{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:37:57Z","timestamp":1786649877746,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The present study aimed to compare the dosimetric parameters for a fractional re-imaging approach using computed tomographic (CT) scans before the first and third fractions with hybrid brachytherapy for carcinoma cervix patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Patients with cervical carcinoma who received radical chemoradiation and hybrid brachytherapy were prospectively included for the analysis. The first fraction was delivered on day 1 after applicator insertion and the second and third fractions were delivered on day 2, 6 h apart. Two plans were created for each patient using CT-based planning, one before the first fraction (Plan 1) and the other before the third fraction (Plan 2). The dose prescribed was 7 Gy per fraction to high-risk clinical target volume (HRCTV). The dosimetric parameters compared between the two plans were D90 HRCTV, D98 IRCTV, TRAK, D0.1cc, and D2cc to the bladder, rectum, sigmoid, and dose to the ICRU 89 radiation therapy (RV) point, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fifteen patients were included for the analysis. The mean HRCTV volume was 31 cc. The mean D90 HRCTV was 87.86 Gy EQD2 for Plan 1 versus 84.64 Gy EQD2 for Plan 2, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.018). On analysis, there was a significant difference between the mean D0.1cc rectum between Plan 1 and Plan 2 (89.57 Gy vs. 115.27 Gy) and the D2cc of the rectum between Plan 1 and Plan 2 (70.9 Gy vs. 77.2 Gy). The bladder, sigmoid, and RV ICRU 89 point dose between the two plans were not significantly different.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In carcinoma cervix patients undergoing hybrid brachytherapy in a single application multiple fraction approach, there can be significant variations in rectum doses. These results indicate that fractional re-imaging is necessary to optimize the plan and spare organ-at-risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jmp.jmp_227_25","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T20:00:46Z","timestamp":1767211246000},"page":"693-697","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Intrafraction Variation of Dose-volume Parameters in Hybrid Brachytherapy for Carcinoma Cervix"],"prefix":"10.4103","volume":"50","author":[{"given":"Devender Reddy","family":"Boja","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India"},{"name":"Department of Physics, University College of Science, Osmania University, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harjot Kaur","family":"Bajwa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, American Oncology of Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. V. N. Madhusudhana","family":"Sresty","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deleepkumar","family":"Gudipudi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohith","family":"Singareddy","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hima Bindu","family":"Pitta","sequence":"additional","affiliation":[{"name":"Department of Physics, University College of Science, Osmania University, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.3892\/ol.2020.11754","article-title":"Cervical cancer in low and middle-income countries","volume":"20","author":"Hull","year":"2020","journal-title":"Oncol Lett"},{"key":"R2-20260420","doi-asserted-by":"crossref","first-page":"e206","DOI":"10.1016\/S1470-2045(14)70481-4","article-title":"Present status of human papillomavirus vaccine development and implementation","volume":"16","author":"Herrero","year":"2015","journal-title":"Lancet Oncol"},{"key":"R3-20260420","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int J Cancer"},{"key":"R4-20260420","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12939-018-0768-2","article-title":"Disparities in cervical screening participation: A comparison of Russian, Somali and Kurdish immigrants with the general Finnish population","volume":"17","author":"Idehen","year":"2018","journal-title":"Int J Equity Health"},{"key":"R5-20260420","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.gore.2017.12.005","article-title":"Evidence-based improvisation: Facing the challenges of cervical cancer care in Uganda","volume":"24","author":"Swanson","year":"2018","journal-title":"Gynecol Oncol Rep"},{"key":"R6-20260420","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S1470-2045(20)30753-1","article-title":"MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): A multicentre prospective cohort study","volume":"22","author":"P\u00f6tter","year":"2021","journal-title":"Lancet Oncol"},{"key":"R7-20260420","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.radonc.2004.12.015","article-title":"Recommendations from gynaecological (GYN) GEC-ESTRO working group (I): Concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV","volume":"74","author":"Haie-Meder","year":"2005","journal-title":"Radiother Oncol"},{"key":"R8-20260420","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1136\/ijgc-2021-003056","article-title":"Image-guided brachytherapy in cervical cancer including fractionation","volume":"32","author":"Sturdza","year":"2022","journal-title":"Int J Gynecol Cancer"},{"key":"R9-20260420","first-page":"123","article-title":"Brachytherapy: A critical component of primary radiation therapy forcervical cancer, Holschneider","volume":"18","author":"Christine","year":"2019","journal-title":"From the Society of Gynecologic Oncology (SGO) and the American Brachytherapy Society (ABS). 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