{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:27:56Z","timestamp":1787772476990,"version":"build-2784847793"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>A significant discrepancy between the results of previous studies is identified regarding the diagnostic efficacy of chest computed tomography (CT) for coronavirus disease 2019 (COVID-19). We aimed to evaluate the diagnostic efficacy of chest CT for COVID-19.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Suspected cases of COVID-19 with fever, cough, dyspnea, and evidence of pneumonia on chest CT scan were enrolled in the study. The accuracy, sensitivity, and specificity of chest CT were determined according to real-time reverse transcriptase-polymerase chain reaction (RT-PCR) results as the gold standard method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The study population comprised 356 suspected cases of COVID-19 (174 men and 182 women; age range 3\u201396 years; mean age \u00b1 standard deviation, 55.21 \u00b1 18.38 years). COVID-19 patients were diagnosed using chest CT with 89.8% sensitivity, 78.1% accuracy, 21.3% specificity, 84.7% positive predictive value, and 30.23% negative predictive value. The odds ratio was 2.39 (95% confidence interval, 1.16\u20134.91). Typical CT manifestations of COVID-19 were observed in 48 (13.5%) patients with negative RT-PCR results and 30 (8.4%) patients with confirmed positive RT-PCR results had no radiological manifestations. Kappa coefficient of chest CT for diagnosis of COVID-19 was 0.78.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The results show that when RT-PCR results are negative, chest CT could be considered as a complementary diagnostic method for the diagnosis of COVID-19 patients. A more comprehensive diagnostic method could be established by combining the chest CT examination, clinical symptoms, and RT-PCR assay.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jmss.jmss_118_21","type":"journal-article","created":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T17:57:25Z","timestamp":1717264645000},"page":"129-135","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Efficacy of Chest Computed Tomography for Coronavirus Disease 2019"],"prefix":"10.4103","volume":"13","author":[{"given":"Seyed Salman","family":"Zakariaee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Salmanipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Kaffashian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20240830","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N Engl J Med"},{"key":"R2-7-20240830","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2214\/AJR.20.22959","article-title":"Clinical features and chest CT manifestations of coronavirus disease 2019 (COVID-19) in a single-center study in Shanghai, China","volume":"215","author":"Cheng","year":"2020","journal-title":"AJR Am J Roentgenol"},{"key":"R3-7-20240830","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.2214\/AJR.20.22954","article-title":"Coronavirus disease 2019 (COVID-19): Role of chest CT in diagnosis and management","volume":"214","author":"Li","year":"2020","journal-title":"AJR Am J Roentgenol"},{"key":"R4-7-20240830","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1007\/s00330-020-06817-6","article-title":"CT image visual quantitative evaluation and clinical classification of coronavirus disease (COVID-19)","volume":"30","author":"Li","year":"2020","journal-title":"Eur Radiol"},{"key":"R5-7-20240830","doi-asserted-by":"crossref","first-page":"e200034","DOI":"10.1148\/ryct.2020200034","article-title":"Imaging profile of the COVID-19 infection: Radiologic findings and literature review","volume":"2","author":"Ng","year":"2020","journal-title":"Radiol Cardiothorac Imaging"},{"key":"R6-7-20240830","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1080\/14737159.2020.1757437","article-title":"Real-time RT-PCR in COVID-19 detection: Issues affecting the results","volume":"20","author":"Tahamtan","year":"2020","journal-title":"Expert Rev Mol Diagn"},{"key":"R7-7-20240830","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3389\/fmed.2020.00231","article-title":"Clinical features, diagnosis, and treatment of COVID-19 in hospitalized patients: A systematic review of case reports and case series","volume":"7","author":"Tahvildari","year":"2020","journal-title":"Front Med (Lausanne"},{"key":"R8-7-20240830","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/RLI.0000000000000674","article-title":"Clinical and high-resolution CT features of the COVID-19 infection: Comparison of the initial and follow-up changes","volume":"55","author":"Xiong","year":"2020","journal-title":"Invest Radiol"},{"key":"R9-7-20240830","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jrid.2020.04.003","article-title":"Clinical and imaging features of COVID-19","volume":"7","author":"Chen","year":"2020","journal-title":"Radiol Infect Dis"},{"key":"R10-7-20240830","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1148\/radiol.2462070712","article-title":"Fleischner Society: Glossary of terms for thoracic imaging","volume":"246","author":"Hansell","year":"2008","journal-title":"Radiology"},{"key":"R11-7-20240830","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1007\/s00330-020-06731-x","article-title":"Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): A study of 63 patients in Wuhan, China","volume":"30","author":"Pan","year":"2020","journal-title":"Eur Radiol"},{"key":"R12-7-20240830","doi-asserted-by":"crossref","first-page":"E115","DOI":"10.1148\/radiol.2020200432","article-title":"Sensitivity of chest CT for COVID-19: Comparison to RT-PCR","volume":"296","author":"Fang","year":"2020","journal-title":"Radiology"},{"key":"R13-7-20240830","doi-asserted-by":"crossref","first-page":"E41","DOI":"10.1148\/radiol.2020200343","article-title":"Chest CT for typical coronavirus disease 2019 (COVID-19) pneumonia: Relationship to negative RT-PCR testing","volume":"296","author":"Xie","year":"2020","journal-title":"Radiology"},{"key":"R14-7-20240830","doi-asserted-by":"crossref","first-page":"200463","DOI":"10.1148\/radiol.2020200463","article-title":"Chest CT findings in coronavirus disease-19 (COVID-19): Relationship to duration of infection","volume":"295","author":"Bernheim","year":"2020","journal-title":"Radiology"},{"key":"R15-7-20240830","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1148\/radiol.2020200370","article-title":"Time course of lung changes at chest CT during recovery from coronavirus disease 2019 (COVID-19)","volume":"295","author":"Pan","year":"2020","journal-title":"Radiology"},{"key":"R17-7-20240830","doi-asserted-by":"crossref","first-page":"E32","DOI":"10.1148\/radiol.2020200642","article-title":"Correlation of chest CT and RT-PCR testing for coronavirus disease 2019 (COVID-19) in China: A report of 1014 cases","volume":"296","author":"Ai","year":"2020","journal-title":"Radiology"},{"key":"R18-7-20240830","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3390\/v13071321","article-title":"Comparison and sensitivity evaluation of three different commercial real-time quantitative PCR kits for SARS-CoV-2 detection","volume":"13","author":"Banko","year":"2021","journal-title":"Viruses"},{"key":"R19-7-20240830","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.4269\/ajtmh.20-1484","article-title":"Clinical performance and analytical sensitivity of three SARS-CoV-2 nucleic acid diagnostic tests","volume":"104","author":"Freire-Paspuel","year":"2021","journal-title":"Am J Trop Med Hyg"},{"key":"R20-7-20240830","doi-asserted-by":"crossref","first-page":"e200152","DOI":"10.1148\/ryct.2020200152","article-title":"Radiological Society of North America Expert Consensus document on reporting chest CT findings related to COVID-19: Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA","volume":"2","author":"Simpson","year":"2020","journal-title":"Radiol Cardiothorac Imaging"},{"key":"R21-7-20240830","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1021\/acscentsci.0c00501","article-title":"Assay techniques and test development for COVID-19 diagnosis","volume":"6","author":"Carter","year":"2020","journal-title":"ACS Cent Sci"},{"key":"R22-7-20240830","doi-asserted-by":"crossref","first-page":"e0235844","DOI":"10.1371\/journal.pone.0235844","article-title":"CT in relation to RT-PCR in diagnosing COVID-19 in The Netherlands: A prospective study","volume":"15","author":"Gietema","year":"2020","journal-title":"PLoS One"},{"key":"R23-7-20240830","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.cca.2020.03.009","article-title":"Positive rate of RT-PCR detection of SARS-CoV-2 infection in 4880 cases from one hospital in Wuhan, China, from Jan to Feb 2020","volume":"505","author":"Liu","year":"2020","journal-title":"Clin Chim Acta"},{"key":"R24-7-20240830","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/jmv.25930","article-title":"Characteristics of patients with coronavirus disease (COVID-19) confirmed using an IgM-IgG antibody test","volume":"92","author":"Xie","year":"2020","journal-title":"J Med Virol"},{"key":"R25-7-20240830","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1016\/j.jinf.2020.03.005","article-title":"Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients","volume":"80","author":"Liu","year":"2020","journal-title":"J Infect"},{"key":"R26-7-20240830","first-page":"1","article-title":"Evaluating the accuracy of different respiratory specimens in the laboratory diagnosis and monitoring the viral shedding of 2019-nCoV infections","volume":"11","author":"Yang","year":"2020","journal-title":"medRxiv"}],"container-title":["Journal of Medical Signals &amp; Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jmss.jmss_118_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:48:47Z","timestamp":1787770127000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jmss.jmss_118_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/jmss.jmss_118_21","relation":{},"ISSN":["2228-7477"],"issn-type":[{"value":"2228-7477","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]}}}