{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:50:04Z","timestamp":1787071804477,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Abnormal uterine bleeding (AUB) is a common gynecological condition where there is an altered expression of estrogen receptors (ERs) and progesterone receptors (PRs) in the endometrium which may have a role in the etiology of abnormal bleeding.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n The objective of the study was to study the histopathological findings of endometrium and expression of estrogen and PRs in the endometrium in patients with AUB.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n All endometrial tissue from curettage and hysterectomy specimens of patients presenting to our Institution with complaints of AUB were included from November 2019 to November 2020 (prospective) and November 2015 to October 2019 (retrospective). This comprised a study population of 380 patients in the reproductive age group. The samples were evaluated for the spectrum of endometrial histopathological changes. Fifty-eight cases of endometrial hyperplasia and seven cases of endometrial adenocarcinoma were selected for immunohistochemical testing of ER and PR expression status. The IHC-stained slides were assessed for positive staining and intensity. The intensity of nuclear staining of ER and PR was graded in the epithelium and the stroma. H scores were calculated taking both the intensity and percentage of stained cells into account. The results were statistically analyzed by SPSS version 20,\n P<\/jats:italic>\n < 0.05 was considered significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n AUB was more prevalent among age group 41\u201350 years. The predominant pattern observed was secretory and proliferative endometrium. Of the 58 nonatypical hyperplasia, 51 patients showed positive nuclear staining with moderate-to-high intensity of ER and PR in both epithelium and stroma. Among seven endometrial adenocarcinomas, five cases were Grade I, one case was Grade II, and one case was of a serous papillary adenocarcinoma. Of the five Grade I adenocarcinomas, 3 out of 5 had absent and the rest showed mild-to-moderate ER expression; while 2 out of 5 had absent and the rest showed moderate-to-high PR expression. Grade II adenocarcinoma showed negative ER and PR expression. Serous papillary-type carcinoma also showed negative expression.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Endometrial carcinoma showed reduced hormonal expression compared to endometrial hyperplasia.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jmh.jmh_33_25","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T19:01:57Z","timestamp":1765220517000},"page":"395-401","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Spectrum of Histopathological Changes in Abnormal Uterine Bleeding with Estrogen and Progesterone Receptor Expression in Endometrial Hyperplasia and Carcinoma"],"prefix":"10.4103","volume":"16","author":[{"given":"Reeta","family":"Mohan","sequence":"first","affiliation":[{"name":"Department of Pathology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India"},{"name":"Department of Pathology, Pondicherry Institute of Medical Sciences, Pondicherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Mohanraj","sequence":"additional","affiliation":[{"name":"Department of Pathology, Pondicherry Institute of Medical Sciences, Pondicherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Ramdas","sequence":"additional","affiliation":[{"name":"Department of Pathology, Pondicherry Institute of Medical Sciences, Pondicherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaganandam","family":"Padma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Pondicherry Institute of Medical Sciences, Pondicherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"R1-20251212","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.14260\/Jemds\/2017\/327","article-title":"A study of dysfunctional uterine bleeding-clinical factors and endometrial histology","volume":"6","author":"Seena","year":"2017","journal-title":"J Evol Med Dent Sci"},{"key":"R2-20251212","doi-asserted-by":"crossref","first-page":"106199","DOI":"10.1016\/j.jsbmb.2022.106199","article-title":"Regulation of progesterone receptor expression in endometriosis, endometrial cancer, and breast cancer by estrogen, polymorphisms, transcription factors, epigenetic alterations, and ubiquitin-proteasome system","volume":"227","author":"Pu","year":"2023","journal-title":"J Steroid Biochem Mol Biol"},{"key":"R3-20251212","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.5455\/ijmsph.2017.0511619052017","article-title":"Evaluation of endometrial histopathological patterns in abnormal uterine bleeding:A study of 1545 cases","volume":"6","author":"Chhatrasal","year":"2017","journal-title":"Int J Med Sci Public Health"},{"key":"R4-20251212","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.18203\/2320-6012.ijrms20151184","article-title":"A study of expression of estrogen and progesterone receptor, in atrophic, hyperplastic and malignant endometrial lesions, with emphasis on relationship with prognostic parameters","volume":"3","author":"Kumari","year":"2015","journal-title":"Int J Res Med Sci"},{"key":"R5-20251212","doi-asserted-by":"crossref","first-page":"e0232231","DOI":"10.1371\/journal.pone.0232231","article-title":"Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia:A systematic review and meta-analysis","volume":"15","author":"Doherty","year":"2020","journal-title":"PLoS One"},{"key":"R6-20251212","doi-asserted-by":"crossref","first-page":"824","DOI":"10.18203\/2320-1770.ijrcog20170442","article-title":"Study of endometrial histopathology in women with abnormal uterine bleeding","volume":"6","author":"Gopalan","year":"2017","journal-title":"Int J Reprod Contracept Obstet Gynecol"},{"key":"R7-20251212","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.bpobgyn.2020.05.003","article-title":"Progesterone and endometrial cancer","volume":"69","author":"Gompel","year":"2020","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"R8-20251212","first-page":"2","article-title":"Management of Endometrial Hyperplasia","volume":"67","author":"Gallos","year":"2016","journal-title":"RCOG\/BSGE Green-Top Guideline. 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