{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:32:08Z","timestamp":1786649528628,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>A prevalent autoimmune condition affecting the thyroid gland known as Hashimoto\u2019s thyroiditis (HT) is linked to a higher chance of developing thyroid cancer, especially papillary thyroid carcinoma (PTC) and primary thyroid mucosal-associated lymphoid tissue lymphoma. It is extremely rare for follicular thyroid neoplasms whether adenoma or carcinoma to develop in conjunction with Hashimoto\u2019s disease. In this case report, a left thyroid lobe large nodule was diagnosed by US as TIRAD IV. Cytology using fine-needle aspiration was done, and the case was designated as Thy3f (suspicious of follicular neoplasm). The patient underwent total thyroidectomy, gross examination revealed a large capsulated left thyroid lobe nodule and histological examination revealed minimally invasive follicular carcinoma on a background of Hashimoto\u2019s disease. The nuclear features of PTC were focal and immunostaining for CK19 was focal and weak. Furthermore, HBME1 IHC was negative and Glypican3 IHC showed focal weak cytoplasmic staining. In conclusion, rather than PTC and lymphoma, HT could coexist with other forms of thyroid neoplasms as follicular carcinoma.<\/jats:p>","DOI":"10.4103\/jmau.jmau_61_22","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T04:23:35Z","timestamp":1669868615000},"page":"32-34","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Follicular Thyroid Carcinoma Arising in a Background of Hashimoto\u2019s Thyroiditis"],"prefix":"10.4103","volume":"13","author":[{"given":"Mona Abdelhamid","family":"Kora","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa M. Serag","family":"El-Dien","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa Gaber","family":"Abdou","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"R1-20260423","doi-asserted-by":"crossref","first-page":"101367.","DOI":"10.1016\/j.beem.2019.101367","article-title":"Hashimotos\u2019 thyroiditis: Epidemiology, pathogenesis, clinic and therapy","volume":"33","author":"Ragusa","year":"2019","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"R2-20260423","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1089\/ct.2019;31.333-335","article-title":"Hashimoto\u2019s thyroiditis is a risk factor for thyroid cancer","volume":"31","author":"Fish","year":"2019","journal-title":"Clin Thyroidology"},{"key":"R3-20260423","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jss.2019.07.025","article-title":"Increased incidental thyroid cancer in patients with subclinical chronic lymphocytic thyroiditis","volume":"245","author":"Jackson","year":"2020","journal-title":"J Surg Res"},{"key":"R4-20260423","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.3109\/0284186X.2011.602109","article-title":"Clinical relationship between Hashimoto\u2019s thyroiditis and papillary thyroid cancer","volume":"50","author":"Ahn","year":"2011","journal-title":"Acta Oncol"},{"key":"R5-20260423","first-page":"3076","article-title":"Concomitant papillary thyroid carcinoma and mucosa-associated lymphoid tissue thyroid lymphoma in the setting of Hashimoto thyroiditis","volume":"11","author":"Lan","year":"2018","journal-title":"Int J Clin Exp Pathol"},{"key":"R6-20260423","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1530\/EJE-11-0499","article-title":"RET\/PTC rearrangement in benign and malignant thyroid diseases: A clinical standpoint","volume":"165","author":"Marotta","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"R7-20260423","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/his.13380","article-title":"Molecular pathology of thyroid tumours of follicular cells: A review of genetic alterations and their clinicopathological relevance","volume":"72","author":"Acquaviva","year":"2018","journal-title":"Histopathology"},{"key":"R8-20260423","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1097\/00000478-199812000-00008","article-title":"Follicular and hurthle cell carcinomas of the thyroid: A comparative study","volume":"22","author":"Evans","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"R9-20260423","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/pin.12737","article-title":"The new 4th edition World Health Organization classification for thyroid tumors, Asian perspectives","volume":"68","author":"Kakudo","year":"2018","journal-title":"Pathol Int"},{"key":"R10-20260423","doi-asserted-by":"crossref","first-page":"20180014","DOI":"10.1259\/bjr.20180014","article-title":"Thyroid nodules and cancer in children and adolescents affected by Hashimoto\u2019s thyroiditis","volume":"91","author":"Won","year":"2018","journal-title":"Br J Radiol"},{"key":"R11-20260423","doi-asserted-by":"crossref","first-page":"26.","DOI":"10.1186\/s12902-019-0351-x","article-title":"Association between Hashimoto\u2019s thyroiditis and papillary thyroid carcinoma: A retrospective analysis of 305 patients","volume":"19","author":"Graceffa","year":"2019","journal-title":"BMC Endocr Disord"}],"container-title":["Journal of Microscopy and Ultrastructure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jmau.jmau_61_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:55:03Z","timestamp":1786647303000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jmau.jmau_61_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jmau.jmau_61_22","relation":{},"ISSN":["2213-879X","2213-8803"],"issn-type":[{"value":"2213-879X","type":"print"},{"value":"2213-8803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,1]]},"assertion":[{"value":"2022-07-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}