{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:19:38Z","timestamp":1787771978142,"version":"build-2784847793"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Breast cancer is the most common cancer in women worldwide, with an estimated 2.26 million new cases diagnosed in 2020. The important genes associated include BRCA1, BRCA2, CHEK2, PTEN, TP53, and ataxia\u2013telangiectasia mutated (ATM). ATM is responsible for repairing double-strand breaks in DNA making it a significant candidate in breast cancer predisposition. ATM variant, c.1066-6T&gt;G, has been associated with an increased risk of breast cancer in some but not all studies. The Indian studies on the allele IVS10-6T&gt;G are very limited. The present study was undertaken to evaluate the associations between c.1066-6T&gt;G ATM gene variant and breast cancer incidence in Indian women and its correlation with histological grade, stage, and surrogate molecular classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Routine histopathological processing was done after adequate fixation of the specimen followed by staining with hematoxylin and eosin and immunohistochemistry for ER, PR, Her2neu, and Ki67. Single-nucleotide polymorphism for ATM allele IVS10-6T&gt;G was studied after DNA extraction, polymerase chain reaction amplification, and restriction enzyme digestion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All cases were found to be negative for ATM allele IVS10-6T&gt;G mutation. Maximum number of patients (19 cases; 52.78%) had pT2 stage tumor followed by 11 patients (30.56%) with pT3. Majority of cases were luminal B (11; 30.56%) followed by triple negative (10; 27.78%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although the results obtained by mutational analysis in the present study are not in agreement with the previous study on Indian women it agrees with the numerous previous studies and meta-analyses done on women with breast carcinoma in the Western world.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jmh.jmh_71_23","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T10:01:03Z","timestamp":1708682463000},"page":"272-279","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Ataxia\u2013Telangiectasia Mutated IVS10 Mutation in Breast Cancer Along with Clinicopathological Parameters"],"prefix":"10.4103","volume":"14","author":[{"given":"Sana","family":"Ahuja","sequence":"first","affiliation":[{"name":"Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himani","family":"Aneja","sequence":"additional","affiliation":[{"name":"Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit Kumar","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Ranga","sequence":"additional","affiliation":[{"name":"Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, 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