{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:28:36Z","timestamp":1786739316482,"version":"build-2736575974"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,10]]},"abstract":"\n Background and Aims:<\/jats:title>\n Ventilation can induce increase in inflammatory mediators that may contribute to systemic organ dysfunction. Ventilation-induced organ dysfunction is likely to be accentuated if there is a pre-existing systemic inflammatory response.<\/jats:p>\n <\/jats:sec>\n \n Material and Methods:<\/jats:title>\n \n Adult patients suffering from intestinal perforation peritonitis-induced systemic inflammatory response syndrome and scheduled for emergency laparotomy were randomized to receive intraoperative ventilation with 10 ml.kg\n -1<\/jats:sup>\n tidal volume (Group H) versus lower tidal volume of 6 ml.kg\n -1<\/jats:sup>\n along with positive end-expiratory pressure (PEEP) of 10 cmH\n 2<\/jats:sub>\n O (Group L), (\n n<\/jats:italic>\n = 45 each). The primary outcome was postoperative organ dysfunction evaluated using the aggregate Sepsis-related Organ Failure Assessment (SOFA) score. The secondary outcomes were, inflammatory mediators viz. interleukin-6, tumor necrosis factor-\u03b1, procalcitonin, and C-reactive protein, assessed prior to (basal) and 1 h after initiation of mechanical ventilation, and 18 h postoperatively.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The aggregate SOFA score (3[1\u20133] vs. 1[1\u20133]); and that on the first postoperative day (2[1\u20133] vs. 1[0\u20133]) were higher for group L as compared to group H (\n P<\/jats:italic>\n < 0.05). All inflammatory mediators were statistically similar between both groups at all time intervals (\n P<\/jats:italic>\n > 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n Mechanical ventilation with low tidal volume of 6 ml\/kg\n -1<\/jats:sup>\n along with PEEP of 10 cmH\n 2<\/jats:sub>\n O is associated with significantly worse postoperative organ functions as compared to high tidal volume of 10 ml.kg\n -1<\/jats:sup>\n in patients of perforation peritonitis-induced systemic inflammation undergoing emergency laparotomy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/joacp.joacp_112_18","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T03:11:30Z","timestamp":1576206690000},"page":"460-467","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Low tidal volume ventilation strategy and organ functions in patients with pre-existing systemic inflammatory 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