{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:22:14Z","timestamp":1787772134548,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Orofacial clefts (OFCs), including cleft lip (CL), cleft palate (CP), and CL with palate (CL\/P), are relatively common congenital birth defects occurring in approximately 1 in 500 to 1 in 2500 live births. Detecting OFCs during prenatal ultrasound screening is crucial for informed decision-making and multidisciplinary medical care. This review provides a practical guide for routine and advanced screening for OFCs during mid-pregnancy. The Maarse classification system facilitates effective communication among the multidisciplinary team, categorizing OFCs into five types. Basic ultrasound views encompass coronal, sagittal, and axial imaging of the face and hard palate. Additional visualization techniques are employed in case of suspected anomalies during the initial screening. Advanced ultrasound views provided by the expert in prenatal OFC diagnosis include imaging of the posterior edge of the hard palate and the posterior part of the soft palate. Detected OFCs exhibit a range of severity and affect different structures, underscoring the importance of accurate detection and classification for appropriate treatment planning. Implementing a standardized screening protocol for OFCs is essential. By enhancing detection rates and enabling early diagnosis, prenatal ultrasound screening contributes to improved patient outcomes and facilitates timely intervention by the multidisciplinary team. In conclusion, this review emphasizes the significance of standardized protocols and specialized techniques for prenatal ultrasound screening of OFCs. Early detection and classification of these malformations play a vital role in comprehensive management, ensuring that affected individuals and their families receive the appropriate care and support they need.<\/jats:p>","DOI":"10.4103\/jmu.jmu_123_23","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T05:01:09Z","timestamp":1711083669000},"page":"8-13","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Prenatal Ultrasound Imaging of Orofacial Clefts: A Pictorial Essay"],"prefix":"10.4103","volume":"32","author":[{"given":"Tze-Yi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Fetal Medicine, Taiji Clinic, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung-Yao","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine, Taiji Clinic, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"R1-20240830","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/pd.4631","article-title":"A practical prenatal ultrasound classification system for common oral clefts","volume":"35","author":"Maarse","year":"2015","journal-title":"Prenat Diagn"},{"key":"R2-20240830","first-page":"2862","article-title":"A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13","volume":"25","author":"Leslie","year":"2016","journal-title":"Hum Mol Genet"},{"key":"R3-20240830","doi-asserted-by":"crossref","first-page":"35","DOI":"10.20517\/2347-9264.2020.99","article-title":"Equality in cleft and craniofacial care","volume":"7","author":"Sharratt","year":"2020","journal-title":"Plast Aesthetic Res"},{"key":"R4-20240830","doi-asserted-by":"crossref","first-page":"13916","DOI":"10.1038\/s41598-020-70906-1","article-title":"Multidisciplinary team approach to the prenatal management of orofacial clefts:A single center cohort study in Taiwan","volume":"10","author":"Ko","year":"2020","journal-title":"Sci Rep"},{"key":"R5-20240830","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/uog.984","article-title":"Two- and three-dimensional sonographic assessment of the fetal face. 1. 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