{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:59:26Z","timestamp":1787169566578,"version":"build-2736575974"},"reference-count":4,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Gestational trophoblastic neoplasia is of uncommon occurrence in postmenopausal women, unlike in the reproductive age group. The diagnosis is based on levels of beta-human chorionic gonadotropin (hCG) in serum. The management is similar to that in premenopausal women. First case, fifty-two-year-old, P8 L4A3 postmenopausal female, presented with postmenopausal bleeding. Diagnosis of choriocarcinoma was made in view of raised serum betah-CG levels with uterine lesion with lung metastasis. The patient started on Multi-agent chemotherapy. The patient succumbed to death due to Grade III hematological toxicity while on the first cycle of the EMA\/CO regimen. Second case, forty-two-year-old, P2 L2, postmenopausal, with a history of Choriocarcinoma 20 years, back presented with postmenopausal bleeding. After metastatic workup, the patient started on EMACO regimen. She is asymptomatic and on regular follow-up after 8 cycles of chemotherapy. Third case, forty-seven-year-old, P4 L4, postmenopausal, presented with histopathology report suggestive of choriocarcinoma after hysterectomy. After evaluation, lung metastasis was detected. The patient responded to eight cycles to Multi-agent chemotherapy and is on regular follow-up. Choriocarcinoma is a rare gynecological malignancy in postmenopausal women. High index of suspicion is required for its diagnosis. The prognosis of the disease is not encouraging as compared to the premenopausal woman<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jmh.jmh_38_21","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T09:26:24Z","timestamp":1642670784000},"page":"319-322","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Choriocarcinoma in Post-Menopausal Women- 3 Case Reports with Review of Literature"],"prefix":"10.4103","volume":"12","author":[{"given":"Upasana","family":"Baruah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roma","family":"Jethani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debabrata","family":"Barmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimpy","family":"Begum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haelom","family":"Liegise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megha","family":"Nandwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-14-20240906","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.gore.2017.09.016","article-title":"Primary choriocarcinoma in postmenopausal women: Two case reports and review of the Texas Cancer Registry","volume":"22","author":"Rafanan","year":"2017","journal-title":"Gynecologic oncology reports"},{"key":"R2-14-20240906","doi-asserted-by":"crossref","first-page":"i39","DOI":"10.1093\/annonc\/mdt345","article-title":"Gestational trophoblastic disease: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"24","author":"Seckl","year":"2013","journal-title":"Ann Oncol"},{"key":"R3-14-20240906","first-page":"79","article-title":"A rare case of postmenopausal bleeding: Choriocarcinoma","volume":"1","author":"Evsen","year":"2012","journal-title":"J Clin Gynecol Obstet"},{"key":"R4-14-20240906","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/GME.0000000000000968","article-title":"Postmenopausal choriocarcinoma: A rare case report and review of the literature","volume":"25","author":"Guo","year":"2018","journal-title":"Menopause"}],"container-title":["Journal of Mid-life Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jmh.jmh_38_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:07:21Z","timestamp":1787166441000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jmh.jmh_38_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":4,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/jmh.jmh_38_21","relation":{},"ISSN":["0976-7800"],"issn-type":[{"value":"0976-7800","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]}}}