{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:09:32Z","timestamp":1789132172757,"version":"build-2803163510"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effectiveness of knowledge-based planning (KBP) with additional multi-criteria optimization (MCO) for the volumetric modulated arc therapy (VMAT) of the larynx.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Twenty previously treated VMAT was used to train the KBP model. A manual plan (MP) was created using 10 patients. The KBP was generated by a single optimization with no planner intervention during the optimization. An additional MCO was applied to KBP (KBP + MCO) to further improve the plan\u2019s quality. All plans were normalized to the planning target volume (PTV) D\n                      <jats:sub>50%<\/jats:sub>\n                      (percentage of the volume receiving 50% of the prescribed dose). The PTV D95%, conformity index (CI), doses to the carotid artery (V\n                      <jats:sub>10-50 Gy<\/jats:sub>\n                      : absolute volume receiving 10\u201350 Gy), and maximum dose to the spinal cord were calculated for the three planning methods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The average PTV D\n                      <jats:sub>95%<\/jats:sub>\n                      for MP, KBP, and KBP + MCO were 90.2%, 92.8%, and 94.1%, respectively. The average CI95% for KBP + MCO was 0.06 and 0.02 higher than that for MP and KBP, respectively. PTV and CI\n                      <jats:sub>95%<\/jats:sub>\n                      were not significantly different between the three planning methods (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). KBP + MCO showed that the carotid artery for V10-30 Gy with MP was smaller than that for KBP, and there were no significant differences between V\n                      <jats:sub>40 Gy<\/jats:sub>\n                      and V\n                      <jats:sub>50 Gy<\/jats:sub>\n                      . The maximum dose to the spinal cord did not differ significantly among the three planning methods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>KBP + MCO could improve dose sparing of the carotid artery while maintaining PTV coverage in laryngeal VMAT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jmp.jmp_192_24","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:01:30Z","timestamp":1751515290000},"page":"227-232","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Knowledge-Based Planning and Multi-criteria Optimization Combination with Volumetric Modulated Arc Therapy for Patients with Laryngeal Cancer"],"prefix":"10.4103","volume":"50","author":[{"given":"Hideharu","family":"Miura","sequence":"first","affiliation":[{"name":"Hiroshima High-precision Radiotherapy Cancer Center, Hiroshima, Japan"},{"name":"Department of Radiation Oncology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Hiroshima High-precision Radiotherapy Cancer Center, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Kenjo","sequence":"additional","affiliation":[{"name":"Hiroshima High-precision Radiotherapy Cancer Center, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Nakao","sequence":"additional","affiliation":[{"name":"Hiroshima High-precision Radiotherapy Cancer Center, Hiroshima, Japan"},{"name":"Department of Radiation Oncology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Hiroshima High-precision Radiotherapy Cancer Center, Hiroshima, Japan"},{"name":"Department of Radiation Oncology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Kagemoto","sequence":"additional","affiliation":[{"name":"Hiroshima High-precision Radiotherapy Cancer Center, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"R1-20250703","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.ijrobp.2005.05.018","article-title":"Radical radiotherapy for early glottic cancer: Results in a series of 1087 patients from two Italian radiation oncology centers. 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