{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T14:52:32Z","timestamp":1763563952095},"reference-count":20,"publisher":"Scientific Scholar","issue":"03","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":794,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurosciences in Rural Practice"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\nObjectives: To evaluate the pulmonary function in Guillain\ufffdBarre syndrome (GBS) patients in subacute phase and find clinical correlates of pulmonary dysfunction. Methods: This was a single-center, prospective, cross-sectional, hospital-based study in GBS patients performed in Department of Neurological Rehabilitation at a tertiary care institute. Clinical examination for pulmonary function was done by measuring chest expansion. The pulmonary function tests were carried out by Spirometry kit Microquark Cosmed, Italy. Fatigue was assessed by Fatigue Severity Scale, disability status by Hughes Disability Scale (HDS), and muscle weakness by Medical Research Council sum scores. Statistical Analysis: Statistical analysis was performed by Stata 11. The significance of P value was adjudged against an alpha of 0.05. Results: Twenty-eight patients were included with 17 (61%) men and mean age of 31 years. Median duration of symptoms was 16.5 days. There were 10 (36%) demyelinating and 18 (64%) axonal variants. Twenty-six (93%) patients scored more than 2 on HDS. All study participants reported fatigue. Twenty-two (78.6%) patients had chest expansion of &lt;2.5 cm. Spirometry showed restrictive pulmonary dysfunction in 23 (79%) patients. Significant correlation was found between abnormal pulmonary function test and chest expansion (P = 0.003). Conclusion: Pulmonary dysfunction in GBS is common even during subacute phase. It needs to be identified and managed appropriately for better clinical outcome.<\/jats:p>","DOI":"10.4103\/jnrp.jnrp_11_17","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T14:36:03Z","timestamp":1497364563000},"page":"412-416","source":"Crossref","is-referenced-by-count":4,"title":["Pulmonary Involvement in Patients with Guillain\u2013Barr\u00e9 Syndrome in Subacute Phase"],"prefix":"10.25259","volume":"08","author":[{"given":"Meeka","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Neurological Rehabilitation, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidhi","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Neurological Rehabilitation, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupam","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Neurological Rehabilitation, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhu","family":"Nagappa","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun B.","family":"Taly","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Rukmani","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. N.","family":"Sathyaprabha","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Partha","family":"Haldar","sequence":"additional","affiliation":[{"name":"Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"key-10.4103\/0976-3147.207952-1","first-page":"iii24","volume-title":"Long term ventilation in neurogenic respiratory failure","author":"Howard","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.4103\/0976-3147.207952-2","first-page":"415","volume-title":"Respiratory dysfunction in Guillain-Barr\u00e9 syndrome","author":"Orlikowski","year":"2004","journal-title":"Neurocrit Care"},{"key":"key-10.4103\/0976-3147.207952-3","first-page":"11","volume-title":"Respiratory management in acute neurologic illness","author":"Wijdicks","year":"1998","journal-title":"Neurology"},{"key":"key-10.4103\/0976-3147.207952-4","first-page":"1103","volume-title":"Interobserver agreement in the assessment of muscle strength and functional abilities in Guillain-Barr\u00e9 syndrome","author":"Kleyweg","year":"1991","journal-title":"Muscle Nerve"},{"key":"key-10.4103\/0976-3147.207952-5","first-page":"750","volume-title":"Controlled trial prednisolone in acute polyneuropathy","author":"Hughes","year":"1978","journal-title":"Lancet"},{"key":"key-10.4103\/0976-3147.207952-6","first-page":"99","volume-title":"Connecting impairment, disability, and handicap in immune mediated polyneuropathies","author":"Merkies","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.4103\/0976-3147.207952-7","first-page":"61","volume-title":"Amantadine for treatment of fatigue in Guillain-Barre syndrome: a randomised, double blind, placebo controlled, crossover trial","author":"Garssen","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.4103\/0976-3147.207952-8","first-page":"1143","volume-title":"Residual fatigue is independent of antecedent events and disease severity in Guillain-Barr\u00e9 syndrome","author":"Garssen","year":"2006","journal-title":"J Neurol"},{"key":"key-10.4103\/0976-3147.207952-9","first-page":"331","volume-title":"Prevalence of fatigue in Guillain-Barre Syndrome in neurological rehabilitation setting","author":"Ranjani","year":"2014","journal-title":"Ann Indian Acad Neurol","ISSN":"http:\/\/id.crossref.org\/issn\/0972-2327","issn-type":"print"},{"key":"key-10.4103\/0976-3147.207952-10","first-page":"36","volume-title":"Guillain-Barr\u00e9 syndrome: subtypes and predictors of outcome from India","author":"Kalita","year":"2014","journal-title":"J Peripher Nerv Syst"},{"key":"key-10.4103\/0976-3147.207952-11","first-page":"1021","volume-title":"Clinical and electrophysiological predictors of respiratory failure in Guillain-Barr\u00e9 syndrome: a prospective study","author":"Durand","year":"2006","journal-title":"Lancet Neurol"},{"key":"key-10.4103\/0976-3147.207952-12","first-page":"39","volume-title":"Electrophysiology to predict mechanical ventilation in Guillain-Barr\u00e9 syndrome","author":"Durand","year":"2003","journal-title":"Eur J Neurol"},{"key":"key-10.4103\/0976-3147.207952-13","first-page":"781","volume-title":"Prediction of respiratory insufficiency in Guillain-Barr\u00e9 syndrome","author":"Walgaard","year":"2010","journal-title":"Ann Neurol"},{"key":"key-10.4103\/0976-3147.207952-14","first-page":"893","volume-title":"Anticipating mechanical ventilation in Guillain-Barr\u00e9 syndrome","author":"Lawn","year":"2001","journal-title":"Arch Neurol"},{"key":"key-10.4103\/0976-3147.207952-15","first-page":"364","volume-title":"Tongue weakness is associated with respiratory failure in patients with severe Guillain-Barr\u00e9 syndrome","author":"Orlikowski","year":"2009","journal-title":"Acta Neurol Scand"},{"key":"key-10.4103\/0976-3147.207952-16","first-page":"336","volume-title":"Predictive factors and long-term outcome of respiratory failure after Guillain-Barr\u00e9 syndrome","author":"Cheng","year":"2004","journal-title":"Am J Med Sci"},{"key":"key-10.4103\/0976-3147.207952-17","first-page":"60","volume-title":"Clinical predictors of mechanical ventilation in Fisher\/Guillain-Barr\u00e9 overlap syndrome","author":"Funakoshi","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.4103\/0976-3147.207952-18","unstructured":"Garth PJ. 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