{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:33:00Z","timestamp":1787761980791,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Xanthogranulomatous inflammation, a specific form of chronic inflammation, is marked by parenchymal destruction, proliferative fibrosis, and infiltration of typical foamy histiocytes admixed with hemosiderin-laden macrophages and foreign-body giant cells. Myometrial xanthomatosis, a term designated for nodular or diffuse histiocytic hyperplasia of the myometrium, has been reported in association with pregnancy-related procedures. Moreover, a 2\u20133-fold increase in histiocytic counts has been observed in leiomyomatous areas than in adjacent normal myometrium. The first evidence of collections of lipid-laden macrophages was documented in the form of yellowish degeneration of uterine leiomyomas. We report a case of xanthogranulomatous change in a leiomyoma in a 47-year-old female who presented with abnormal uterine bleeding. To the best of our knowledge, this is the first report of xanthogranulomatous variant\/degenerative change in a leiomyoma. This case highlights a new variant of leiomyoma which both gynecologists and pathologists should be aware of as it may pose a diagnostic challenge both clinically as well as pathologically.<\/jats:p>","DOI":"10.4103\/jmh.jmh_158_22","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T09:01:23Z","timestamp":1688720483000},"page":"60-62","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Xanthogranulomatous Change in a Leiomyoma: First Report of an Extremely Rare Variant\/Degenerative Change"],"prefix":"10.4103","volume":"14","author":[{"given":"Mukta","family":"Pujani","sequence":"first","affiliation":[{"name":"Department of Pathology, ESIC Medical College and Hospital, NIT, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanika","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology, ESIC Medical College and Hospital, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Pathology, ESIC Medical College and Hospital, NIT, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Khandelwal","sequence":"additional","affiliation":[{"name":"Department of Pathology, ESIC Medical College, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raina","family":"Chawla","sequence":"additional","affiliation":[{"name":"Department of Obs and Gynae, ESIC Medical College and Hospital, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Obs and Gynae, ESIC Medical College and Hospital, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,7]]},"reference":[{"key":"R1-20240906","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-2559.1988.tb02078.x","article-title":"Xanthogranulomatous inflammation of the female genital tract","volume":"13","author":"Ladefoged","year":"1988","journal-title":"Histopathology"},{"key":"R2-20240906","doi-asserted-by":"crossref","first-page":"329","DOI":"10.12659\/AJCR.889248","article-title":"Histiocytic endometritis","volume":"14","author":"Wader","year":"2013","journal-title":"Am J Case Rep"},{"key":"R3-20240906","first-page":"28","article-title":"Xanthogranulomatous inflammation in gynecology:A rare and perplexing clinical entity","volume":"2","author":"Vats","year":"2019","journal-title":"Arch Obstet Gynecol Reprod 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Health"},{"key":"R7-20240906","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.4103\/2141-9248.121222","article-title":"Xanthogranulomatous endometritis:An unusual pathological entity mimicking endometrial carcinoma","volume":"3","author":"Makkar","year":"2013","journal-title":"Ann Med Health Sci Res"},{"key":"R8-20240906","first-page":"221","article-title":"Yellowish degeneration of uterine leiomyomas:Light microscopic and ultrastructural observations","volume":"29","author":"Lim","year":"1995","journal-title":"Korean J Pathol"}],"container-title":["Journal of Mid-life Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jmh.jmh_158_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:10:38Z","timestamp":1787760638000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jmh.jmh_158_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/jmh.jmh_158_22","relation":{},"ISSN":["0976-7800","0976-7819"],"issn-type":[{"value":"0976-7800","type":"print"},{"value":"0976-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2022-08-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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