{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:05:01Z","timestamp":1792037101008,"version":"4.4.0"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Quercetin is a flavonoid, with antioxidant and autophagy-modulating activities. Cisplatin is one of the platinum-based anticancer drugs. Early development of peripheral neuropathy as an adverse effect of cisplatin interferes with the continuation of therapy. Oxidative stress and autophagy impairment may play a role.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This study aimed to explore the possible protective effects of quercetin against cisplatin-induced peripheral neuropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty-four male Wistar rats were divided into three groups: Group 1 (control group) and Group 2 (cisplatin group) where peripheral neuropathy was induced using single ip injection of cisplatin. Group 3 (cisplatin + quercetin group) received single ip injection of cisplatin and was then treated with quercetin for 14 days. At the end of the experiment, nociception was evaluated by tail immersion test, and then, blood was collected for analysis of nerve growth factor. Sciatic nerve was used to assess histopathological changes and light chain 3-II by immunohistochemical staining. Reduced glutathione, malondialdehyde, mTOR, and caspase-3 were estimated in sciatic nerve tissue homogenate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>This research work revealed that quercetin significantly improved cisplatin-induced nociceptive impairment, attenuated cisplatin-induced oxidative stress, autophagy, and apoptosis to protect against neuronal death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>From the current study, quercetin can act as a promising protective agent against cisplatin-induced peripheral neuropathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jmau.jmau_78_22","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T09:10:15Z","timestamp":1683623415000},"page":"107-114","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Targeting Oxidative Stress, Autophagy, and Apoptosis by Quercetin to Ameliorate Cisplatin-induced Peripheral Neuropathy in Rats"],"prefix":"10.4103","volume":"11","author":[{"given":"Heba A.","family":"Mahmoud","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemat E. El","family":"Horany","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt"},{"name":"Department of Biochemistry, College of Medicine, Hail University, Hail, Dammam, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Aboalsoud","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania Nagi.","family":"Abd-Ellatif","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal Ahmed El","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alshimaa","family":"Aboalsoud","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"R1-20240830","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/187152007779314044","article-title":"Biochemical mechanisms of cisplatin cytotoxicity","volume":"7","author":"Cepeda","year":"2007","journal-title":"Anticancer Agents Med Chem"},{"key":"R2-20240830","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrd1691","article-title":"Cellular processing of platinum anticancer drugs","volume":"4","author":"Wang","year":"2005","journal-title":"Nat Rev Drug Discov"},{"key":"R3-20240830","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1080\/02841860902806609","article-title":"Persistent neuropathy after treatment with cisplatin and oxaliplatin","volume":"48","author":"Brouwers","year":"2009","journal-title":"Acta Oncol"},{"key":"R4-20240830","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3389\/fnins.2015.00131","article-title":"Mechanisms of chemotherapy-induced behavioral toxicities","volume":"9","author":"Vichaya","year":"2015","journal-title":"Front Neurosci"},{"key":"R5-20240830","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.3390\/ijms20061451","article-title":"Mechanisms of chemotherapy-induced peripheral neuropathy","volume":"20","author":"Zaj\u0105czkowska","year":"2019","journal-title":"Int J Mol Sci"},{"key":"R6-20240830","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/030089160509100206","article-title":"A pilot study on the effect of acetyl-L-carnitine in paclitaxel- and cisplatin-induced peripheral neuropathy","volume":"91","author":"Maestri","year":"2005","journal-title":"Tumori"},{"key":"R7-20240830","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ejphar.2011.06.051","article-title":"Abrogation of cisplatin-induced nephrotoxicity in mice by alpha lipoic acid through ameliorating oxidative stress and enhancing gene expression of antioxidant enzymes","volume":"668","author":"El-Beshbishy","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"R8-20240830","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1039\/C5FO00624D","article-title":"Curcumin prevents cisplatin-induced decrease in the tight and adherens junctions:Relation to oxidative stress","volume":"7","author":"Trujillo","year":"2016","journal-title":"Food Funct"},{"key":"R9-20240830","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/s41419-018-0888-z","article-title":"Evaluating protective and therapeutic effects of alpha-lipoic acid on cisplatin-induced ototoxicity","volume":"9","author":"Kim","year":"2018","journal-title":"Cell Death Dis"},{"key":"R10-20240830","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3390\/cancers3011351","article-title":"Cisplatin as an anti-tumor drug:Cellular mechanisms of activity, drug resistance and induced side effects","volume":"3","author":"Florea","year":"2011","journal-title":"Cancers (Basel)"},{"key":"R11-20240830","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/s41419-018-1192-7","article-title":"Calcimimetic restores diabetic peripheral neuropathy by ameliorating apoptosis and improving autophagy","volume":"9","author":"Chung","year":"2018","journal-title":"Cell Death Dis"},{"key":"R12-20240830","doi-asserted-by":"crossref","first-page":"E8072","DOI":"10.1073\/pnas.1710566114","article-title":"Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury","volume":"114","author":"Brosius Lutz","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R13-20240830","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1083\/jcb.201503019","article-title":"Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves","volume":"210","author":"Gomez-Sanchez","year":"2015","journal-title":"J Cell Biol"},{"key":"R14-20240830","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41467-017-00689-z","article-title":"Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease","volume":"8","author":"L\u00fcningschr\u00f6r","year":"2017","journal-title":"Nat Commun"},{"key":"R15-20240830","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.2741\/4467","article-title":"The impact of autophagy on peripheral synapses in health and disease","volume":"21","author":"Rudolf","year":"2016","journal-title":"Front Biosci (Landmark Ed)"},{"key":"R16-20240830","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.brainres.2013.04.055","article-title":"Expression of LC3 and Beclin 1 in the spinal dorsal horn following spinal nerve ligation-induced neuropathic pain","volume":"1519","author":"Zhang","year":"2013","journal-title":"Brain Res"},{"key":"R17-20240830","doi-asserted-by":"crossref","first-page":"e0148792","DOI":"10.1371\/journal.pone.0148792","article-title":"Galectin-3 inhibition is associated with neuropathic pain attenuation after peripheral nerve injury","volume":"11","author":"Ma","year":"2016","journal-title":"PLoS One"},{"key":"R18-20240830","doi-asserted-by":"crossref","first-page":"11388","DOI":"10.1523\/JNEUROSCI.1356-10.2010","article-title":"Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice","volume":"30","author":"Rangaraju","year":"2010","journal-title":"J Neurosci"},{"key":"R19-20240830","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/ki.2013.559","article-title":"Rictor\/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury","volume":"86","author":"Li","year":"2014","journal-title":"Kidney Int"},{"key":"R20-20240830","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/ki.2012.261","article-title":"Autophagy in proximal tubules protects against acute kidney injury","volume":"82","author":"Jiang","year":"2012","journal-title":"Kidney Int"},{"key":"R21-20240830","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3389\/fncel.2018.00515","article-title":"Sirtuin 1 and autophagy attenuate cisplatin-induced hair cell death in the mouse cochlea and zebrafish lateral line","volume":"12","author":"Pang","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"R22-20240830","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.biopha.2017.07.145","article-title":"Quercetin alleviates thermal and cold hyperalgesia in a rat neuropathic pain model by inhibiting Toll-like receptor signaling","volume":"94","author":"Ji","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"R23-20240830","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/13813455.2019.1671458","article-title":"Autophagy as a molecular target of quercetin underlying its protective effects in human diseases","volume":"128","author":"Ashrafizadeh","year":"2022","journal-title":"Arch Physiol Biochem"},{"key":"R24-20240830","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s10571-014-0070-9","article-title":"Anti-apoptotic and anti-oxidative roles of quercetin after traumatic brain injury","volume":"34","author":"Yang","year":"2014","journal-title":"Cell Mol Neurobiol"},{"key":"R25-20240830","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/sc.2015.227","article-title":"Quercetin suppresses NLRP3 inflammasome activation and attenuates histopathology in a rat model of spinal cord injury","volume":"54","author":"Jiang","year":"2016","journal-title":"Spinal Cord"},{"key":"R26-20240830","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neuropharm.2016.04.032","article-title":"Quercetin stabilizes apolipoprotein E and reduces brain Ab levels in amyloid model mice","volume":"108","author":"Zhang","year":"2016","journal-title":"Neuropharmacology"},{"key":"R27-20240830","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s00701-016-2761-0","article-title":"Effects of quercetin on chronic constriction nerve injury in an experimental rat model","volume":"158","author":"\u00c7ivi","year":"2016","journal-title":"Acta Neurochir (Wien)"},{"key":"R28-20240830","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4155\/fmc-2016-0186","article-title":"Quercetin and derivatives:Useful tools in inflammation and pain management","volume":"9","author":"Carullo","year":"2017","journal-title":"Future Med Chem"},{"key":"R29-20240830","first-page":"285708","article-title":"Quercetin reduces Ehrlich tumor-induced cancer pain in mice","volume":"2015","author":"Calixto-Campos","year":"2015","journal-title":"Anal Cell Pathol (Amst)"},{"key":"R30-20240830","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1177\/0748233713483192","article-title":"Hesperidin protects brain and sciatic nerve tissues against cisplatin-induced oxidative, histological and electromyographical side effects in rats","volume":"31","author":"Kamisli","year":"2015","journal-title":"Toxicol Ind Health"},{"key":"R31-20240830","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/jbt.21821","article-title":"Ameliorative effect of quercetin on neurochemical and behavioral deficits in rotenone rat model of parkinson's disease:Modulating autophagy (Quercetin on Experimental Parkinson's Disease)","volume":"30","author":"El-Horany","year":"2016","journal-title":"J Biochem Mol Toxicol"},{"key":"R32-20240830","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"R33-20240830","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.npep.2019.03.005","article-title":"Autophagy dysfunction in neuropathic pain","volume":"75","author":"Liu","year":"2019","journal-title":"Neuropeptides"},{"key":"R34-20240830","doi-asserted-by":"crossref","first-page":"214","DOI":"10.4103\/2231-0738.139402","article-title":"Neuroprotective effect of ethyl pyruvate in vincristine and cisplatin induced neuropathic pain","volume":"4","author":"Bansode","year":"2014","journal-title":"Int J Nutr Pharmacol Neurol Dis"},{"key":"R35-20240830","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/ame2.12070","article-title":"Allantoin attenuates deficits of behavioural and motor nerve conduction in an animal model of cisplatin-induced neurotoxicity in rats","volume":"2","author":"Vindya","year":"2019","journal-title":"Animal Model Exp Med"},{"key":"R36-20240830","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.neuro.2012.09.011","article-title":"Curcumin reduces cisplatin-induced neurotoxicity in NGF-differentiated PC12 cells","volume":"34","author":"Mendon\u00e7a","year":"2013","journal-title":"Neurotoxicology"},{"key":"R37-20240830","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1179\/1743132815Y.0000000079","article-title":"Naringenin neutralises oxidative stress and nerve growth factor discrepancy in experimental diabetic neuropathy","volume":"37","author":"Al-Rejaie","year":"2015","journal-title":"Neurol Res"},{"key":"R38-20240830","first-page":"3140","article-title":"Tanshinone IIA ameliorates oxaliplatin-induced neurotoxicity via mitochondrial protection and autophagy promotion","volume":"11","author":"Cheng","year":"2019","journal-title":"Am J Transl Res"},{"key":"R39-20240830","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.nut.2012.11.007","article-title":"Effects of olive polyphenols administration on nerve growth factor and brain-derived neurotrophic factor in the mouse brain","volume":"29","author":"De Nicol\u00f3","year":"2013","journal-title":"Nutrition"},{"key":"R40-20240830","doi-asserted-by":"crossref","first-page":"127075","DOI":"10.1155\/2013\/127075","article-title":"Flavonoids induce the synthesis and secretion of neurotrophic factors in cultured rat astrocytes:A signaling response mediated by estrogen receptor","volume":"2013","author":"Xu","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"R41-20240830","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.sjbs.2016.11.017","article-title":"Neuroprotective effects of quercetin in diabetic rat retina","volume":"24","author":"Ola","year":"2017","journal-title":"Saudi J Biol Sci"},{"key":"R42-20240830","doi-asserted-by":"crossref","first-page":"(3)","DOI":"10.1111\/jpi.12393","article-title":"Melatonin prevents mitochondrial dysfunction and promotes neuroprotection by inducing autophagy during oxaliplatin-evoked peripheral neuropathy","volume":"62","author":"Areti","year":"2017","journal-title":"J Pineal Res"},{"key":"R43-20240830","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3390\/ijms20030728","article-title":"Balancing mTOR signaling and autophagy in the treatment of Parkinson's disease","volume":"20","author":"Zhu","year":"2019","journal-title":"Int J Mol Sci"},{"key":"R44-20240830","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12990-015-0030-5","article-title":"mTOR, a new potential target for chronic pain and opioid-induced tolerance and hyperalgesia","volume":"11","author":"Lutz","year":"2015","journal-title":"Mol Pain"},{"key":"R45-20240830","doi-asserted-by":"crossref","first-page":"52923","DOI":"10.18632\/oncotarget.17629","article-title":"Effect and mechanism of inhibition of PI3K\/Akt\/mTOR signal pathway on chronic neuropathic pain and spinal microglia in a rat model of chronic constriction injury","volume":"8","author":"Guo","year":"2017","journal-title":"Oncotarget"},{"key":"R46-20240830","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1139\/cjpp-2019-0156","article-title":"Effects of inhibiting the PI3K\/Akt\/mTOR signaling pathway on the pain of sciatic endometriosis in a rat model","volume":"97","author":"Liu","year":"2019","journal-title":"Can J Physiol Pharmacol"},{"key":"R47-20240830","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41586-019-0969-x","article-title":"The single-cell transcriptional landscape of mammalian organogenesis","volume":"566","author":"Cao","year":"2019","journal-title":"Nature"},{"key":"R48-20240830","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jchemneu.2017.12.011","article-title":"Lycium barbarum polysaccharide protects diabetic peripheral neuropathy by enhancing autophagy via mTOR\/p70S6K inhibition in Streptozotocin-induced diabetic rats","volume":"89","author":"Liu","year":"2018","journal-title":"J Chem Neuroanat"},{"key":"R49-20240830","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/path.2694","article-title":"Autophagy:Assays and artifacts","volume":"221","author":"Barth","year":"2010","journal-title":"J Pathol"},{"key":"R50-20240830","doi-asserted-by":"crossref","first-page":"8797","DOI":"10.12659\/MSM.918536","article-title":"PTEN-induced putative kinase 1 (PINK1)\/parkin-mediated mitophagy protects PC12 cells against cisplatin-induced neurotoxicity","volume":"25","author":"Zhang","year":"2019","journal-title":"Med Sci Monit"},{"key":"R51-20240830","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neulet.2018.06.027","article-title":"Low-dose cisplatin causes growth inhibition and loss of autophagy of rat astrocytes in vitro","volume":"682","author":"Jiang","year":"2018","journal-title":"Neurosci Lett"},{"key":"R52-20240830","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neulet.2015.05.046","article-title":"Increased autophagic activity in dorsal root ganglion attenuates neuropathic pain following peripheral nerve injury","volume":"599","author":"Guo","year":"2015","journal-title":"Neurosci Lett"},{"key":"R53-20240830","doi-asserted-by":"crossref","first-page":"104626","DOI":"10.1016\/j.phrs.2019.104626","article-title":"Therapeutic potential of polyphenols in cardiovascular diseases:Regulation of mTOR signaling pathway","volume":"152","author":"Sanches-Silva","year":"2020","journal-title":"Pharmacol Res"},{"key":"R54-20240830","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.canlet.2014.02.008","article-title":"Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming","volume":"356","author":"Cerella","year":"2015","journal-title":"Cancer Lett"},{"key":"R55-20240830","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.4103\/1673-5374.135328","article-title":"Quercetin alleviates high glucose-induced Schwann cell damage by autophagy","volume":"9","author":"Qu","year":"2014","journal-title":"Neural Regen Res"},{"key":"R56-20240830","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.jnutbio.2014.05.013","article-title":"Quercetin attenuates renal ischemia\/reperfusion injury via an activation of AMP-activated protein kinase-regulated autophagy pathway","volume":"25","author":"Chen","year":"2014","journal-title":"J Nutr Biochem"},{"key":"R57-20240830","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/s00210-018-1521-5","article-title":"Mitigation of cisplatin-induced peripheral neuropathy by canagliflozin in rats","volume":"391","author":"Abdelsameea","year":"2018","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"R58-20240830","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.3390\/app10144786","article-title":"Ginkgo biloba Alleviates Cisplatin-Mediated Neurotoxicity in Rats via Modulating APP\/Ab\/P2X7R\/P2Y12R and XIAP\/BDNF-Dependent Caspase-3 Apoptotic Pathway","volume":"10","author":"Gomaa","year":"2020","journal-title":"Appl Sci"},{"key":"R59-20240830","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.5301\/ijao.5000064","article-title":"Growth-promoting effects of quercetin on peripheral nerves in rats","volume":"34","author":"Wang","year":"2011","journal-title":"Int J Artif Organs"},{"key":"R60-20240830","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3389\/fnmol.2017.00285","article-title":"Quercetin declines apoptosis, ameliorates mitochondrial function and improves retinal ganglion cell survival and function in in vivo model of glaucoma in rat and retinal ganglion cell culture In vitro","volume":"10","author":"Gao","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"R61-20240830","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41392-018-0018-5","article-title":"The independence of and associations among apoptosis, autophagy, and necrosis","volume":"3","author":"Chen","year":"2018","journal-title":"Signal Transduct Target Ther"}],"container-title":["Journal of Microscopy and Ultrastructure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jmau.jmau_78_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:06:00Z","timestamp":1787760360000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jmau.jmau_78_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,5]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/jmau.jmau_78_22","relation":{},"ISSN":["2213-879X","2213-8803"],"issn-type":[{"value":"2213-879X","type":"print"},{"value":"2213-8803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,5]]},"assertion":[{"value":"2022-08-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-29","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}