{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:43:30Z","timestamp":1787071410171,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"\n Epithelioid leiomyosarcoma of the uterus is a rare soft-tissue tumor of the pelvis with <1% cases. It can be asymptomatic or can reach an enormous size, resulting in chronic pelvic pain, postmenopausal bleeding, or may cause bowel and bladder dysfunction. The diagnostic dilemma arises especially when they have epithelioid morphology. This case is being presented because of its rare incidence along with the diagnostic dilemma it presented due to epithelioid morphology which is a very rare presentation, especially challenging on small biopsies. This case also highlights the usefulness of immunohistochemical markers, such as WT1, p53, and p16, which has important diagnostic as well as prognostic values in rare variants of usual tumors. Leiomyosarcoma\n per se<\/jats:italic>\n is a highly aggressive tumor, therefore, timely diagnosis and management are advised.\n <\/jats:p>","DOI":"10.4103\/jmh.jmh_36_22","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T05:51:09Z","timestamp":1674798669000},"page":"241-243","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Epithelioid Leiomyosarcoma of the Uterus and the Diagnostic Challenge in Diagnosing it on Small Biopsy"],"prefix":"10.4103","volume":"13","author":[{"given":"Durre","family":"Aden","sequence":"first","affiliation":[{"name":"Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufian","family":"Zaheer","sequence":"additional","affiliation":[{"name":"Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Ranga","sequence":"additional","affiliation":[{"name":"Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,1,14]]},"reference":[{"key":"R1-20250922","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00404-002-0309-4","article-title":"Breast metastasis from uterine leiomyosarcoma: A case report","volume":"267","author":"Lin","year":"2003","journal-title":"Arch Gynecol Obstet"},{"key":"R3-20250922","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/PAS.0000000000001795","article-title":"Epithelioid leiomyosarcoma of the uterus: Modern outcome-based appraisal of diagnostic criteria in a large institutional series","volume":"46","author":"Chapel","year":"2022","journal-title":"Am J Surg Pathol"},{"key":"R4-20250922","doi-asserted-by":"crossref","first-page":"bcr1120115144","DOI":"10.1136\/bcr.11.2011.5144","article-title":"Epithelioid leiomyosarcoma of uterus","volume":"2012","author":"Setia","year":"2012","journal-title":"BMJ Case Rep"},{"key":"R5-20250922","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/00006254-197904000-00017","article-title":"Leiomyosarcoma of the uterus: Case reports and a review","volume":"34","author":"Gallup","year":"1979","journal-title":"Obstet Gynecol Surv"},{"key":"R6-20250922","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1365-2559.2009.03231.x","article-title":"Uterine sarcomas in Norway. A histopathological and prognostic survey of a total population from 1970 to 2000 including 419 patients","volume":"54","author":"Abeler","year":"2009","journal-title":"Histopathology"},{"key":"R7-20250922","doi-asserted-by":"crossref","DOI":"10.1002\/9781118655344.ch15","article-title":"Uterine leiomyosarcoma","author":"del Carmen","year":"2014","journal-title":"Uncommon Gynecologic Cancers"},{"key":"R8-20250922","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/j.ejca.2007.04.008","article-title":"Upregulation of Wilms\u2019 tumour gene 1 (WT1) in uterine sarcomas","volume":"43","author":"Coosemans","year":"2007","journal-title":"Eur J Cancer"},{"key":"R9-20250922","doi-asserted-by":"crossref","first-page":"E2126.","DOI":"10.3390\/cancers12082126","article-title":"Genomic database analysis of uterine leiomyosarcoma mutational profile","volume":"12","author":"Astolfi","year":"2020","journal-title":"Cancers (Basel)"}],"container-title":["Journal of Mid-life Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jmh.jmh_36_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:45:44Z","timestamp":1787067944000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jmh.jmh_36_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jmh.jmh_36_22","relation":{},"ISSN":["0976-7800","0976-7819"],"issn-type":[{"value":"0976-7800","type":"print"},{"value":"0976-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"2022-02-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}