{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:43:15Z","timestamp":1787071395914,"version":"build-2736575974"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>A large number of high-grade serous ovarian carcinomas originate in the fallopian tubes. Neoadjuvant chemotherapy followed by surgery may lead to a number of chemotherapy-induced changes in the ovary, which may lead to an erroneous diagnosis. We present a rare case of a 55-year-old postmenopausal woman who was clinically diagnosed with carcinoma of the right ovary; on histopathologic evaluation after neoadjuvant chemotherapy, the primary site was found to be the right fallopian tube. The right ovary showed chemotherapy-related changes along with extensive Leydig cell hyperplasia. As the presence of Leydig cell hyperplasia in this setting is an unusual finding, it may pose a diagnostic dilemma for the pathologist; so an awareness of this entity is important to avoid misdiagnosis.<\/jats:p>","DOI":"10.4103\/jmh.jmh_117_22","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T05:51:09Z","timestamp":1674798669000},"page":"247-250","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Leydig Cell Hyperplasia of Ovary \u2013 An Unusual Finding in Postneoadjuvant Chemotherapy Case of Primary Fallopian Tube Carcinoma"],"prefix":"10.4103","volume":"13","author":[{"given":"Kriti","family":"Chaturvedi","sequence":"first","affiliation":[{"name":"Department of Pathology and Lab Medicine, AIIMS, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Lab Medicine, AIIMS, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souvik","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Pathology and Lab Medicine, AIIMS, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeewan Ram","family":"Vishnoi","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, AIIMS, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aasma","family":"Nalwa","sequence":"additional","affiliation":[{"name":"Department of Pathology and Lab Medicine, AIIMS, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,1,14]]},"reference":[{"key":"R1-20250922","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3889\/oamjms.2017.044","article-title":"Primary fallopian tube carcinoma: A case report and literature review","volume":"5","author":"Rexhepi","year":"2017","journal-title":"Open Access Maced J Med Sci"},{"key":"R2-20250922","doi-asserted-by":"crossref","first-page":"433.","DOI":"10.3390\/cancers10110433","article-title":"Cell origins of high-grade serous ovarian cancer","volume":"10","author":"Kim","year":"2018","journal-title":"Cancers (Basel)"},{"key":"R4-20250922","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1593\/tlo.12265","article-title":"Histologic parameters predictive of disease outcome in women with advanced stage ovarian carcinoma treated with neoadjuvant chemotherapy","volume":"5","author":"Samrao","year":"2012","journal-title":"Transl Oncol"},{"key":"R5-20250922","first-page":"197871.","article-title":"Postchemotherapy histopathological evaluation of ovarian carcinoma: A 40-case study","volume":"2015","author":"Tiwana","year":"2015","journal-title":"Chemother Res Pract"},{"key":"R6-20250922","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.humpath.2018.10.022","article-title":"Quantification of Leydig cells and stromal hyperplasia in the postmenopausal ovary of women with endometrial carcinoma","volume":"85","author":"Reijnen","year":"2019","journal-title":"Hum Pathol"},{"key":"R7-20250922","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1136\/jcp.55.1.27","article-title":"Morphological effects of chemotherapy on ovarian carcinoma","volume":"55","author":"McCluggage","year":"2002","journal-title":"J Clin Pathol"}],"container-title":["Journal of Mid-life Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jmh.jmh_117_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:45:31Z","timestamp":1787067931000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jmh.jmh_117_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jmh.jmh_117_22","relation":{},"ISSN":["0976-7800","0976-7819"],"issn-type":[{"value":"0976-7800","type":"print"},{"value":"0976-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"2022-06-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}