{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:20:39Z","timestamp":1787772039755,"version":"build-2784847793"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aims:<\/jats:title>\n \n Magnesium sulfate (MgSO\n 4<\/jats:sub>\n ) has been demonstrated to have analgesic property in various clinical settings. This study explores if addition of MgSO\n 4<\/jats:sub>\n to ropivacaine increases its analgesic efficacy when infiltrated continuously in the postsurgical wound following total abdominal hysterectomy.\n <\/jats:p>\n <\/jats:sec>\n \n Material and Methods:<\/jats:title>\n \n This randomized controlled trial was conducted at a tertiary care referral hospital in New Delhi, India. Fifty-two patients were randomized into two groups to receive the intervention of which 48 were able to complete the study. The first group (\n n<\/jats:italic>\n = 26) received 0.25% ropivacaine infiltration and the second group (\n n<\/jats:italic>\n = 26) received 0.25% ropivacaine with 5% MgSO\n 4<\/jats:sub>\n at the incision site for 48 h postoperatively. Primary objective was to compare the total postoperative opioid (morphine) consumption by the study participants in both the groups and the secondary objectives were pain scores at rest and at movement, patient satisfaction score, and wound quality of life on the 7\n th<\/jats:sup>\n postoperative day among the two groups.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Both the groups were comparable in their demographic characteristics. The median morphine consumed at 48 h postoperatively was 16.5 [0\u201377] mg in the ropivacaine group and 13[1\u201345] mg in the ropivacaine with MgSO\n 4<\/jats:sub>\n group and the difference was statistically insignificant (\n P<\/jats:italic>\n = 0.788). There was no statistical difference between the groups with respect to the pain scores, patient satisfaction, or wound quality of life at 7 days.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n The addition of MgSO\n 4<\/jats:sub>\n to ropivacaine does not confer any additional postoperative analgesic benefits over ropivacaine alone in continuous wound infiltration following total abdominal hysterectomy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/joacp.joacp_239_22","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T15:01:13Z","timestamp":1710428473000},"page":"140-146","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["To assess the analgesic efficacy of adjuvant magnesium sulfate added with ropivacaine over ropivacaine alone as a continuous infiltration in total abdominal hysterectomy wound: A randomized controlled trial"],"prefix":"10.4103","volume":"40","author":[{"given":"Devalina","family":"Goswami","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine and Critical Care, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh K.","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine and Critical Care, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik V.","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine and Critical Care, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nageswara Rao","family":"Tangirala","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine and Critical Care, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai Bhagwan","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mani","family":"Kalaivani","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"R1-20240828","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1002\/bjs.9204","article-title":"Systematic review and meta-analysis of continuous local anaesthetic wound infiltration versus epidural analgesia 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