{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:58:57Z","timestamp":1790330337701,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"Abstract<\/jats:title>\n \n Introduction:<\/jats:title>\n Postmastectomy radiotherapy plays a pivotal role in improving locoregional control and survival outcomes in early as well as in advanced-stage breast cancer patients. With the transition from conventional radiotherapy techniques to advanced intensity-modulated approaches, evaluation based solely on physical dose parameters is no longer sufficient. Radiobiological modelling provides a more clinically meaningful framework by quantifying tumor control and normal tissue complications.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n The objective of this prospective study was to evaluate the radiobiological differences between three radiotherapy planning techniques, namely three-dimensional conformal radiotherapy (3DCRT), field-in-field forward planned intensity modulated radiotherapy (FIF-FP-IMRT), and inversely planned intensity modulated radiotherapy (IP-IMRT) in postmastectomy breast cancer patients.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n The present prospective study involved 150 postmastectomy breast cancer patients who have undergone chemotherapy treatment. Each patient was planned with three radiotherapy planning techniques, namely 3DCRT, FIF-FP-IMRT, and IP-IMRT for comparative radiobiological analysis. Radiobiological parameters, namely tumor control probability (TCP) and normal tissue complication probability (NTCP), were then calculated and compared for the three planning techniques.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The mean TCP values were comparable among all three techniques, with no statistically significant difference. However, significant differences were observed in most of the NTCP parameters (\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The present study demonstrates that advanced radiotherapy planning techniques provide significant radiobiological advantages over conventional techniques in postmastectomy breast cancer patients. Among the three evaluated techniques, IP-IMRT showed the most favorable radiobiological profile, followed by FIF-FP-IMRT, while 3DCRT showed comparatively higher NTCP.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jmp.jmp_106_26","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:01:55Z","timestamp":1790168515000},"page":"646-652","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Radiobiological Evaluation of Radiotherapy Techniques Using Equivalent Uniform Dose, Tumor Control Probability, and Normal Tissue Complication Probability in Postmastectomy Breast Cancer"],"prefix":"10.4103","volume":"51","author":[{"given":"Garima","family":"Gaur","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Guru Gobind Singh Medical College and Hospital, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Guru Gobind Singh Medical College and Hospital, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baltej","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Community and Medicine, Guru Gobind Singh Medical College, Faridkot, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pardeep","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Guru Gobind Singh Medical College and Hospital, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod Kumar","family":"Dangwal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Government Medical College, Patiala, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja Paramjeet Singh","family":"Banipal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Government Medical College, Patiala, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"R1-20260925","author":"Supe","year":"1993","journal-title":"Application of Linear Quadratic Model of Dose Effect Relationship to Radiotherapy [PhD Thesis]. 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