{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:23:16Z","timestamp":1787847796547,"version":"build-2784847793"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4]]},"abstract":"\n Background:<\/jats:title>\n Statins are among the first line of pharmacological treatment of lipid disorders and lowering serum cholesterol, but they have many side effects.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n The study aim was to evaluate the role of raisins in protecting the thyroid function and structure in a rat model of hypercholesterolemia, through biochemical and histopathological investigation.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Thirty male rats were randomly divided into three groups (\n n<\/jats:italic>\n = 10 each) of albino rats included the control, high cholesterol diet (HCD)-fed for 13 weeks and HCD plus Raisins were included in this study. Blood levels of glucose, insulin, cholesterol, lipids, thyroid-stimulating hormone (TSH), T3, T4, oxidants\/anti-oxidants were assessed. Thyroid gland was processed and examined histopathologically using light and electron microscopy.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Feeding HCD resulted in hypercholesterolemia in rats after 13 weeks as evidence by lipid profile. Ingestion of raisins along with HCD resulted in a significant (\n P<\/jats:italic>\n < 0.001) decrease in the levels of insulin, blood glucose, thyroxine (T4) and malondialdehyde (MDA), while the levels of TSH, T3 and total anti-oxidant capacity significantly (\n P<\/jats:italic>\n < 0.001) elevated. Raisins histologically alleviated the HCD-induced structural changes in the thyroid glands that included degenerated mitochondria and increased lipid droplets in the cytoplasm.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Simultaneous administration of raisins along with HCD, administrated for a short time, could modulate the negative effect on thyroid gland structure and function.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jmau.jmau_93_20","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T09:35:02Z","timestamp":1611826502000},"page":"55-62","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Raisins Preserve Thyroid Gland Function and Structure in an Animal Model of 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