{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T09:10:42Z","timestamp":1783933842128,"version":"3.55.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Adenoid cystic carcinoma (AdCC) of the breast is a rare malignancy (~0.1%), affecting women in their 50s\u201360s. It presents as a palpable mass with tubular, cribriform, and solid patterns and shows biphasic differentiation. C-Kit expression supports diagnosis. Despite its triple-negative status, AdCC has a favorable prognosis, except in solid-basaloid variants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This retrospective study was conducted in the Department of Histopathology, Apollo Cancer Center, Chennai, and included all cases of primary breast AdCC diagnosed between January 2014 and December 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twelve female patients were included, with a mean age of 55.5 years. All presented with a breast lump; right and left sides were equally involved, with the upper outer quadrant being the most common site (70%). Surgical management included wide local excision (WLE) (45.45%), modified radical mastectomy (36.36%), total mastectomy (9.09%), and chemotherapy\/immunotherapy in one patient (9.09%). Multifocality was seen in 16.66% (2\/12). Mean tumor size was 2.66 cm, and pT2 stage was most frequent (57.14%). One case showed local recurrence post-WLE; another developed lung metastasis. Histologically, 75% showed all three patterns with solid areas ranging from 10% to 90%. Perineural invasion was seen in 58.33% (7\/12) and lymphovascular invasion in 16.66% (2\/12). Most tumors were Nottingham Grade 2 (83.33%). All were progesterone receptor and HER2\/neu negative; estrogen receptor positivity was seen in two cases. C-Kit was positive in all tested cases. Ki-67 index ranged from 6% to 80%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Breast AdCC shows favorable prognosis. Most cases were pT2, stage IIA, with rare recurrence or metastasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jmh.jmh_200_25","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T08:00:29Z","timestamp":1783497629000},"page":"241-247","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Beyond its Rarity: A 10-year Study on Primary Adenoid Cystic Carcinoma of the Breast from a Tertiary Care Center"],"prefix":"10.4103","volume":"17","author":[{"given":"Pavithra","family":"Ethirajan","sequence":"first","affiliation":[{"name":"DNB Resident, Department of Pathology, Apollo Cancer Centre, Teynampet, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swetha Lakshmi","family":"Narla","sequence":"additional","affiliation":[{"name":"Senior Consultant, Department of Pathology, Apollo Cancer Centre, Teynampet, Chennai, Tamil Nadu, 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