{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:05:29Z","timestamp":1781737529167,"version":"3.54.5"},"reference-count":16,"publisher":"Scientific Scholar","issue":"02","license":[{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"vor","delay-in-days":519,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurosciences in Rural Practice"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          Background: Parkinson's disease (PD) is a chronic neurodegenerative pathology with unknown etiology. It is characterized clinically by the classic triad that associated tremors, bradykinesia, and rigidity. In Niger, there are no data on PD. Aims: We aimed to provide the demographic and clinical profile of PD in patients from Niger to create a database on PD in Niger. Patients and Methods: We conducted a retrospective study at the Neurology Outpatient Clinic of the H\u00f4pital National de Niamey (HNN, Niger) over a period of 4.42 years from February 2009 to July 2013 collecting all cases of PD. The demographic and clinical features of all patients were collected and analyzed. Results: During the period of the study, 1695 patients consulted at the Neurology Outpatient Clinic of the HNN, among which 76 patients (4.48%) had secondary parkinsonism and 25 patients (1.47%) had features compatible with PD. Only patients with PD were included in this study. The mean age at onset of symptoms was 58 years (range: 42\u201374 years). The male sex was predominant (60%) with a sex ratio of 1.5. The mean time interval from the onset of symptoms to diagnosis of PD was 1.8 years (range: 1\u20135 years). The tremor was the most common symptom (84%). Bradykinesia represented 64% of the symptoms and rigidity 20%. At the time of the diagnosis of PD, 8 patients (32%) were in Stage I of the classification of Hoehn and Yahr, 16 patients (64%) in Stage II, and 1 patient (4%) in Stage III. The levodopa\/carbidopa combination was the most used antiparkinsonian drug in our patients (88%). The mean time of follow-up of the patients was 2.5 years (range: 1\u20134.42 years). During the course of the disease, 9 patients (36%) were in Stage II of the classification of Hoehn and Yahr, 13 patients (52%) in Stage III, and 3 patients (12%) in Stage IV. Conclusion: Our study provides demographic and clinical data of PD in patients from Niger and shows that the hospital frequency of this disease is low (1.47%). The demographic and clinical features of our patients are similar to those of the patients of the prior studies reported in sub-Saharan Africa.<\/jats:p>","DOI":"10.4103\/jnrp.jnrp_337_17","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T12:20:06Z","timestamp":1523449206000},"page":"214-218","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Profile of Parkinson's Disease: Experience of Niger"],"prefix":"10.25259","volume":"09","author":[{"given":"Hamid","family":"Assadeck","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialties, National Hospital of Niamey, Niger"},{"name":"Faculty of Medicine and Pharmacy, Abdou Moumouni University, Niamey, Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moussa Toudou","family":"Daouda","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialties, National Hospital of Niamey, Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatimata Hassane","family":"Djibo","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialties, National Hospital of Niamey, Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djibo Douma","family":"Maiga","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialties, National Hospital of Niamey, Niger"},{"name":"Faculty of Medicine and Pharmacy, Abdou Moumouni University, Niamey, Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Adehossi","family":"Omar","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialties, National Hospital of Niamey, Niger"},{"name":"Faculty of Medicine and Pharmacy, Abdou Moumouni University, Niamey, Niger"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2019,9,2]]},"reference":[{"key":"key-10.4103\/0976-3147.229531-1","unstructured":"Parkinson J. An Essay on the Shaking Palsy. London: Sherwood, Nelly and Jones; 1817."},{"key":"key-10.4103\/0976-3147.229531-2","first-page":"1","volume-title":"Clinical profile of parkinsonism and Parkinson's disease in Lagos, Southwestern Nigeria","author":"Okubadejo","year":"2010","journal-title":"BMC Neurol"},{"key":"key-10.4103\/0976-3147.229531-3","first-page":"237","volume-title":"Clinical profile of parkinsonian disorders in the tropics: Experience at Kano, Northwestern Nigeria","author":"Femi","year":"2012","journal-title":"J Neurosci Rural Pract","ISSN":"https:\/\/id.crossref.org\/issn\/0976-3147","issn-type":"print"},{"key":"key-10.4103\/0976-3147.229531-4","first-page":"S5","volume-title":"Advanced Parkinson's disease","author":"Zi\u00e9gler","year":"2006","journal-title":"Psychol NeuroPsychiatr Vieil"},{"key":"key-10.4103\/0976-3147.229531-5","first-page":"121","volume-title":"Stages in the development of Parkinson's disease-related pathology","author":"Braak","year":"2004","journal-title":"Cell Tissue Res"},{"key":"key-10.4103\/0976-3147.229531-6","unstructured":"National Institute of Statistic (NIS) and ICF International. Demographic and Health Survey and Multiple Indicators of Niger 2012. Calverton, Maryland, USA: NIS and ICF International; 2013."},{"key":"key-10.4103\/0976-3147.229531-7","first-page":"181","volume-title":"Accuracy of clinical diagnosis of idiopathic Parkinson's disease: A clinico-pathological study of 100 cases","author":"Hughes","year":"1992","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.4103\/0976-3147.229531-8","first-page":"427","volume-title":"Parkinsonism: Onset, progression and mortality","author":"Hoehn","year":"1967","journal-title":"Neurology"},{"key":"key-10.4103\/0976-3147.229531-9","first-page":"276","volume-title":"Prevalence of Parkinson's disease in Estonia","author":"Taba","year":"2002","journal-title":"Acta Neurol Scand"},{"key":"key-10.4103\/0976-3147.229531-10","first-page":"182","volume-title":"Prevalence of Parkinson's disease and atypical Parkinsonian syndromes in a rural Japanese district","author":"Osaki","year":"2011","journal-title":"Acta Neurol Scand"},{"key":"key-10.4103\/0976-3147.229531-11","first-page":"645","volume-title":"Comparison of the prevalence of Parkinson's disease in black populations in the rural United States and in rural Nigeria: Door-to-door community studies","author":"Schoenberg","year":"1988","journal-title":"Neurology"},{"key":"key-10.4103\/0976-3147.229531-12","first-page":"1075","volume-title":"Clinical spectrum of Parkinson's disease from Pakistan","author":"Khealani","year":"2006","journal-title":"Singapore Med J"},{"key":"key-10.4103\/0976-3147.229531-13","first-page":"49","volume-title":"Risk factors of Parkinson's disease in Indian patients","author":"Behari","year":"2001","journal-title":"J Neurol Sci"},{"key":"key-10.4103\/0976-3147.229531-14","first-page":"317","volume-title":"Epidemiology of Parkinson's disease","author":"Tanner","year":"1996","journal-title":"Neurol Clin"},{"key":"key-10.4103\/0976-3147.229531-15","first-page":"805","volume-title":"Prevalence and age of onset of Parkinson's disease in cardiff: A community based cross sectional study and meta-analysis","author":"Wickremaratchi","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key-10.4103\/0976-3147.229531-16","first-page":"292","volume-title":"Female preponderance of Parkinson's disease in Japan","author":"Kimura","year":"2002","journal-title":"Neuroepidemiology"}],"container-title":["Journal of Neurosciences in Rural Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/jnrp.jnrp_337_17.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T04:17:27Z","timestamp":1691209047000},"score":1,"resource":{"primary":{"URL":"https:\/\/ruralneuropractice.com\/clinical-profile-of-parkinsons-disease-experience-of-niger\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":16,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2019,9,2]]},"published-print":{"date-parts":[[2018,4]]}},"URL":"https:\/\/doi.org\/10.4103\/jnrp.jnrp_337_17","relation":{},"ISSN":["0976-3147","0976-3155"],"issn-type":[{"value":"0976-3147","type":"print"},{"value":"0976-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4]]}}}