{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:33:46Z","timestamp":1787841226180,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>Ondansetron and dexamethasone combination is effective for prophylaxis against postoperative nausea and vomiting (PONV). Ondansetron, when compared to dexamethasone, is known to cause more adverse effects and is relatively expensive. The present study evaluated the efficacy of standard dose and low dose ondansetron, i.e. 100 \u03bcg\/kg and 50 \u03bcg\/kg, respectively, with dexamethasone 8 mg for PONV prophylaxis in laparoscopic cholecystectomy (LC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>After the approval from the Institutional Ethics Committee-Human Research [IEC-HR] and prospective CTRI registration, this randomized, double-blind interventional study was conducted following informed consent from each participant. Patients aged 18\u201365 years of either sex, with ASA physical status I or II, undergoing LC under general anesthesia, were included and divided into groups C and L. Patients in groups C and L received 100 \u03bcg and 50 \u03bcg of ondansetron, respectively, in combination with 8 mg dexamethasone. The incidence of PONV in first 6 hrs, PONV score, rescue antiemetic consumption, rescue analgesia, and hemodynamic parameters were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 110 patients were included with 55 in each group. Incidence of PONV in the first 6 hours was found to be higher in 1\u20132 hour- and 2\u20133-hour time intervals in group L; but was significant only at 1\u20132-hour time interval (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Proportion of patients needing rescue antiemetic in the first 6 hours was higher in group L but was not statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We observed that 50 \u03bcg\/kg combination of ondansetron was associated with higher incidence of post operative nausea in the immediate postoperative period than 100 \u03bcg\/kg dose; however, no significant difference was observed in incidence of post-operative vomiting between two doses following LC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joacp.joacp_357_23","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T05:01:03Z","timestamp":1734325263000},"page":"84-89","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Low dose ondansetron with dexamethasone for prophylaxis of postoperative nausea and vomiting following laparoscopic cholecystectomy\u2014A randomized double-blind study"],"prefix":"10.4103","volume":"41","author":[{"given":"Geetanjali T","family":"Chilkoti","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Shahdara, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janaki","family":"Nandanan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Shahdara, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Shahdara, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Seth","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Shahdara, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navneet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, Shahdara, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakriti","family":"Maurya","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Shahdara, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"R1-20250122","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1213\/ANE.0000000000000002","article-title":"Consensus guidelines for the management of postoperative nausea and vomiting","volume":"118","author":"Gan","year":"2014","journal-title":"Anesth Analg"},{"key":"R2-20250122","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1365-2044.1996.tb07654.x","article-title":"Antiemetic efficacy of prophylactic ondansetron in laparoscopic cholecystectomy. 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