{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:35:26Z","timestamp":1787070926606,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Osseous metaplasia of nonteratomous ovarian cyst is extremely rare, with 33 cases having been reported in the literature till 2020. Research is needed to fully understand the pathogenesis and clinical implications of this condition. Hence, we report this case of a 43-year-old woman with left-sided ovarian endometrioma and osseous metaplasia of both ovaries. A 43-year-old primipara presented with heavy menstrual bleeding and dysmenorrhea of 4 years duration. An ultrasound performed 5 months back showed bilateral ovarian endometriomas, and she had been treated medically. Upon presentation to us, an ultrasound revealed an adenomyotic uterus, with right ovary measuring 3.3 cm \u00d7 3.8 cm and left ovary measuring 2.5 cm \u00d7 2.8 cm. She was started on tablet dienogest once a day. A repeat ultrasound 3 months later revealed enlarged and calcified right ovary measuring 6 cm \u00d7 5 cm and left ovary measuring 5 cm \u00d7 4 cm. Her cancer antigen 125 was 21.8 U\/mL She denied for an MRI pelvis. Total abdominal hysterectomy and bilateral adnexectomy were performed. Histopathology of the right ovary showed ovarian parenchyma along with areas of extensive osseous metaplasia with calcifications. Sections from the left ovary showed ovarian parenchyma with an endometriotic cyst and moderate to dense inflammation with multiple foci of osseous metaplasia with calcifications. To conclude, osseous metaplasia of the ovary is rare. Our case was associated with benign ovarian endometrioma. The exact etiology of osseous metaplasia of the ovary is not known. We report this case to shed more light on the subject.<\/jats:p>","DOI":"10.4103\/jmh.jmh_145_25","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T13:00:55Z","timestamp":1757077255000},"page":"324-327","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Bilateral Osseous Metaplasia of the Ovary in Association with Endometrioma: A Rare Case Report"],"prefix":"10.4103","volume":"16","author":[{"given":"Sweta","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanhu Charan","family":"Dash","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shravan Kumar","family":"Bommanagoudar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarojini","family":"Raman","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"R1-20250908","first-page":"334","article-title":"Osseous metaplasia in a benign ovarian cyst in association with cloacal anomaly","volume":"58","author":"Godbole","year":"2005","journal-title":"J Clin Pathol"},{"key":"R2-20250908","first-page":"2356","article-title":"Non-teratomatous ossification of the ovary, a rare entity:Case report and review of the literature","volume":"13","author":"Yu","year":"2020","journal-title":"Int J Clin Exp Pathol"},{"key":"R3-20250908","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/PGP.0000000000000732","article-title":"Osseous metaplasia in low-grade ovarian serous carcinoma with a BRAF mutation:A case report","volume":"40","author":"Catteau","year":"2021","journal-title":"Int J Gynecol Pathol"},{"key":"R4-20250908","first-page":"531242","article-title":"Bilateral serous psammocarcinoma of ovary:Rare variant low grade serous carcinoma","volume":"2015","author":"Jena","year":"2015","journal-title":"Case Rep Obstet Gynecol"},{"key":"R5-20250908","first-page":"582","article-title":"Osseous metaplasia in ovarian tumours:A case with serous cystadenoma","volume":"60","author":"Miliaras","year":"2007","journal-title":"J Clin Pathol"},{"key":"R6-20250908","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1177\/1066896918766239","article-title":"An unusual case of extensive osseous metaplasia in fibroma of ovary","volume":"26","author":"Kumar","year":"2018","journal-title":"Int J Surg Pathol"},{"key":"R7-20250908","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4103\/0377-4929.48925","article-title":"Ossifying luteinized thecoma of the ovary with endometrial adenocarcinoma","volume":"52","author":"Pervatikar","year":"2009","journal-title":"Indian J Pathol Microbiol"},{"key":"R8-20250908","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/1535370219828694","article-title":"Bone morphogenetic protein signaling in inflammation","volume":"244","author":"Wu","year":"2019","journal-title":"Exp Biol Med (Maywood)"},{"key":"R9-20250908","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.4103\/2141-9248.121209","article-title":"Endometrial osseous metaplasia:Case report with literature review","volume":"3","author":"Patil","year":"2013","journal-title":"Ann Med Health Sci Res"},{"key":"R10-20250908","first-page":"241","article-title":"Simultaneous ovarian and endometrial osseous metaplasia:A case report","volume":"52","author":"Campo","year":"2007","journal-title":"J Reprod Med"}],"container-title":["Journal of Mid-life Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jmh.jmh_145_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:39:01Z","timestamp":1787067541000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jmh.jmh_145_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jmh.jmh_145_25","relation":{},"ISSN":["0976-7800","0976-7819"],"issn-type":[{"value":"0976-7800","type":"print"},{"value":"0976-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-06-16","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}