{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:01:24Z","timestamp":1787169684447,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>Caudal epidural and ultrasound-guided ilioinguinal, iliohypogastric nerve (IL\/IH) blocks are commonly used regional anesthesia techniques for postoperative analgesia in pediatric inguinal surgeries. Dexmedetomidine as an adjuvant has been proven to prolong the duration of both neuraxial and peripheral nerve blocks. We compared the duration of analgesia provided by local anesthetic (LA) and dexmedetomidine for caudal and IL\/IH block for pediatric inguinal surgeries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>\n                      Forty-six children undergoing inguinal hernia repair were selected for this randomized double-blind study. After general anesthesia, children received either 0.75 mL.kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      of 0.25% bupivacaine with 1 mcg.kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      of dexmedetomidine in caudal epidural or 0.25 mL.kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      of 0.25% bupivacaine with 1 mcg.kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      of dexmedetomidine in IL\/IH block. The pain was assessed up to 24 h postoperatively using face, legs, activity, cry, consolability (FLACC) score. For FLACC \u22654, rescue analgesia was provided using 1 \u03bcg\/kg of intravenous fentanyl, up to 2 h postoperatively and 10 mg\/kg of oral ibuprofen between 2 and 24 postoperative hours. The time for first rescue analgesia was taken as the duration of analgesia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were no significant differences in the pain scores or analgesic utilization between the groups. The duration of analgesia of caudal and IL\/IH blocks was similar (720.3 \u00b1 430.1 min and 808.4 \u00b1 453.1 min, respectively). The time taken for the performance of block was significantly higher for caudal compared to IL\/IH (547 \u00b1 93 vs. 317 \u00b1 179 s;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Both caudal epidural and USG-IL\/IH block with dexmedetomidine as additive provide the comparable duration of postoperative analgesia with no significant side effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joacp.joacp_175_19","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T05:47:11Z","timestamp":1635227231000},"page":"389-394","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["Comparison between caudal epidural and ultrasound-guided ilioinguinal-iliohypogastric block with bupivacaine and dexmedetomidine for postoperative analgesia following pediatric inguinal hernia surgeries: A prospective randomized, double-blind study"],"prefix":"10.4103","volume":"37","author":[{"given":"R","family":"Varsha","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, SDM College of Medical Sciences and Hospital, Dharawd, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer N.","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, SDM College of Medical Sciences and Hospital, Dharawd, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahantesh S.","family":"Mudakanagoudar","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, SDM College of Medical Sciences and Hospital, Dharawd, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesh M.","family":"Annigeri","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, SDM College of Medical Sciences and Hospital, Dharawd, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"-20240828","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/bja\/64.1.85","article-title":"Pain management in paediatric patients","volume":"64","author":"Lloyd-Thomas","year":"1990","journal-title":"Br J Anaesth"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1111\/j.1365-2044.1986.tb12956.x","article-title":"Ilioinguinal nerve block in children. A comparison with caudal block for intra and postoperative analgesia","volume":"41","author":"Markham","year":"1986","journal-title":"Anaesthesia"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/bja\/aei157","article-title":"Ultrasonography for ilioinguinal\/iliohypogastric nerve blocks in children","volume":"95","author":"Willschke","year":"2005","journal-title":"Br J Anaesth"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s12871-020-01170-z","article-title":"Ultrasound-guided ilioinguinal-iliohypogastric block (ILIHB) or perifocal wound infiltration (PWI) in children: a prospective randomized comparison of analgesia quality, a pilot study","volume":"20","author":"Grosse","year":"2020","journal-title":"BMC Anesthesiol"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1589\/jpts.28.1055","article-title":"Improved perioperative analgesia with ultrasound-guided ilioinguinal\/iliohypogastric nerve or transversus abdominis plane block for open inguinal surgery: a systematic review and meta-analysis of randomized controlled trials","volume":"28","author":"Wang","year":"2016","journal-title":"J Phys Ther Sci"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"367","DOI":"10.4103\/1658-354X.105868","article-title":"Ultrasound-guided ilioinguinal\/iliohypogastric nerve blocks versus caudal block for postoperative analgesia in children undergoing unilateral groin surgery","volume":"6","author":"Abdellatif","year":"2012","journal-title":"Saudi J Anaesth"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4103\/sja.SJA_423_19","article-title":"Review of adjuvants to local anesthetics in peripheral nerve blocks: Current and future trends","volume":"14","author":"Krishna Prasad","year":"2020","journal-title":"Saudi J Anaesth"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"409","DOI":"10.4103\/0019-5049.183394","article-title":"Comparison between two doses of dexmedetomidine added to bupivacaine for caudal analgesia in paediatric infraumbilical surgeries","volume":"60","author":"Meenakshi Karuppiah","year":"2016","journal-title":"Indian J Anaesth"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/ALN.0b013e318182c26b","article-title":"Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat","volume":"109","author":"Brummett","year":"2008","journal-title":"Anesthesiology"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"924","DOI":"10.4103\/aer.AER_169_18","article-title":"Effect of Dexmedetomidine as an Adjuvant to Ropivacaine in Ilioinguinal-Iliohypogastric Nerve Blocks for Inguinal Hernia Repair in Pediatric Patients: A Randomized, Double-Blind, Control Trial","volume":"12","author":"Karan","year":"2018","journal-title":"Anesth Essays Res"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/pan.12704","article-title":"Dexmedetomidine as adjunct to ilioinguinal\/iliohypogastric nerve blocks for paediatric inguinal hernia repair: An exploratory randomised controlled trial","volume":"25","author":"Lundblad","year":"2015","journal-title":"Paediatr Anaesth"},{"key":"-20240828","first-page":"293","article-title":"The FLACC: A behavioral scale for scoring postoperative pain in young children","volume":"23","author":"Merkel","year":"1997","journal-title":"Pediatric Nursing"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/pan.12686","article-title":"Comparison of caudal bupivacaine alone with bupivacaine plus two doses of dexmedetomidine for postoperative analgesia in paediatric patients undergoing infra-umbilical surgery: A randomised controlled double-blinded study","volume":"25","author":"Al Zaben","year":"2015","journal-title":"Paediatr Anaesth"},{"key":"-20240828","first-page":"115","article-title":"Ultrasound guided nerve block versus caudal block for post-operative analgesia in children undergoing unilateral groin surgery","volume":"3","author":"Ravi","year":"2016","journal-title":"Int Arch Integr Med"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/bja\/aep159","article-title":"Addition of clonidine or dexmedetomidine to bupivacaine prolongs caudal analgesia in children","volume":"103","author":"El-Hennawy","year":"2009","journal-title":"Br J Anaesth"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4103\/0259-1162.174468","article-title":"Dexmedetomidine as an adjuvant to bupivacaine in caudal analgesia in children","volume":"10","author":"Goyal","year":"2016","journal-title":"Anesth Essays Res"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4103\/0019-5049.84835","article-title":"Effects of dexmedetomidine added to caudal ropivacaine in paediatric lower abdominal surgeries","volume":"55","author":"Anand","year":"2011","journal-title":"Indian J Anaesth"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1399-6576.2008.01818.x","article-title":"Effect of dexmedetomidine on the characteristics of bupivacaine in a caudal block in pediatrics","volume":"53","author":"Saadawy","year":"2009","journal-title":"Acta Anaesthesiol Scand"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.egja.2012.10.005","article-title":"Efficacy of dexmedetomidine addition to bupivacaine on the quality of blind fascia iliaca compartment block in children undergoing femur fracture surgery","volume":"29","author":"El-Rahmawy","year":"2013","journal-title":"Egypt J Anaesth"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/EJA.0b013e3283347c15","article-title":"Addition of dexmedetomidine to bupivacaine for greater palatine nerve block prolongs postoperative analgesia after cleft palate repair","volume":"27","author":"Gihan","year":"2010","journal-title":"European J Anaeth"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/pan.12825","article-title":"Alpha- 2 adreno receptor agonists as adjuncts to peripheral nerve blocks in children: A meta-analysis","volume":"26","author":"Lundblad","year":"2016","journal-title":"Paediatr Anaesth"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/bja\/aet066","article-title":"Facilitatory effects of perineural dexmedetomidine on neuraxial and peripheral nerve block: A systematic review and meta-analysis","volume":"110","author":"Abdallah","year":"2013","journal-title":"Br J Anaesth"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1093\/bja\/aes400","article-title":"Dexmedetomidine as an adjuvant to ropivacaine prolongs peripheral nerve block: A volunteer study","volume":"110","author":"Marhofer","year":"2013","journal-title":"Br J Anaesth"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/ALN.0000000000001429","article-title":"Does dexmedetomidine have a perineural mechanism of action when used as an adjuvant to ropivacaine?: A paired, blinded, randomized trial in healthy volunteers","volume":"126","author":"Andersen","year":"2017","journal-title":"Anesthesiology"},{"key":"-20240828","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/ALN.0000000000000983","article-title":"IV and perineural dexmedetomidine similarly prolong the duration of analgesia after interscalene brachial plexus block: A randomized, three-arm, triple-masked, placebo-controlled trial","volume":"124","author":"Abdallah","year":"2016","journal-title":"Anesthesiology"}],"container-title":["Journal of Anaesthesiology Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/joacp.JOACP_175_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:10:41Z","timestamp":1787166641000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/joacp.JOACP_175_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/joacp.joacp_175_19","relation":{},"ISSN":["2231-2730","0970-9185"],"issn-type":[{"value":"2231-2730","type":"print"},{"value":"0970-9185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"2019-06-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}