{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:39:23Z","timestamp":1787164763684,"version":"build-2736575974"},"reference-count":10,"publisher":"Scientific Scholar","issue":"03","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":794,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurosciences in Rural Practice"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Myeloid sarcoma (MS) or chloroma is a rare extramedullary tumor composed of extramedullary proliferation of blasts of granulocytic, monocytic, erythroid, or megakaryocytic lineage occurring at sites outside the bone marrow. MS occurs in 2%\u20138% of patients with acute myeloid leukemia (AML), sometimes it occurs as the presenting manifestation of relapse in a patient in remission. We describe the case of a young male with AML in remission for 6 years presenting with central nervous system symptoms. Magnetic resonance imaging showed an extra-axial altered intensity lesion in the parasagittal parietal region, infiltrating anterosuperiorly into anterior falx, and posterosuperior aspect of the superior sagittal sinus. A biopsy from the lesion was diagnostic of MS which was positive for myeloperoxidase. He did not have any other sites of disease. He has received chemotherapy with FLAG (Fludarabine, Cytosine arabinoside) followed by cranial irradiation and is in complete remission.<\/jats:p>","DOI":"10.4103\/jnrp.jnrp_376_16","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T10:36:03Z","timestamp":1497350163000},"page":"466-468","source":"Crossref","is-referenced-by-count":7,"title":["Isolated Intracranial Myeloid Sarcoma Occurring as Relapse in Acute Myeloid Leukemia"],"prefix":"10.25259","volume":"08","author":[{"given":"Geetha","family":"Narayanan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lali V.","family":"Soman","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Haridas","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Sugathan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"key-10.4103\/0976-3147.207965-1","first-page":"1370","volume-title":"Myeloid sarcoma is associated with superior event-free survival and overall survival compared with acute myeloid leukemia","author":"Tsimberidou","year":"2008","journal-title":"Cancer"},{"key":"key-10.4103\/0976-3147.207965-2","first-page":"340","volume-title":"Myeloid sarcoma: Clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients","author":"Pileri","year":"2007","journal-title":"Leukemia"},{"key":"key-10.4103\/0976-3147.207965-3","first-page":"1426","volume-title":"Granulocytic sarcoma: A clinicopathologic study of 61 biopsied cases","author":"Neiman","year":"1981","journal-title":"Cancer"},{"key":"key-10.4103\/0976-3147.207965-4","first-page":"238","volume-title":"Prognostic factors of treatment outcomes in patients with granulocytic sarcoma","author":"Lan","year":"2009","journal-title":"Acta Haematol"},{"key":"key-10.4103\/0976-3147.207965-5","first-page":"1100","volume-title":"Outcome in patients with nonleukemic granulocytic sarcoma treated with chemotherapy with or without radiotherapy","author":"Tsimberidou","year":"2003","journal-title":"Leukemia"},{"key":"key-10.4103\/0976-3147.207965-6","first-page":"916","volume-title":"Myeloid sarcoma with multiple lesions of the central nervous system in a patient without leukemia.Case report","author":"Widhalm","year":"2006","journal-title":"J Neurosurg"},{"key":"key-10.4103\/0976-3147.207965-7","first-page":"1102","volume-title":"Intracranial CNS manifestations of myeloid sarcoma in patients with acute myeloid leukemia: Review of the literature and three case reports from the author's institution","author":"Cervantes","year":"2015","journal-title":"J Clin Med"},{"key":"key-10.4103\/0976-3147.207965-8","unstructured":"\u00d8stgaard LS, Sengel\u00f8v H, Holm MS, Johnsen HE, Severinsen MT, Kjeldsen E, et al. Extramedullary Leukemia and Myeloid Sarcoma in AML: New Clues to an Old Issue. Results of a Retrospective Population-Based Registry-Study of 2261 Patients; Annals of 53rd American Society of Hematology Annual Meeting and Exposition; 2011, San Diego, CA, USA; 10-13 December, 2011."},{"key":"key-10.4103\/0976-3147.207965-9","first-page":"311","volume-title":"Isolated recurrence of granulocytic sarcoma manifesting as extra- and intracranial masses \u2013 Case report","author":"Nishimura","year":"2004","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"key-10.4103\/0976-3147.207965-10","first-page":"1165","volume-title":"Clinico-pathological characteristics of myeloid sarcoma at diagnosis and during follow-up: Report of 12 cases from a single institution","author":"Breccia","year":"2004","journal-title":"Leuk Res"}],"container-title":["Journal of Neurosciences in Rural Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/jnrp.jnrp_376_16.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T00:18:39Z","timestamp":1691194719000},"score":1,"resource":{"primary":{"URL":"https:\/\/ruralneuropractice.com\/isolated-intracranial-myeloid-sarcoma-occurring-as-relapse-in-acute-myeloid-leukemia\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":10,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2019,9,3]]},"published-print":{"date-parts":[[2017,7]]}},"URL":"https:\/\/doi.org\/10.4103\/jnrp.jnrp_376_16","relation":{},"ISSN":["0976-3147","0976-3155"],"issn-type":[{"value":"0976-3147","type":"print"},{"value":"0976-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7]]}}}