{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:14:57Z","timestamp":1783656897714,"version":"3.55.0"},"reference-count":20,"publisher":"Scientific Scholar","issue":"01","license":[{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"vor","delay-in-days":609,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurosciences in Rural Practice"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          Introduction: Leprosy affecting the nerve solely or with concomitant skin lesions is not an uncommon condition in clinical practice. It is responsible for extensive morbidity and often poses a diagnostic challenge. This study aims to highlight the clinicopathological features of Hansen's neuritis (HN). Materials and Methods: In this retrospective study, cases of histologically diagnosed HN, from January 2010 to July 2017, were reviewed in the light of clinical features, treatment history, and outcome. Results: There were 18 cases of HN which accounted for 3.97% of total nerve biopsy samples (n = 453) and 0.02% of total histopathology samples (n = 81,013). The male: female ratio was 5:1 in the cases of HN. Age range was 20\u201379 years with a mean age of 42.4 years (standard deviation: \u00b114.03). Among the HN cases, there were 13 cases of pure neuritic leprosy (61.1%). Mononeuritis multiplex was the most common finding in the nerve conduction study. Six (33.3%) cases exhibited histological features of borderline tuberculoid leprosy, followed by five (27.8%) cases of mid-borderline features, three (16.7%) cases each of borderline lepromatous and burnt-out HN, and one (5.6%) case of polar tuberculoid leprosy. Lepra bacilli were detected on Fite-Faraco stain in 44.4% cases. Conclusion: Diagnosis of HN depends on astute search for skin lesions, nerve thickening or tenderness, sensory or motor symptoms, histopathological examination, and demonstration of lepra bacilli.<\/jats:p>","DOI":"10.4103\/jnrp.jnrp_438_17","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T09:40:49Z","timestamp":1516354849000},"page":"042-055","source":"Crossref","is-referenced-by-count":6,"title":["Hansen's Neuritis Revisited \u2013 A Clinicopathological Study"],"prefix":"10.25259","volume":"09","author":[{"given":"Navya","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrijeet","family":"Chakraborti","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashinath","family":"Nayak","sequence":"additional","affiliation":[{"name":"Dermatology and Kasturba Medical College, Manipal University, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivananda","family":"Pai","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. P.","family":"Shelley","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yenepoya Medical College, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saraswathy P.","family":"Sreeram","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. C.","family":"Rakshith","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. V.","family":"Suresh","sequence":"additional","affiliation":[{"name":"Department of Neurology, AJ Institute of Medical Sciences, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. K.","family":"Misri","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansraj","family":"Alva","sequence":"additional","affiliation":[{"name":"Vinaya Hospital and Research Centre, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Shankar","sequence":"additional","affiliation":[{"name":"Mallikatta Neuro Center, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2019,9,2]]},"reference":[{"key":"key-10.4103\/0976-3147.223520-1","first-page":"255","volume-title":"Classification of leprosy according to immunity.A five-group system","author":"Ridley","year":"1966","journal-title":"Int J Lepr Other Mycobact Dis"},{"key":"key-10.4103\/0976-3147.223520-2","first-page":"252","volume-title":"Pure neuritic leprosy: Current status and relevance","author":"Rao","year":"2016","journal-title":"Indian J Dermatol Venereol Leprol","ISSN":"https:\/\/id.crossref.org\/issn\/0378-6323","issn-type":"print"},{"key":"key-10.4103\/0976-3147.223520-3","unstructured":"Ridley DS. Bacterial indices. In: Cochrane RG, Davey TF, editors. Leprosy in Theory and Practice. Bristol: John Wright and Sons Ltd.; 1964. p. 620-2."},{"key":"key-10.4103\/0976-3147.223520-4","first-page":"629","volume-title":"Leprosy","author":"Sehgal","year":"1994","journal-title":"Dermatol Clin"},{"key":"key-10.4103\/0976-3147.223520-5","doi-asserted-by":"crossref","unstructured":"Prasad PV, editor. All about Leprosy. New Delhi: Jaypee Brothers Medical Publishers (P) Ltd.; 2005.","DOI":"10.5005\/jp\/books\/10037"},{"key":"key-10.4103\/0976-3147.223520-6","unstructured":"WHO Seventh Expert Committee; June, 1997. Available from: http:\/\/www.who.int\/lep\/resources\/expert\/en\/index1.html. [Last accessed on 2017 Aug 26]."},{"key":"key-10.4103\/0976-3147.223520-7","unstructured":"World Health Organization. WHO Expert Committee on Leprosy: Eighth report. Geneva: World Health Organization; 2012. p. 11-2."},{"key":"key-10.4103\/0976-3147.223520-8","first-page":"87","volume-title":"Hot topics in leprosy","author":"Handa","year":"2003","journal-title":"Lepr Rev"},{"key":"key-10.4103\/0976-3147.223520-9","unstructured":"National Leprosy Eradication Programme Training Manual for Medical Officer, Central Leprosy Division, Directorate General Of Health Services, Ministry of Health and Family Welfare (Government of India), Nirman Bhavan, New Delhi; 2013."},{"key":"key-10.4103\/0976-3147.223520-10","unstructured":"World Health Organization. Global Leprosy Strategy 2016-2020: Accelerating towards a Leprosy-Free world. Geneva: World Health Organization; 2016. p. 3-4."},{"key":"key-10.4103\/0976-3147.223520-11","unstructured":"Sharma VK, Malhotra AK. Leprosy: Classification and clinical aspects. In: Valia RG, Valia AR, editors. IADVL Text Book of Dermatology. 3rd ed. Mumbai: Bhalani Publishing House; 2008. p. 2032-69."},{"key":"key-10.4103\/0976-3147.223520-12","first-page":"261","volume-title":"Primary neuritic leprosy: A reappraisal at a tertiary care hospital","author":"Mendiratta","year":"2006","journal-title":"Indian J Lepr"},{"key":"key-10.4103\/0976-3147.223520-13","first-page":"292","volume-title":"Pure neuritic leprosy: Resolving diagnostic issues in acid fast bacilli (AFB)-negative nerve biopsies: A single centre experience from South India","author":"Hui","year":"2015","journal-title":"Ann Indian Acad Neurol","ISSN":"https:\/\/id.crossref.org\/issn\/0972-2327","issn-type":"print"},{"key":"key-10.4103\/0976-3147.223520-14","first-page":"806","volume-title":"Criteria for diagnosis of pure neural leprosy","author":"Jardim","year":"2003","journal-title":"J Neurol"},{"key":"key-10.4103\/0976-3147.223520-15","first-page":"1178","volume-title":"Leprosy of the oral cavity and adnexa","author":"Lighterman","year":"1962","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"key-10.4103\/0976-3147.223520-16","first-page":"401","volume-title":"A comparative evaluation of skin and nerve histopathology in single skin lesion leprosy","author":"Reddy","year":"2005","journal-title":"Indian J Dermatol Venereol Leprol","ISSN":"https:\/\/id.crossref.org\/issn\/0378-6323","issn-type":"print"},{"key":"key-10.4103\/0976-3147.223520-17","first-page":"246","volume-title":"Histopathological examination of nerve samples from pure neural leprosy patients: Obtaining maximum information to improve diagnostic efficiency","author":"Antunes","year":"2012","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"key-10.4103\/0976-3147.223520-18","first-page":"1071","volume-title":"An immunohistochemical, clinical and electroneuromyographic correlative study of the neural markers in the neuritic form of leprosy","author":"Antunes","year":"2006","journal-title":"Braz J Med Biol Res"},{"key":"key-10.4103\/0976-3147.223520-19","first-page":"982","volume-title":"Hansen disease in the United States in the 21st century: A review of the literature","author":"Anderson","year":"2007","journal-title":"Arch Pathol Lab Med"},{"key":"key-10.4103\/0976-3147.223520-20","first-page":"138","volume-title":", Balagon MV, Abalos RM, et al. Detection of phenolic glycolipid I of Mycobacterium leprae in sera from leprosy patients before and after start of multidrug therapy","author":"Cho","year":"2001","journal-title":"Clin Diagn Lab Immunol"}],"container-title":["Journal of Neurosciences in Rural Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/jnrp.jnrp_438_17.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T04:17:40Z","timestamp":1691209060000},"score":1,"resource":{"primary":{"URL":"https:\/\/ruralneuropractice.com\/hansens-neuritis-revisited-a-clinicopathological-study\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":20,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2019,9,2]]},"published-print":{"date-parts":[[2018,1]]}},"URL":"https:\/\/doi.org\/10.4103\/jnrp.jnrp_438_17","relation":{},"ISSN":["0976-3147","0976-3155"],"issn-type":[{"value":"0976-3147","type":"print"},{"value":"0976-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}