{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:31:12Z","timestamp":1787758272125,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The biological nature of salivary gland neoplasms and the overlapping characteristics that result from the heterogeneity of the cells of origin make diagnosis difficult. Hence, we intend to present a case of low grade mucoepidermoid carcinoma (MEC) on the palate and to understand the importance of biomarker such as p63 in the early diagnosis of tumor as it also has a role in its histogenesis. A 53-year-old female reported with a unilateral swelling for 3 months on posterolateral palatal region of the right side. Clinical differentials for such palatal swellings include a varied spectrum of lesions such as reactive, benign, and malignant lesions. Based on the incisional and excisional biopsy, histopathological findings and immunohistochemical examination with p63 the case were diagnosed with low grade MEC. The tumor cell differentiation in MEC could be the result of multiplicity of differentiation pathways leading to the formation of various histological patterns. This case report highlights the complexity of salivary gland pathology diagnosis and role of specific tumor marker such as p63 as an early marker for differentiation of salivary gland tumor such as low grade MEC from other cystic lesions occurring on the palate.<\/jats:p>","DOI":"10.4103\/jmau.jmau_85_21","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T08:01:08Z","timestamp":1659513668000},"page":"104-107","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Role of p63 in Determining the Histogenesis of Low-Grade Neoplasms versus Cystic Lesion"],"prefix":"10.4103","volume":"12","author":[{"given":"Dipanshu","family":"Aggarwal","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology, ITS Centre for Dental Studies and Research, Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shefali","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, ITS Centre for Dental Studies and Research, Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshi","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, ITS Centre for Dental Studies and Research, Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devi Charan","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, ITS Centre for Dental Studies and Research, Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"R1-20240830","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.3390\/cancers13153910","article-title":"An overview on the histogenesis and morphogenesis of salivary gland neoplasms and evolving diagnostic approaches","volume":"13","author":"Iyer","year":"2021","journal-title":"Cancers (Basel)"},{"key":"R2-20240830","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1177\/10454411930040050201","article-title":"Current status of histogenetic and morphogenetic concepts of salivary gland tumorigenesis","volume":"4","author":"Dardick","year":"1993","journal-title":"Crit Rev Oral Biol Med"},{"key":"R3-20240830","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1002\/1097-0142(19920415)69:8<2021::AID-CNCR2820690803>3.0.CO;2-7","article-title":"Mucoepidermoid carcinoma of intraoral salivary glands. Evaluation and application of grading criteria in 143 cases","volume":"69","author":"Auclair","year":"1992","journal-title":"Cancer"},{"key":"R4-20240830","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1002\/(SICI)1097-0142(19980401)82:7<1217::AID-CNCR2>3.0.CO;2-C","article-title":"Mucoepidermoid carcinoma of the major salivary glands:Clinical and histopathologic analysis of 234 cases with evaluation of grading criteria","volume":"82","author":"Goode","year":"1998","journal-title":"Cancer"},{"key":"R5-20240830","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1097\/PAS.0000000000001252","article-title":"Mucoepidermoid carcinoma:A comparison of histologic grading systems and relationship to MAML2 rearrangement and prognosis","volume":"43","author":"Cipriani","year":"2019","journal-title":"Am J Surg Pathol"},{"key":"R6-20240830","doi-asserted-by":"crossref","first-page":"bcr2017221521","DOI":"10.1136\/bcr-2017-221521","article-title":"Mucoepidermoid carcinoma of the posterior-lateral border of tongue:A rare presentation","volume":"2017","author":"Mathew","year":"2017","journal-title":"BMJ Case Rep"},{"key":"R8-20240830","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.oooo.2012.09.005","article-title":"P63 expression in papillary cystadenoma and mucoepidermoid carcinoma of minor salivary glands","volume":"115","author":"Fonseca","year":"2013","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"R9-20240830","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/002215540305100201","article-title":"P63 is expressed in basal and myoepithelial cells of human normal and tumor salivary gland tissues","volume":"51","author":"Bilal","year":"2003","journal-title":"J Histochem Cytochem"},{"key":"R10-20240830","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.tripleo.2003.09.010","article-title":"Assessment of p63 expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and basal cell and canalicular adenomas","volume":"97","author":"Edwards","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"}],"container-title":["Journal of Microscopy and Ultrastructure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jmau.jmau_85_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:07:59Z","timestamp":1787756879000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jmau.jmau_85_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,4]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jmau.jmau_85_21","relation":{},"ISSN":["2213-879X","2213-8803"],"issn-type":[{"value":"2213-879X","type":"print"},{"value":"2213-8803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,4]]},"assertion":[{"value":"2021-10-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-30","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}