1001\/archpedi.1967.02090270118016","article-title":"Trisomy D1 in a 10-year-old girl. Normal neutrophils and fetal hemoglobin","volume":"114","author":"Marden","year":"1967","journal-title":"Am J Dis Child"},{"issue":"Pt 1","key":"R11-20260423","first-page":"91","article-title":"Trisomy 13 (Patau\u2019s syndrome): A rare case of survival into adulthood","volume":"34","author":"Singh","year":"1990","journal-title":"J Ment Defic Res"},{"key":"R12-20260423","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/00019605-200104000-00014","article-title":"Long-term survival in Patau syndrome","volume":"10","author":"Tunca","year":"2001","journal-title":"Clin Dysmorphol"},{"key":"R13-20260423","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1399-0004.1993.tb04426.x","article-title":"Trisomy 13 (Patau syndrome) with an 11-year survival","volume":"43","author":"Zoll","year":"1993","journal-title":"Clin Genet"},{"key":"R14-20260423","first-page":"919","article-title":"Long-term survival of full trisomy 13 in a 14 year old male: A case report","volume":"20","author":"Imataka","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"R15-20260423","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/ajmg.1320080207","article-title":"Long survival in trisomy-13-syndrome: 21 cases including prolonged survival in two patients 11 and 19 years old","volume":"8","author":"Redheendran","year":"1981","journal-title":"Am J Med Genet"},{"key":"R16-20260423","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ejmg.2008.03.004","article-title":"Patau syndrome with long survival in a case of unusual mosaic trisomy 13","volume":"51","author":"Fogu","year":"2008","journal-title":"Eur J Med Genet"},{"key":"R17-20260423","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1399-0004.1997.tb02499.x","article-title":"Three cases of trisomy 13 mosaicism and a review of the literature","volume":"51","author":"Delatycki","year":"1997","journal-title":"Clin Genet"},{"key":"R18-20260423","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/ajmg.1320100204","article-title":"Unusual mosaicism of de novo structural abnormalities and ocular anomalies in a male with 13 trisomy syndrome","volume":"10","author":"Reardon","year":"1981","journal-title":"Am J Med Genet"},{"key":"R19-20260423","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1002\/ajmg.a.35863","article-title":"Clinical features and prognosis of a sample of patients with trisomy 13 (Patau syndrome) from Brazil","volume":"161A","author":"Petry","year":"2013","journal-title":"Am J Med Genet A"},{"key":"R20-20260423","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.braindev.2014.10.007","article-title":"Epileptic spasms and early-onset photosensitive epilepsy in Patau syndrome: An EEG study","volume":"37","author":"Spagnoli","year":"2015","journal-title":"Brain Dev"}],"container-title":["Journal of Microscopy and Ultrastructure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jmau.jmau_54_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:00:07Z","timestamp":1786647607000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jmau.jmau_54_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jmau.jmau_54_22","relation":{},"ISSN":["2213-879X","2213-8803"],"issn-type":[{"value":"2213-879X","type":"print"},{"value":"2213-8803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,1]]},"assertion":[{"value":"2022-06-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-29","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}