{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:27:53Z","timestamp":1786649273532,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"\n Purpose:<\/jats:title>\n The purpose of the study was to evaluate longitudinal changes in health-related quality of life (HRQoL) among patients undergoing radiotherapy for solid tumors, using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) questionnaire and to identify symptom and function trajectories over time in relation to clinical and demographic parameters.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n In this prospective observational study, 211 adult patients with histologically confirmed solid malignancies (excluding breast cancer) were enrolled at a tertiary oncology center. HRQoL was assessed at four time points: Baseline (T1), end of radiotherapy (T2), 1-month post-treatment (T3), and 6 months\u2019 post-treatment (T4), using the validated EORTC QLQ-C30 tool. Statistical analysis included repeated measures analysis of variance and Bonferroni-adjusted\n post hoc<\/jats:italic>\n tests.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Global health status improved significantly from T1 (67.0) to T4 (76.0) (\n P<\/jats:italic>\n < 0.001). Functional domains, physical, emotional, cognitive, and social functioning, also showed significant improvement (all\n P<\/jats:italic>\n < 0.001), whereas role functioning improved modestly (\n P<\/jats:italic>\n = 0.009). Symptom scores such as fatigue, pain, nausea\/vomiting, and insomnia declined significantly (\n P<\/jats:italic>\n < 0.001), whereas dyspnea showed no significant change (\n P<\/jats:italic>\n = 0.573). Financial difficulties decreased over time (\n P<\/jats:italic>\n < 0.001). Subgroup analyses revealed sex-based variations in symptom burden, with females reporting higher pain and financial strain early post-treatment, and males experiencing greater appetite loss and delayed economic burden.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n This study represents preliminary 6-month follow-up data; ongoing surveillance will provide insights into late toxicity and long-term survivorship. Persistent symptoms such as dyspnea highlight the need for targeted supportive interventions. Longitudinal HRQoL monitoring can guide personalized care and survivorship planning.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jmp.jmp_134_25","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T20:00:48Z","timestamp":1767211248000},"page":"725-730","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal Trends in Health-related Quality of Life among Radiotherapy Patients: A Short-term Result of Prospective EORTC QLQ- C30-based Study"],"prefix":"10.4103","volume":"50","author":[{"given":"Ainain Yousuf","family":"Baba","sequence":"first","affiliation":[{"name":"Department of Physics, University of Kashmir, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abid","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology, Sher I Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obair Yousuf","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Acharya Shri Chander College of Medical Sciences and Hospital, Jammu, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misbah","family":"Shahid","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Acharya Shri Chander College of Medical Sciences and Hospital, Jammu, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","DOI":"10.1007\/s11764-024-01708-x","article-title":"Quality of life, healthcare usage and finances of UK cancer survivors five years post-diagnosis: A matched controlled 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