{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:37:27Z","timestamp":1787071047589,"version":"build-2736575974"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>Providing postoperative pain management in patients who underwent scrotal surgeries is achieved using several methods, one of which is the ultrasound-guided spermatic cord block (US-SCB). To enhance anesthesia quality and extend analgesia postoperatively, several agents have been added in conjunction with local agents. This study targeted assessing the results of combining neostigmine with levobupivacaine in US-SCB for providing perioperative analgesia in patients undergoing testicular sperm extraction (TESE) surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>This double-blind, randomized controlled study was performed for 112 subjects undergoing TESE operation using general anesthesia. They were randomly and equally divided into two groups. All participants received bilateral US-SCB after induction of general anesthesia by 19 mL of levobupivacaine 0.5% combined with 1 mL of neostigmine 500 \u03bcg in (group N) or 1 mL of normal saline in (group C). The first analgesic dose request time and the amount of analgesic consumed in the first 24 h were the main points of comparison in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean postoperative analgesia duration was noticeably increased in the N group compared to the C group, with a value of 480 \u00b1 41.34 min versus 404 \u00b1 34.14 min, independently (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Moreover, the total amount of postoperative analgesic consumption was remarkably decreased in group N when compared to group C without statistically remarkable divergence concerning complications between both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Adding neostigmine to a local anesthetic solution in US-SCB proved to detain the first analgesic request postoperatively with reduced perioperative analgesia consumption, without significant side effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joacp.joacp_14_24","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T08:01:36Z","timestamp":1719561696000},"page":"333-339","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Postoperative analgesic effect of adding neostigmine to levobupivacaine in ultrasound-guided spermatic cord block for testicular sperm extraction surgery"],"prefix":"10.4103","volume":"41","author":[{"given":"Amr Samir","family":"Wahdan","sequence":"first","affiliation":[{"name":"Department of Anesthesia, Surgical ICU and Pain Management, Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Abdelhady","family":"Moussa","sequence":"additional","affiliation":[{"name":"Department of Andrology, Sexology and STDS, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Abdel Fattah","family":"Farag","sequence":"additional","affiliation":[{"name":"Department of Andrology, Sexology and STDS, Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Abdullah","family":"Alayyaf","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Pain Management, Al-Hada Armed Forces Hospital, Taif, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mennatallah Magdi","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Surgical ICU and Pain Management, Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"R1-20250324","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1093\/HUMREP\/10.6.1457","article-title":"Pregnancies after testicular sperm extraction and intracytoplasmic sperm injection in non-obstructive azoospermia","volume":"10","author":"Devroey","year":"1995","journal-title":"Hum Reprod"},{"key":"R2-20250324","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4111\/kju.2015.56.1.3","article-title":"Scrotal pain: Evaluation and 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