{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:58:53Z","timestamp":1790330333041,"version":"4.1.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose\/Aim:<\/jats:title>\n                    <jats:p>The aim of the study was to assess the impact of tumor size on dose-volume histograms (DVHs) and clinical outcomes in patients with early-stage non-small cell lung cancer (NSCLC) undergoing stereotactic body radiation therapy (SBRT) using the CyberKnife M6 System with a lung-optimized treatment module.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Retrospective analysis was performed on 12 patients diagnosed with NSCLC receiving SBRT treatment. Analysis of cumulative DVHs was done to evaluate dose distribution in the planning target volume (PTV) and surrounding organs at risk. The patient population was divided according to tumor size; one group was patients with PTV &lt;12 cc and the other group was patients with PTV &gt;12 cc. Statistical analysis was performed using SPSS software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All treatment plans achieved adequate target coverage with sharp dose gradients. There was slight improvement in terms of dose distribution and response rate for smaller tumors (PTV &lt;12 cc); however, these differences did not show statistical significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>There were no statistically significant differences between tumor volume and DVH parameters or clinical response in SBRT treatment of NSCLC. Most of the patients received biological effective dose (\u03b1\/\u03b2 =10) values above 100 Gy, with some of them receiving &gt;120 Gy, which has been associated with improved treatment outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jmp.jmp_161_26","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:01:29Z","timestamp":1790168489000},"page":"713-718","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Is there Any Impact of Tumor Volume in Stereotactic Body Radiation Therapy for Lung Cancer? A Cohort for T1, 2 Non-small Cell Lung Cancer Cases"],"prefix":"10.4103","volume":"51","author":[{"given":"Maria T.","family":"Dimitropoulou","sequence":"first","affiliation":[{"name":"Department of Applied Medical Physics, National and Kapodistrian University of Athens, Medical School, ATTIKON University Hospital, Chaidari, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalliopi","family":"Platoni","sequence":"additional","affiliation":[{"name":"Department of Applied Medical Physics, National and Kapodistrian University of Athens, Medical School, ATTIKON University Hospital, Chaidari, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftheria","family":"Alevronta","sequence":"additional","affiliation":[{"name":"Department of Applied Medical Physics, National and Kapodistrian University of Athens, Medical School, ATTIKON University Hospital, Chaidari, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis","family":"Kouloulias","sequence":"additional","affiliation":[{"name":"Department of Applied Medical Physics, National and Kapodistrian University of Athens, Medical School, ATTIKON University Hospital, Chaidari, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Armpilia","sequence":"additional","affiliation":[{"name":"First Radiology Department, National and Kapodistrian University of Athens, Medical School, ARETAIEION University Hospital, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zygogianni","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiation Oncology, National and Kapodistrian University of Athens, Medical School, ATTIKON University Hospital, Chaidari, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"R1-20260925","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/cncr.31196","article-title":"Surgery versus stereotactic body radiation therapy for stage I non-small cell lung cancer: A comprehensive review","volume":"124","author":"Tandberg","year":"2018","journal-title":"Cancer"},{"key":"R4-20260925","journal-title":"International Commission on Radiation Units and Measurements. Prescribing, Recording, and Reporting Photon Beam Therapy. International Commission on Radiation Units and Measurements; 1993. ICRU Report 50"},{"issue":"3 Suppl","key":"R6-20260925","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1016\/j.ijrobp.2009.06.091","article-title":"Radiation dose-volume effects in the lung","volume":"76","author":"Marks","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R7-20260925","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.ijrobp.2012.04.043","article-title":"Predicting radiation pneumonitis after chemoradiation therapy for lung cancer: an international individual patient data meta-analysis","volume":"85","author":"Palma","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R8-20260925","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s13014-019-1334-9","article-title":"Lung Stereotactic Body Radiation Therapy (SBRT) dose gradient and PTV volume: a retrospective multi-center analysis","volume":"14","author":"Hoffman","year":"2019","journal-title":"Radiat Oncol"},{"key":"R9-20260925","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1111\/1759-7714.14203","article-title":"Impact of tumor size and location on lung dose difference between stereotactic body radiation therapy techniques for non-small cell lung cancer","volume":"12","author":"Jang","year":"2021","journal-title":"Thorac Cancer"},{"key":"R10-20260925","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1002\/mp.12804","article-title":"Evaluation of target coverage and margins adequacy during CyberKnife Lung Optimized Treatment","volume":"45","author":"Ricotti","year":"2018","journal-title":"Med Phys"},{"key":"R12-20260925","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/COC.0000000000000162","article-title":"Stage I lung SBRT clinical practice patterns","volume":"40","author":"Corso","year":"2017","journal-title":"Am J Clin Oncol"},{"key":"R13-20260925","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s12094-023-03345-9","article-title":"Biologically effective dose (BED) value lower than 120 Gy improve outcomes in lung SBRT","volume":"26","author":"Jimenez-Jimenez","year":"2024","journal-title":"Clin Transl Oncol"}],"container-title":["Journal of Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jmp.jmp_161_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:00:56Z","timestamp":1790326856000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jmp.jmp_161_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jmp.jmp_161_26","relation":{},"ISSN":["0971-6203","1998-3913"],"issn-type":[{"value":"0971-6203","type":"print"},{"value":"1998-3913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-06-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}