{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:47:37Z","timestamp":1785577657214,"version":"3.56.0"},"reference-count":34,"publisher":"Scientific Scholar","issue":"03","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":794,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurosciences in Rural Practice"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\nObjective: The objective of this study was to describe the demographic features, clinical presentation, and management and outcome of fifty cases of nonalcoholic Wernicke\u2019s encephalopathy from a tertiary care hospital of a region with reported incidence of thiamine deficiency disorders. Materials and Methods: In a retrospective study, fifty adult cases of Wernicke\u2019s encephalopathy were analyzed. The diagnosis of Wernicke\u2019s encephalopathy was made according to the European federation of neurological societies guidelines 2010. Response to thiamine replacement and associated brain magnetic resonance imaging (MRI) findings were also considered as supportive evidence. Results: The mean age of patients was 50.38 years with 20 males and 30 females. The most common clinical manifestations were alteration in sensorium in 30 (60%), ataxia in 18 (36%), memory impairment in 15 (30%), nystagmus in 35 (70%), ophthalmoparesis in 11 (22%), and seizures in 4 (8%). A total of 42 patients had a history of recurrent vomiting. All patients had polished rice as their staple diet. Thirty-five patients had associated polyneuropathy and 15 had a gastrointestinal disorder. Twenty patients underwent MRI which showed both typical and atypical lesions. Majority of patients showed partial or complete response to intravenous thiamine. On discharge, the most common residual symptoms were lower limb weakness, ataxia, and memory impairment. Conclusion: The study shows high incidence of nonalcoholic Wernicke\u2019s encephalopathy in the region with predominant causative factor being a thiamine deficient diet. Recurrent vomiting can be a prominent early symptom of thiamine deficiency and its recognition can help in the early diagnosis of Wernicke\u2019s encephalopathy and related thiamine deficiency disorders. Thiamine fortification of food should be done in areas with reported incidence of thiamine deficiency disorders.<\/jats:p>","DOI":"10.4103\/jnrp.jnrp_14_17","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T14:36:03Z","timestamp":1497364563000},"page":"401-406","source":"Crossref","is-referenced-by-count":26,"title":["Nonalcoholic Wernicke\u2019s Encephalopathy: A Retrospective Study from a Tertiary Care Center in Northern India"],"prefix":"10.25259","volume":"08","author":[{"given":"Irfan Ahmad","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravouf Parvaiz","family":"Asimi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuman","family":"Kawoos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Government Medical College, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maqbool","family":"Wani","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahir","family":"Saleem","sequence":"additional","affiliation":[{"name":"Department of Olericulture, Sher-e-Kashmir University of Agricultural Sciences and Technology, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waqas Nabi","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Food Sciences and Technology, University of Kashmir, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"key-10.4103\/0976-3147.207956-1","unstructured":"Victor M. The Wernicke-Korsakoff syndrome. In: Vinken PJ, Bruyn GW, editors. Handbook of Clinical Neurology. Part II. Vol. 28. Amsterdam: North-Holland Publishing Company; 1976. p. 243-70."},{"key":"key-10.4103\/0976-3147.207956-2","first-page":"555","volume-title":"Nutrition and alcohol neurotoxicity","author":"Manzo","year":"1994","journal-title":"Neurotoxicology"},{"key":"key-10.4103\/0976-3147.207956-3","unstructured":"Harper C, Butterworth R. Nutritional and metabolic disorders. In: Graham DI, Lantos PL, editors. Greenfield's Neuropathology. 6th ed., Vol. 1. 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