{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:58:50Z","timestamp":1790330330199,"version":"4.1.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Magnetic spinel ferrite nanoparticles with redox-active surface characteristics have attracted increasing attention as candidate nanomaterials for enhancing radiation-mediated therapeutic response. This study involved the creation of CoFe\u2082O\u2084 nanoparticles through a precisely managed chemical co-precipitation approach, followed by thermal annealing to obtain structurally stable inverse spinel nanostructures. The formation of a phase-pure cubic spinel lattice was confirmed by X-ray diffraction and Raman spectroscopy, whereas electron microscopy revealed predominantly spherical nanoparticles with sizes in the range of 20\u201340 nm. Nitrogen adsorption\u2013desorption analysis demonstrated mesoporous surface characteristics with specific surface area values between 42 and 73 m\n                    <jats:sup>2<\/jats:sup>\n                    \/g, supporting enhanced nanoparticle\u2013cell interaction. The incorporation of redox-active Co\n                    <jats:sup>2<\/jats:sup>\n                    \u207a and Fe\n                    <jats:sup>3<\/jats:sup>\n                    \u207a species into the spinel lattice was validated by X-ray photoelectron spectroscopy. Biological assessments utilizing the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay indicated concentration-dependent cytotoxicity against MCF-7 breast cancer lines; however, normal L929 fibroblasts retained comparatively higher viability, suggesting targeted action. The observed cytotoxic behavior is attributed to reactive oxygen species-mediated mitochondrial dysfunction induced by transition-metal-dependent redox activity. In addition, antioxidant activity measured using 2,2 diphenyl-1-picrylhydrazyl assay confirmed concentration-dependent radical scavenging behavior, supporting the redox-modulating capability of the synthesized nanoparticles. The combined structural stability, mesoporous surface architecture, and ROS-mediated selective cytotoxic response suggest that CoFe\u2082O\u2084 nanoparticles may serve as promising ferrite-based candidate nanomaterials for nanoparticle-assisted radiotherapy applications. These findings support further investigation of mixed-metal ferrite nanoparticles as potential radiosensitizing agents under clinically relevant fractionated radiation dose conditions.\n                  <\/jats:p>","DOI":"10.4103\/jmp.jmp_83_26","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:02:10Z","timestamp":1790168530000},"page":"536-545","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["CoFe\u2082O\u2084 Nanoparticles: Synthesis, Physicochemical Characterization, and Reactive Oxygen Species-mediated Selective Cytotoxicity for Radiotherapy Applications"],"prefix":"10.4103","volume":"51","author":[{"given":"Ananda","family":"Jadhav","sequence":"first","affiliation":[{"name":"Department of Physics, Sanjay Ghodawat University Kolhapur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep B.","family":"Wategoankar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Kisan Veer Mahavidyalaya, Wai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishali R.","family":"Shinde","sequence":"additional","affiliation":[{"name":"Department of Physics, ADT\u2019s Shardabai Pawar Art\u2019s, Commerce and Science College, Shardanagar, Baramati, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarita","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Physics, Sanjay Ghodawat University Kolhapur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"R1-20260925","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jconrel.2021.05.042","article-title":"Magnetic nanoparticles for cancer theranostics: Advances and 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