{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:30:59Z","timestamp":1787070659888,"version":"build-2736575974"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Atherosclerosis is the most common cause of ischemic cardiovascular disease (CVD). However, approximately 20%\u201340% of cases of acute myocardial infarction (AMI) in patients aged &lt;50 years can be attributed to genetic factors, and coronavirus disease 2019 (COVID-19) is a risk factor for blood clots and AMI. We aimed to describe the clinical, angiographic, and developmental characteristics and COVID-19 severity and vaccination status in patients aged \u226445 years with AMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively analyzed 2624 patients with AMI by reviewing the results of coronary angiography and percutaneous coronary intervention and medical reports. The study included patients aged &gt;18 years who met the universal definition of AMI but excluded those with missing medical records or coronary angiograms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In total, 2624 patients with AMI (aged 18\u201385 years) were included in the study and divided into two groups based on age: \u226445 (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1286) and &gt;45 years (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1338). Total cholesterol and triglyceride levels were significantly higher in patients aged \u226445 years (5.6 \u00b1 2.1 and 3.2 \u00b1 2.1 mmol\/L, respectively,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.007) than in those aged &gt;45 years (6.3 \u00b1 1.8 and 3.1 \u00b1 2.0 mmol\/L, respectively,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Overall, 1745 and 879 patients were unvaccinated and fully vaccinated, respectively; severe and critical COVID-19 infections were more common among unvaccinated patients in both age groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Younger patients with AMI were more likely to be smokers with no hypertension, diabetes mellitus, or previous AMI. In contrast, they were more likely to have hypercholesterolemia and hypertriglyceridemia, single-vessel disease, Type C lesions, and a history of drug-eluting stent use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jmh.jmh_59_24","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T10:07:47Z","timestamp":1729159667000},"page":"173-181","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Influence of Clinical, Angiographic, and Developmental Characteristics and COVID-19 Severity and Vaccination Status on Young Patients with Acute Myocardial Infarction"],"prefix":"10.4103","volume":"15","author":[{"given":"Yethindra","family":"Vityala","sequence":"first","affiliation":[{"name":"Honorary International Faculty, AJ Institute of Medical Sciences and Research Centre, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Palagudi","sequence":"additional","affiliation":[{"name":"Department of General Medicine, P. 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Institute of Medical Sciences and Research, Kuppam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneha","family":"Para","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Maheshwara Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna Chaitanya","family":"Meduri","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Maheshwara Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Praneeth","family":"Duvvuri","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Maheshwara Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi Narasimha Sandeep","family":"Manne","sequence":"additional","affiliation":[{"name":"Department of General Medicine, 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