{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:29:10Z","timestamp":1786728550915,"version":"build-2736575974"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The damaging effect of rheumatoid arthritis (RA) on cartilage, bone, ligaments, and tendons has raised the importance of the disease activity and severity assessment to enable therapeutic decisions and to evaluate disease outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The aim is to compare the clinical examination of the Disease Activity Score (DAS)-28 with the musculoskeletal ultrasonography (US) examination in RA patients. Moreover, finding if we can use ultrasonographical results as a tool for predicting subsequent radiological damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>It is a longitudinal study included 60 adult RA patients. Patients were under assessment at baseline, 6 months, and 12 months from the recruitment time. Twenty-eight joints of DAS were assessed for tenderness and swelling. US gray scale (GS) and US power Doppler (PD) score also was done at each visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>DAS-28, with its parameters, is positively and highly significantly correlated to synovitis severity both by US GS and US-PD score along the study follow-up visits. There was highly significant difference between the number of 28 swollen and tender joints by clinical examination with both US GS and US-PD. Linear regression analysis to predict the number of swollen and tender joints after 12 months showed significance between US PD with swollen and tender joints\u2019 numbers. The correlation was positive and significant between Larsen score at 12 months with GS US and PD US assessment, but linear regression analysis was only significant for Larsen score with only GS US.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>GS US and PD is a sensitive and reliable noninvasive method complementary to standard clinical assessment and could be a tool for predicting subsequent joints\u2019 damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jmu.jmu_74_18","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T06:35:10Z","timestamp":1546929310000},"page":"33-39","source":"Crossref","is-referenced-by-count":2,"title":["A Longitudinal Study of the 28 Joints of Disease Activity Score by Ultrasonographical Examination in Rheumatoid Arthritis Patients"],"prefix":"10.4103","volume":"27","author":[{"given":"Rabab Hussin","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama Sayed","family":"Daifallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan Sayed M.","family":"Abozaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esam Mohmad. Abu","family":"Alfadl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar Abdel-Rahman","family":"Elsayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/0929-6441.249634-1","first-page":"2784","volume-title":"Measuring function in rheumatoid arthritis: Identifying reversible and irreversible components","author":"Aletaha","year":"2006","journal-title":"Arthritis Rheum"},{"key":"key-10.4103\/0929-6441.249634-2","first-page":"729","volume-title":"The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials.The committee on outcome measures in rheumatoid arthritis clinical trials","author":"Felson","year":"1993","journal-title":"Arthritis Rheum"},{"key":"key-10.4103\/0929-6441.249634-3","first-page":"7","volume-title":"Preliminary criteria for clinical remission in rheumatoid arthritis","author":"Pinals","year":"1982","journal-title":"Bull Rheum Dis"},{"key":"key-10.4103\/0929-6441.249634-4","first-page":"727","volume-title":"American college of rheumatology.Preliminary definition of improvement in rheumatoid arthritis","author":"Felson","year":"1995","journal-title":"Arthritis Rheum"},{"key":"key-10.4103\/0929-6441.249634-5","first-page":"S09","volume-title":"Assessment of disease activity and treatment outcomes in rheumatoid arthritis","author":"Farheen","year":"2011","journal-title":"J Manag Care Pharm"},{"key":"key-10.4103\/0929-6441.249634-6","first-page":"1194","volume-title":"Evaluation of a novel 7-joint ultrasound score in daily rheumatologic practice: A pilot project","author":"Backhaus","year":"2009","journal-title":"Arthritis Rheum"},{"key":"key-10.4103\/0929-6441.249634-7","first-page":"2303","volume-title":"Evaluation of pannus and vascularization of the metacarpophalangeal and proximal interphalangeal joints in rheumatoid arthritis by high-resolution ultrasound (multidimensional linear array)","author":"Hau","year":"1999","journal-title":"Arthritis Rheum"},{"key":"key-10.4103\/0929-6441.249634-8","first-page":"2811","volume-title":"Patient's global assessment of disease activity: What are we measuring?","author":"van","year":"2012","journal-title":"Arthritis Rheum"},{"key":"key-10.4103\/0929-6441.249634-9","first-page":"1139","volume-title":"Validity and reliability problems with patient global as a component of the ACR\/EULAR remission criteria as used in clinical practice","author":"Masri","year":"2012","journal-title":"J Rheumatol"},{"key":"key-10.4103\/0929-6441.249634-10","first-page":"382","volume-title":"Should oligoarthritis be reclassified.Ultrasound reveals a high prevalence of subclinical disease?","author":"Wakefield","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"key-10.4103\/0929-6441.249634-11","first-page":"19","volume-title":"Ultrasonography in arthritis of the knee.A comparison with MR imaging","author":"Ostergaard","year":"1995","journal-title":"Acta Radiol"},{"key":"key-10.4103\/0929-6441.249634-12","first-page":"401","volume-title":"Can imaging be used for inflammatory arthritis screening?","author":"\u00d8stergaard","year":"2012","journal-title":"Semin Musculoskelet Radiol"},{"key":"key-10.4103\/0929-6441.249634-13","first-page":"1959","volume-title":"Ultrasound evaluation of the acromioclavicular joint","author":"Alasaarela","year":"1997","journal-title":"J Rheumatol"},{"key":"key-10.4103\/0929-6441.249634-14","first-page":"1231","volume-title":"Detection of ankle effusions: Comparison study in cadavers using radiography, sonography, and MR imaging","author":"Jacobson","year":"1998","journal-title":"AJR Am J Roentgenol"},{"key":"key-10.4103\/0929-6441.249634-15","first-page":"387","volume-title":"Validation and reproducibility of ultrasonography in the detection of synovitis in the knee: A comparison with arthroscopy and clinical examination","author":"Karim","year":"2004","journal-title":"Arthritis Rheum"},{"key":"key-10.4103\/0929-6441.249634-16","doi-asserted-by":"crossref","unstructured":"Larch\u00e9 MJ, Seymour M, Lim A, Eckersley RJ, P\u00e9tavy F, Chiesa F, et al. Quantitative power Doppler ultrasonography is a sensitive measure of metacarpophalangeal joint synovial vascularity in rheumatoid arthritis and declines significantly following a 2-week course of oral low-dose corticosteroids. 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