{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:35:22Z","timestamp":1787070922735,"version":"build-2736575974"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Orthostatic hypotension (OH) refers to a clinically significant quick drop in blood pressure upon standing. This is due to hypovolemia, autonomic dysfunction, or adverse drug effects. Venlafaxine is a serotonin-norepinephrine reuptake inhibitor which has been typically associated with hypertension. However, several cases of OH have been reported predominantly in elderly people at higher doses. This case highlights a unique presentation of symptoms at the therauptic dose that too in a patient without conventional risk factors. A 55-year-old postmenopausal female with bipolar disorder presented with generalized weakness, dizziness, and lightheadedness a week after initiating venlafaxine for depressive symptoms. Clinical evaluation revealed significant hypotension with normal systemic, neurological, and cardiological examinations. Laboratory investigations didn\u2019t reveal anything either. The temporal association between the initiation of venlafaxine and symptom onset led to discontinuation of the drug coupled with supportive management. Symptoms resolved within 48 h, with blood pressure returning to baseline as well. Thus, this case highlights the need for clinicians to be vigilant about potential OH even at standard doses of venlafaxine in patients without typical risk factors. Hence, proving that early identification of such symptoms and prompt dose adjustment\/change in therapy can mitigate complications and optimize patient outcomes.<\/jats:p>","DOI":"10.4103\/jmh.jmh_81_25","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T13:00:32Z","timestamp":1757077232000},"page":"318-320","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Unmasking Venlafaxine-induced Orthostatic Hypotension in a Postmenopausal Woman: A Case Report on an Uncommon Adverse Effect"],"prefix":"10.4103","volume":"16","author":[{"given":"Prabhat Kumar","family":"Agrawal","sequence":"first","affiliation":[{"name":"Department of Medicine, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandipta Kumar","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchika","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhant","family":"Dev","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"R1-20250908","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10286-011-0119-5","article-title":"Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome","volume":"21","author":"Freeman","year":"2011","journal-title":"Clin Auton Res"},{"key":"R2-20250908","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1186\/s12888-024-05875-0","article-title":"Prevalence and associated factors of depression in postmenopausal women:A systematic review and meta-analysis","volume":"24","author":"Li","year":"2024","journal-title":"BMC Psychiatry"},{"key":"R3-20250908","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0893-133X(01)00298-6","article-title":"Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors","volume":"25","author":"Bymaster","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"R5-20250908","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2165\/11591710-000000000-00000","article-title":"Antipsychotic pharmacotherapy and orthostatic hypotension:Identification and management","volume":"25","author":"Gugger","year":"2011","journal-title":"CNS Drugs"},{"key":"R6-20250908","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.jash.2018.06.002","article-title":"The association between antidepressant use and orthostatic hypotension in older people:A matched cohort study","volume":"12","author":"Briggs","year":"2018","journal-title":"J Am Soc Hypertens"},{"key":"R7-20250908","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1592\/phco.23.15.1668.31951","article-title":"Fatality related to a 30-g venlafaxine overdose","volume":"23","author":"Mazur","year":"2003","journal-title":"Pharmacotherapy"},{"key":"R8-20250908","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"Amethod for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo","year":"1981","journal-title":"Clin Pharmacol Ther"}],"container-title":["Journal of Mid-life Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jmh.jmh_81_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:38:58Z","timestamp":1787067538000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jmh.jmh_81_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jmh.jmh_81_25","relation":{},"ISSN":["0976-7800","0976-7819"],"issn-type":[{"value":"0976-7800","type":"print"},{"value":"0976-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-04-09","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}