{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:11:47Z","timestamp":1791821507898,"version":"4.3.4"},"reference-count":15,"publisher":"Scientific Scholar","issue":"02","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":886,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurosciences in Rural Practice"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          Introduction: Thrombolytic therapy in acute ischemic stroke has been approved for treatment of acute stroke for past two decades. However, identification of predictors of poor outcome after the intravenous (IV) alteplase therapy in acute stroke patients is a matter of research. The present study was conducted with the aim of identifying poor prognostic factors in patients of acute ischemic stroke patients. Methods: The data of 31 acute stroke patients treated with alteplase were gathered to identify the factors that were independent predictors of the poor outcome. Outcome was dichotomized using modified Rankin scale (mRS) score and National Institutes of Health Stroke Scale (NIHSS) score at 3 months after treatment into good outcome mRS - 0\u20132 and poor outcome mRS - 3\u20136. Predictors of poor outcome were analyzed. Results: Good outcome (mRS \u2013 score 0\u20132) was seen in 15 (48.4%) patients with median age of (60) and poor outcome (mRS \u2013 score 3\u20136) was seen in 16 (51.6%) patients median age of 75 years, which was statistically significant with the P = 0.002. The presence of risk factors such as hypertension, diabetes, dyslipidemia, smoking, alcohol intake, history of stroke, coronary artery disease, and rheumatic heart disease among the two groups did not seem influence outcome. The severity of stroke as assessed by NIHSS score at the time of presentation was significantly higher among the patients with poor outcome, with P = 0.01. Conclusion: Advance age and higher NIHSS score at the time of onset of stroke and are the independent predictors of the poor outcome after thrombolysis with IV alteplase treatment in acute ischemic stroke patients.<\/jats:p>","DOI":"10.4103\/jnrp.jnrp_431_16","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T13:45:47Z","timestamp":1491399947000},"page":"236-240","source":"Crossref","is-referenced-by-count":13,"title":["Advanced Age and Higher National Institutes of Health Stroke Scale Score as Predictors of Poor Outcome in Ischemic Stroke Patients Treated with Alteplase: A Study from a Tertiary Care Centre in Rural North-west India"],"prefix":"10.25259","volume":"08","author":[{"given":"Amit","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dr. RPGMC, Tanda, Kangra, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dr. RPGMC, Tanda, Kangra, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil Kumar","family":"Raina","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Dr. RPGMC, Tanda, Kangra, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dr. RPGMC, Tanda, Kangra, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Angra","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dr. RPGMC, Tanda, Kangra, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"key-10.4103\/0976-3147.203835-1","first-page":"212","volume-title":"Stroke: A case review","author":"Meister","year":"2000","journal-title":"Clin Excell Nurse Pract"},{"key":"key-10.4103\/0976-3147.203835-2","first-page":"461","volume-title":"Oxidative stress and its role in the pathogenesis of ischaemic stroke","author":"Allen","year":"2009","journal-title":"Int J Stroke"},{"key":"key-10.4103\/0976-3147.203835-3","first-page":"99","volume-title":"Modern medical management of acute ischemic stroke","author":"Goldstein","year":"2014","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"key-10.4103\/0976-3147.203835-4","first-page":"1317","volume-title":"Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke","author":"Hacke","year":"2008","journal-title":"N Engl J Med"},{"key":"key-10.4103\/0976-3147.203835-5","first-page":"1695","volume-title":"Time to treatment with intravenous alteplase and outcome in stroke: An updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials","author":"Lees","year":"2010","journal-title":"Lancet"},{"key":"key-10.4103\/0976-3147.203835-6","first-page":"122","volume-title":"Poor outcome after first-ever stroke: Predictors for death, dependency, and recurrent stroke within the first year","author":"Appelros","year":"2003","journal-title":"Stroke"},{"key":"key-10.4103\/0976-3147.203835-7","first-page":"1114","volume-title":"Sex differences in the clinical presentation, resource use, and 3-month outcome of acute stroke in Europe: Data from a multicenter multinational hospital-based registry","author":"Di","year":"2003","journal-title":"Stroke"},{"key":"key-10.4103\/0976-3147.203835-8","doi-asserted-by":"crossref","unstructured":"Howard G, Walker MD, Becker C, Coull B, Feibel J, McLeroy K, et al. Community hospital-based stroke programs: North Carolina, Oregon, and New York. III. Factors influencing survival after stroke: Proportional hazards analysis of 4219 patients. 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Baseline NIH stroke scale score strongly predicts outcome after stroke: A report of the trial of Org 10172 in acute stroke treatment (TOAST)","author":"Adams","year":"1999","journal-title":"Neurology"}],"container-title":["Journal of Neurosciences in Rural Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/jnrp.jnrp_431_16.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T04:18:52Z","timestamp":1691209132000},"score":1,"resource":{"primary":{"URL":"https:\/\/ruralneuropractice.com\/advanced-age-and-higher-national-institutes-of-health-stroke-scale-score-as-predictors-of-poor-outcome-in-ischemic-stroke-patients-treated-with-alteplase-a-study-from-a-tertiary-care-centre-in-rural\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":15,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2019,9,4]]},"published-print":{"date-parts":[[2017,4]]}},"URL":"https:\/\/doi.org\/10.4103\/jnrp.jnrp_431_16","relation":{},"ISSN":["0976-3147","0976-3155"],"issn-type":[{"value":"0976-3147","type":"print"},{"value":"0976-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}