{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:01:40Z","timestamp":1787169700690,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"\n Background and Aims:<\/jats:title>\n \n Propofol is a commonly used sedative agent, in a dose of 1.5\u20134.5 mg.kg\n \u20131<\/jats:sup>\n .h\n \u20131<\/jats:sup>\n . Following liver transplantation (LT), drug metabolism may be altered due to liver mass, altered hepatic blood flow, reduced levels of serum proteins, and liver regeneration. Thus, we hypothesized that propofol requirements in this group of patients would be different as compared to the standard dose. This study evaluated the dose of propofol used for sedation in electively ventilated living donor liver transplantation (LDLT) recipients.\n <\/jats:p>\n <\/jats:sec>\n \n Material and Methods:<\/jats:title>\n \n After patients were shifted to the postoperative intensive care unit (ICU) following LDLT surgery, propofol infusion was started at a dose of 1 mg.kg\n \u20131<\/jats:sup>\n .h\n \u20131<\/jats:sup>\n and titrated to maintain a bispectral index (BIS) value of 60\u201380. No other sedatives such as opioids or benzodiazepines were used. Dose of propofol, noradrenaline, and arterial lactate levels were noted 2 hourly.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The mean propofol dose required in these patients was 1.02 \u00b1 0.26 mg.kg\n \u20131<\/jats:sup>\n .h\n \u20131<\/jats:sup>\n . Noradrenaline was gradually tapered off and stopped within 14 h of shifting to ICU. The mean duration between the time of cessation of propofol infusion till extubation was 2.06 \u00b1 1.44 h. Propofol dose did not correlate with respective lactate levels, ammonia levels, or graft-to-recipient weight ratio.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The dose range of propofol required for postoperative sedation in LDLT recipients was lower than the conventional dose.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/joacp.joacp_169_21","type":"journal-article","created":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T05:45:40Z","timestamp":1679204740000},"page":"84-87","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Low-dose propofol as a solo agent for sedation in postoperative ventilated liver transplant recipients: A preliminary observational study"],"prefix":"10.4103","volume":"39","author":[{"given":"Rishabh","family":"Jaju","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Critical Care, All India Institute of Medical Sciences, Deoghar, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelika","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Critical Care, AIIMS, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. K.","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Critical Care, Institute of Liver and Biliary Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"R1-20240828","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jhep.2010.06.023","article-title":"Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam:A randomized controlled study","volume":"54","author":"Khamaysi","year":"2011","journal-title":"J Hepatol"},{"key":"R2-20240828","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1385\/NCC:4:2:179","article-title":"Therapy of intracranial hypertension in patients with fulminant hepatic failure","volume":"4","author":"Raghavan","year":"2006","journal-title":"Neurocrit Care"},{"key":"R3-20240828","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jcrc.2016.10.026","article-title":"Dexmedetomidine vs propofol sedation reduces delirium in patient after cardiac surgery:A meta-analysis with trial sequential analysis of randomized controlled trials","volume":"38","author":"Liu","year":"2017","journal-title":"J Crit Care"},{"key":"R4-20240828","first-page":"231","article-title":"Effects of dexmedetomidine and propofol on sedation in patients after coronary artery bypass graft surgery in a fasttrack recovery room setting","volume":"12","author":"Karaman","year":"2015","journal-title":"J Anesth"},{"key":"R5-20240828","first-page":"153","article-title":"Dexmedetomidine vs. Propofol for short-term sedation of postoperative mechanically ventilated patients","volume":"16","author":"Elbaradie","year":"2004","journal-title":"J Egypt Natl Cancer Inst"},{"key":"R6-20240828","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/bja\/87.5.684","article-title":"Comparision between dexmedetomidine and propofol for sedation in the intensive care unit:Patient and clinical perceptions","volume":"87","author":"Venn","year":"2001","journal-title":"Br J Anaesth"},{"key":"R8-20240828","first-page":"e17109","article-title":"Sedative efficacy of propofol in patients intubated\/ventilated after coronary artery bypass graft surgery","volume":"4","author":"Aghdaii","year":"2014","journal-title":"Anesth Pain Med"},{"key":"R9-20240828","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1517\/17425255.2016.1139575","article-title":"Pharmacokinetics of drugs in adult living donor liver transplant patients:Regulatory factors and observations based on studies in animals and humans","volume":"12","author":"Li","year":"2016","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"R10-20240828","doi-asserted-by":"crossref","DOI":"10.4172\/2167-0889.1000115","article-title":"ASS and SULT2A1 are novel and sensitive biomarkers of acute hepatic injury- a comparative study in animal models","volume":"2","author":"Prima","year":"2013","journal-title":"J Liver"},{"key":"R11-20240828","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2165\/00044011-199509010-00003","article-title":"Clinical pharmacokinetics of propofol in postoperative sedation after orthotopic liver transplantation","volume":"9","author":"Debruyne","year":"1995","journal-title":"Clin Drug Invest"},{"key":"R12-20240828","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0891-5849(95)00024-R","article-title":"Oxidative damage in human liver transplantation","volume":"19","author":"Biasi","year":"1995","journal-title":"Free Radic Biol Med"}],"container-title":["Journal of Anaesthesiology Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/joacp.joacp_169_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:11:07Z","timestamp":1787166667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/joacp.joacp_169_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,3]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/joacp.joacp_169_21","relation":{},"ISSN":["0970-9185","2231-2730"],"issn-type":[{"value":"0970-9185","type":"print"},{"value":"2231-2730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,3]]},"assertion":[{"value":"2021-04-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}