{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:05:13Z","timestamp":1787169913137,"version":"build-2736575974"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The focus of this work was given on the relative stopping power (RSP) using the water equivalent thickness (WET) validation on tissue substitutes and real pig organs, as well as a dosimetric comparison of proton treatment plans between single-energy computed tomography (SECT) and dual-energy computed tomography (DECT)-based dose calculations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The CT calibration curve of SECT and DECT data was generated using the stoichiometric calibration method. WET measurement was performed for RSP validation using a Giraffe dosimeter (IBA dosimetry) in various substitute tissues (Gammex) and real pig tissues. The thorax (008A, CIRS) and head (731-HN, CIRS) phantoms were used to generate proton plans. The dosimetric evaluations of SECT and DECT-based plans were performed using the gamma analysis with 1%\/1 mm and the dose\u2013volume histograms (DVHs) comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>For RSP validation of substitute tissues, the largest percent WET difference between measurement and calculation was observed up to 17.9% (4 mm) in lung tissue, using SECT based. In real pig tissues, the average WET difference was 2.3% \u00b1 2.1% and 2.5% \u00b1 2.3% for SECT and DECT, respectively. The average gamma passed of about 92.1% for the lung and 96.8% for the head regions was reported. For the lung region, the DVH of the target dose was observed with a higher predicted dose in SECT than in DECT, while results in the head region were in good agreement for both SECT and DECT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The performed dosimetric comparison indicates the dose differences between SECT and DECT. The impact of the CT calibration curve is more pronounced for the thorax region.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jmp.jmp_27_23","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T09:01:34Z","timestamp":1695200494000},"page":"292-297","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Dosimetric Comparison between Single-energy Computed Tomography and Dual-energy Computed Tomography Relative to Stopping Power Estimation in Proton Therapy"],"prefix":"10.4103","volume":"48","author":[{"given":"Thamonwan","family":"Chirdchid","sequence":"first","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirinya","family":"Ruangchan","sequence":"additional","affiliation":[{"name":"Her Royal Highness Princess Maha Chakri Sirindhorn Proton Center, Bangkok, Thailand"},{"name":"Department of Radiology, Division of Radiation Oncology, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taweap","family":"Sanghangthum","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"},{"name":"Her Royal Highness Princess Maha Chakri Sirindhorn Proton Center, Bangkok, Thailand"},{"name":"Department of Radiology, Division of Radiation Oncology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"R1-20240906","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1200\/JCO.2006.09.7816","article-title":"Particle radiation therapy using proton and heavier ion 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therapy","volume":"42","author":"Park","year":"2015","journal-title":"Med Phys"},{"key":"R13-20240906","doi-asserted-by":"crossref","first-page":"103","DOI":"10.21873\/invivo.12681","article-title":"Evaluation of stopping power ratio calculation using dual-energy computed tomography with fast kilovoltage switching for treatment planning of particle therapy","volume":"36","author":"Ohira","year":"2022","journal-title":"In Vivo"},{"key":"R14-20240906","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ijrobp.2016.10.022","article-title":"Clinical implementation of dual-energy CT for proton treatment planning on pseudo-monoenergetic CT scans","volume":"97","author":"Wohlfahrt","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Journal of Medical 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