{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:49:25Z","timestamp":1787755765410,"version":"build-2784847793"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Ultrasound"],"published-print":{"date-parts":[[2019]]},"DOI":"10.4103\/jmu.jmu_44_19","type":"journal-article","created":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T09:59:04Z","timestamp":1561370344000},"page":"81","source":"Crossref","is-referenced-by-count":24,"title":["Safety of perfluorobutane (Sonazoid) in characterizing focal liver lesions"],"prefix":"10.4103","volume":"27","author":[{"given":"Yi-Hong","family":"Chou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ja-Der","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen-Yung","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Jer","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jui-Ting","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sien-Sing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien-Ying","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chui-Mei","family":"Tiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/0929-6441.261156-1","first-page":"187","volume-title":"Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver \u2013 Update 2012: A WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS","author":"Claudon","year":"2013","journal-title":"Ultrasound Med Biol"},{"key":"key-10.4103\/0929-6441.261156-2","first-page":"86","volume-title":"Efficacy of perflubutane microbubble-enhanced ultrasound in the characterization and detection of focal liver lesions: Phase 3 multicenter clinical trial","author":"Moriyasu","year":"2009","journal-title":"AJR Am J Roentgenol"},{"key":"key-10.4103\/0929-6441.261156-3","first-page":"807","volume-title":"Pathomorphological study of kupffer cells in hepatocellular carcinoma and hyperplastic nodular lesions in the liver","author":"Tanaka","year":"1996","journal-title":"Hepatology"},{"key":"key-10.4103\/0929-6441.261156-4","first-page":"152","volume-title":"Usefulness of sonazoid-ultrasonography during hepatectomy in patients with liver tumors: A preliminary study","author":"Nanashima","year":"2011","journal-title":"J Surg Oncol"},{"key":"key-10.4103\/0929-6441.261156-5","first-page":"824","volume-title":"Physicochemical characteristics of sonazoid, a new contrast agent for ultrasound imaging","author":"Sontum","year":"2008","journal-title":"Ultrasound Med Biol"},{"key":"key-10.4103\/0929-6441.261156-6","first-page":"49","volume-title":"Ultrasound contrast agents: Balancing safety versus efficacy","author":"Main","year":"2009","journal-title":"Expert Opin Drug Saf"},{"key":"key-10.4103\/0929-6441.261156-7","unstructured":"Medical Imaging Corporation. Available from: http:\/\/www.mic-tw.com\/product_detail.php?ID=17. [Last accessed on 2019 Mar 17]."},{"key":"key-10.4103\/0929-6441.261156-8","first-page":"643","volume-title":"Mechanism of hepatic parenchyma-specific contrast of microbubble-based contrast agent for ultrasonography: Microscopic studies in rat liver","author":"Watanabe","year":"2007","journal-title":"Invest Radiol"},{"key":"key-10.4103\/0929-6441.261156-9","unstructured":"ACR manual on contrast media. v. 10.2. Chapter 7: Allergic-like and physiologic reactions to intravascular iodinated contrast media. U.S.A.: American College of Radiology 2016; p. 22-28."},{"key":"key-10.4103\/0929-6441.261156-10","first-page":"217","volume-title":"Ultrasonic contrast agents: Safety considerations reviewed","author":"ter","year":"2002","journal-title":"Eur J Radiol"},{"key":"key-10.4103\/0929-6441.261156-11","first-page":"290","volume-title":"Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue","author":"Skyba","year":"1998","journal-title":"Circulation"},{"key":"key-10.4103\/0929-6441.261156-12","first-page":"578","volume-title":"Aretrospective comparison of mortality in critically ill hospitalized patients undergoing echocardiography with and without an ultrasound contrast agent","author":"Exuzides","year":"2010","journal-title":"JACC Cardiovasc Imaging"},{"key":"key-10.4103\/0929-6441.261156-13","first-page":"742","volume-title":"Meta-analysis of adverse cardiovascular events associated with echocardiographic contrast agents","author":"Khawaja","year":"2010","journal-title":"Am J Cardiol"},{"key":"key-10.4103\/0929-6441.261156-14","first-page":"83","volume-title":"Primum non nocere.Why can't we use second generation ultrasound contrast agents for the examination of children?","author":"Piskunowicz","year":"2011","journal-title":"Ultraschall Med"},{"key":"key-10.4103\/0929-6441.261156-15","first-page":"187","volume-title":"WFUMB safety symposium on echo-contrast agents: Nature and types of ultrasound contrast agents","author":"Bouakaz","year":"2007","journal-title":"Ultrasound Med Biol"},{"key":"key-10.4103\/0929-6441.261156-16","first-page":"368","volume-title":"Double-contrast ultrasound: A novel surveillance tool for hepatocellular carcinoma","author":"Kudo","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"key-10.4103\/0929-6441.261156-17","first-page":"1734","volume-title":"Computer-aided diagnosis for the classification of focal liver lesions by use of contrast-enhanced ultrasonography","author":"Shiraishi","year":"2008","journal-title":"Med Phys"},{"key":"key-10.4103\/0929-6441.261156-18","first-page":"790","volume-title":"Analysis of morphological vascular changes of hepatocellular carcinoma by microflow imaging using contrast-enhanced sonography","author":"Sugimoto","year":"2008","journal-title":"Hepatol Res"},{"key":"key-10.4103\/0929-6441.261156-19","first-page":"173","volume-title":"Recommendations on the safe use of ultrasound contrast agents","author":"Barnett","year":"2007","journal-title":"Ultrasound Med Biol"},{"key":"key-10.4103\/0929-6441.261156-20","first-page":"211","volume-title":"Low mechanical index contrast mode versus high mechanical index contrast mode: Which is a more sensitive method for detecting sonazoid microbubbles in the liver of normal subjects?","author":"Nihonmatsu","year":"2001","journal-title":"J Med Ultrason ("},{"key":"key-10.4103\/0929-6441.261156-21","first-page":"409","volume-title":"Improved imaging of liver metastases with stimulated acoustic emission in the late phase of enhancement with the US contrast agent SH U 508A: Early experience","author":"Blomley","year":"1999","journal-title":"Radiology"}],"container-title":["Journal of Medical Ultrasound"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T18:32:46Z","timestamp":1786732366000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/JMU.JMU_44_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019]]}},"alternative-id":["261156"],"URL":"https:\/\/doi.org\/10.4103\/jmu.jmu_44_19","relation":{},"ISSN":["0929-6441"],"issn-type":[{"value":"0929-6441","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]}}}