{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:19:14Z","timestamp":1787750354733,"version":"build-2784847793"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"\n Purpose:<\/jats:title>\n This research compares the dosimetric characteristics of sequential boost (SB) and simultaneous integrated boost (SIB) techniques using intensity-modulated delivery techniques for breast radiotherapy in left-sided breast cancer patients following breast-conserving surgery (BCS).<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Twenty-seven left-sided breast cancer patients who underwent BCS were retrospectively analyzed. Two treatment plans per patient were generated using Eclipse Treatment Planning System. SB delivered 40 Gy\/15 fractions (four-arc volumetric modulated arc therapy [VMAT]) to whole breast, then 12.5 Gy\/5 fractions (six-field intensity-modulated radiotherapy [IMRT]) to tumor bed, totaling 52.5 Gy\/20 fractions. SIB delivered 40 Gy to whole breast and 48 Gy to tumor bed simultaneously in 15 fractions through four-arc VMAT. Target coverage, dose homogeneity, conformity, and organ-at-risk doses were compared using paired\n t<\/jats:italic>\n -tests (\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Both techniques achieved adequate target coverage with comparable whole breast mean doses. SB demonstrated significantly superior V95% coverage (98.4% vs. 95.7%), while SIB significantly achieved superior dose homogeneity within the integrated plan (HI: 0.31 \u00b1 0.025 vs. 0.14 \u00b1 0.032). SIB showed 31% reduction in total monitor units (10669 \u00b1 881 vs. 15450 \u00b1 1374 MU,\n P<\/jats:italic>\n < 0.001) and 25% shorter treatment duration. SIB achieved superior left anterior descending artery sparing (mean: 5.70 \u00b1 1.78 vs. 6.54 \u00b1 2.64 Gy,\n P<\/jats:italic>\n = 0.003) and spinal cord protection (maximum: 15.3 \u00b1 1.55 vs. 18.7 \u00b1 4.51 Gy,\n P<\/jats:italic>\n < 0.001). SB provided better ipsilateral lung sparing (mean: 11.8 \u00b1 1.44 vs. 12.4 \u00b1 1.04 Gy,\n P<\/jats:italic>\n < 0.001). Both achieved mean heart doses <5 Gy.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Both techniques achieved adequate target coverage, SIB offers superior treatment efficiency and coronary artery sparing, while SB provides better V95% coverage and lung sparing. Technique selection should be individualized based on patient factors and institutional priorities.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jmp.jmp_16_26","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T20:01:43Z","timestamp":1782244903000},"page":"376-386","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Dosimetric Comparison of Sequential Boost versus Simultaneous Integrated Boost Intensity-modulated Delivery Techniques in Left-sided Breast Cancer Radiotherapy: A Planning Study"],"prefix":"10.4103","volume":"51","author":[{"given":"Mukesh Kumar","family":"Zope","sequence":"first","affiliation":[{"name":"Department of Medical Physics, State Cancer Institute, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepali","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, State Cancer Institute, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Physics, Amity Institute of Applied Sciences, Amity University, Noida, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Goswami","sequence":"additional","affiliation":[{"name":"Deparment of Chemical Biological Radiological and Nuclear Defence, Institute of Nuclear Medicine and Allied Sciences Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, State Cancer Institute, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, 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