{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:11:47Z","timestamp":1790208707454,"version":"4.1.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"\n Introduction:<\/jats:title>\n The purpose of the study was to calculate, tumor control probability (TCP) and normal tissue complication probability (NTCP) in cervical cancer patients and to clinically correlate the outcomes with a follow-up period of 24 months.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n One hundred and fifty patients were included in the present study who received 46 Gy\/23 fractions\/4\u00bd weeks of external beam radiotherapy with concurrent cisplatin chemotherapy, followed by intracavitary brachytherapy of 3 different fractionations regimens, i.e., 9.5 Gy per fraction of two fractions (50 patients in Arm1), 7.5 Gy per fraction of three fractions (50 patients in Arm2), and 6.0 Gy per fraction of four fractions (50 patients in Arm3).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The median TCP value for Arm1, Arm2, and Arm3 was 99.6%, 94%, and 98.1%, respectively, (\n P<\/jats:italic>\n < 0.01). The median NTC\n P<\/jats:italic>\n value for bladder in Arm1, Arm2, and Arm3 was 0.17%, 0.04%, and 0.07%, respectively, (\n P<\/jats:italic>\n = 0.05). The median NTC\n P<\/jats:italic>\n value for rectum in Arm1, Arm2, and Arm3 was 4.73%, 4.35%, and 3.17%, respectively, (\n P<\/jats:italic>\n = 0.052). The overall survival (OS) of 90%, 86%, and 84% was found for Arm1, Arm2, and Arm3, respectively, at 24 months of follow-up.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n TCP, NTCP, and OS rates were found higher in Arm1 as compared to the other two arms. The complications found in all arms were less, low grade, and manageable. Hence, Arm1, i.e., 9.5 Gy per fraction of two fractions can be concluded as the optimum fractionation regime in terms of radiobiological parameters as well as overall patient comfort.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jmp.jmp_86_24","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T04:00:43Z","timestamp":1727064043000},"page":"363-369","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Tumor Control and Normal Tissue Complications in High-dose-rate Brachytherapy for Cervical Cancer Patients Using Ir-192 Radioactive Source"],"prefix":"10.4103","volume":"49","author":[{"given":"Gurpreet","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pardeep","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod Kumar","family":"Dangwal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Government Medical College, Patiala, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baltej","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garima","family":"Gaur","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romikant","family":"Grover","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simrandeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachana","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Sociology, Guru Nanak Dev University, Amritsar, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9,21]]},"reference":[{"key":"R1-20260427","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1016\/S2214-109X(19)30482-6","article-title":"Estimates of incidence and mortality of cervical cancer in 2018: A worldwide analysis","volume":"8","author":"Arbyn","year":"2020","journal-title":"Lancet Glob Health"},{"key":"R2-20260427","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1200\/GO.20.00122","article-title":"Cancer statistics, 2020: Report from National Cancer Registry Programme, India","volume":"6","author":"Mathur","year":"2020","journal-title":"JCO Glob Oncol"},{"key":"R3-20260427","first-page":"295","article-title":"Cancer in Punjab: Evidence from cancer atlas","volume":"27","author":"Labani","year":"2015","journal-title":"J Community Health Res"},{"key":"R4-20260427","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.brachy.2011.07.003","article-title":"American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. 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