{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:23:18Z","timestamp":1787768598725,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aims:<\/jats:title>\n \n Cardiac surgery often necessitates considerable post-operative vasoactive-inotropic support. Given an encouraging literature on the prognostic potential of leucoglycemic index (LGI) [serum glucose (mg\/dl) \u00d7 total leucocytes count (cells\/mm\n 3<\/jats:sup>\n )\/1000], we aimed to evaluate whether intensive care unit (ICU)-admission LGI can predict post-operative vasopressor-inotropic requirements following cardiac surgery on cardio-pulmonary bypass (CPB).\n <\/jats:p>\n <\/jats:sec>\n \n Material and Methods:<\/jats:title>\n \n The data of patients undergoing cardiac surgery at our tertiary care center between January 2015 and December 2020 was retrospectively reviewed. The vasopressor-inotropic requirement was estimated using the VIS (vasoactive-inotropic score) values over the first post-operative 72 hrs. Subsequently, VIS\n i<\/jats:sub>\n (indexed VIS) was computed as maxVIS\n [0-24hrs]<\/jats:sub>\n + maxVIS\n [24-48hrs]<\/jats:sub>\n +2 \u00d7 maxVIS\n [48-72hrs]<\/jats:sub>\n \/10), and the study participants were divided into h-VIS\n i<\/jats:sub>\n (VIS\n i<\/jats:sub>\n \u22653) and l-VIS\n i<\/jats:sub>\n (VIS\n i<\/jats:sub>\n <3).\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Out of 2138 patients, 479 (22.40%) patients categorized as h-VIS\n i<\/jats:sub>\n . On univariate analysis: LGI, age, European System for Cardiac Operative Risk Evaluation score (EuroSCORE II), left-ventricle ejection fraction, prior congestive heart failure (CHF), chronic renal failure, angiotensin-converting enzyme inhibitors, combined surgeries, CPB and aortic cross-clamp (ACC) duration, blood transfusion, and immediate post-operative glucose were significant h-VIS\n i<\/jats:sub>\n predictors. Subsequent to multi-variate analysis, the predictive performance of LGI (OR: 1.09; 95% CI: 1.03\u20131.14;\n P<\/jats:italic>\n = 0.002) prior CHF (OR: 2.35; 95% CI: 1.44\u20133.82;\n P<\/jats:italic>\n = 0.001), CPB time (OR: 1.08; 95% CI: 1.02\u20131.14;\n P<\/jats:italic>\n = 0.019), ACC time (OR: 1.03; 95% CI: 1.02\u20131.04;\n P<\/jats:italic>\n = 0.008), and EuroSCORE II (OR: 1.14; 95% CI: 1.06\u20131.21;\n P<\/jats:italic>\n < 0.001) remained significant. With 1484.75 emerging as the h-VIS\n i<\/jats:sub>\n predictive cut-off, patients with LGI \u2265 1484.75 also had a higher incidence of vasoplegia, low-cardiac output syndrome, new-onset atrial fibrillation, acute kidney injury, and mortality. LGI additionally exhibited a significant positive correlation with duration of mechanical ventilation and ICU stay (R = 0.495 and 0.564,\n P<\/jats:italic>\n value < 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n An elevated LGI of greater than 1484.75 independently predicted a VISindex \u22653 following adult cardiac surgery on CPB.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/joacp.joacp_100_22","type":"journal-article","created":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T18:00:16Z","timestamp":1706464816000},"page":"48-55","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Leucoglycemic index predicts post-operative vasopressor-inotropic requirement after adult cardiac surgery (LEUCOGLYPTICS): A retrospective single-center study"],"prefix":"10.4103","volume":"40","author":[{"given":"Rohan","family":"Magoon","sequence":"first","affiliation":[{"name":"Department of Cardiac Anaesthesia, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armaanjeet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anaesthesia, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Kashav","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anaesthesia, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasvinder K.","family":"Kohli","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anaesthesia, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iti","family":"Shri","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anaesthesia, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noopur","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anaesthesia, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Grover","sequence":"additional","affiliation":[{"name":"Cardiothoracic and Vascular Surgery, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital, New Delhi, 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