{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:28:08Z","timestamp":1786739288149,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>There has been tremendous growth in patients requiring critical care with severe infections. During a prolonged stay in the intensive care unit (ICU), patients develop critical illness polyneuropathy (CIP). The early identification of neurological involvement requires special attention during ICU care. We describe two cases who developed complete motor weakness after a prolonged stay in ICU. Patients were successfully managed with pyridostigmine and testosterone hormonal therapy initially and later with pyridostigmine only. The present case series highlights the need for early recognition, assessment, and novel management of CIP in ICU patients. However, the role of nutrition, physiotherapy, and supportive care is equally essential for the successful outcome in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joacp.joacp_427_19","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T14:48:45Z","timestamp":1626360525000},"page":"290-292","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Novel management of critically induced polyneuropathy in intensive care patients"],"prefix":"10.4103","volume":"37","author":[{"given":"Vanita","family":"Ahuja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selwin Rajan","family":"Selvam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjuman","family":"Chander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishit","family":"Sawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-24-20240828","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1378\/chest.99.1.176","article-title":"Peripheral nerve function in sepsis and multiple organ failure","volume":"99","author":"Witt","year":"1991","journal-title":"Chest"},{"key":"R3-24-20240828","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1007\/s001340000586","article-title":"Early signs of critical illness polyneuropathy in ICU patients with systemic inflammatory response syndrome or sepsis","volume":"26","author":"Tennil\u00e4","year":"2000","journal-title":"Intensive Care Med"},{"key":"R4-24-20240828","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1001\/jama.288.22.2859","article-title":"Paresis acquired in the intensive care unit: A prospective multicenter study","volume":"288","author":"De Jonghe","year":"2002","journal-title":"JAMA"},{"key":"R5-24-20240828","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s001340050669","article-title":"Patterns of neurophysiological abnormality in prolonged critical illness","volume":"24","author":"Coakley","year":"1998","journal-title":"Intensive Care Med"},{"key":"R6-24-20240828","first-page":"CD006832","article-title":"Interventions for preventing critical illness polyneuropathy and critical illness myopathy (Protocol)","volume":"1","author":"Hermans","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"R7-24-20240828","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/ane.12964","article-title":"Risk factors for intensive care unit-acquired weakness: A systematic review and meta-analysis","volume":"138","author":"Yang","year":"2018","journal-title":"Acta Neurol Scand"},{"key":"R8-24-20240828","first-page":"CD006832","article-title":"Interventions for preventing critical illness polyneuropathy and critical illness myopathy","volume":"1","author":"Hermans","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"R9-24-20240828","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/physrev.00028.2014","article-title":"The sick and the weak: Neuropathies\/myopathies in the critically ill","volume":"95","author":"Friedrich","year":"2015","journal-title":"Physiol Rev"},{"key":"R10-24-20240828","first-page":"4545623","article-title":"Anabolic steroid use for weight and strength gain in critically ill patients: A case series and review of the literature","volume":"2018","author":"Anstey","year":"2018","journal-title":"Case Rep Crit Care"},{"key":"R11-24-20240828","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/08880010701451327","article-title":"Pyridoxine and pyridostigmine treatment in vincristine-induced neuropathy","volume":"24","author":"Ozyurek","year":"2007","journal-title":"Pediatr Hematol Oncol"}],"container-title":["Journal of Anaesthesiology Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/joacp.JOACP_427_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:27:36Z","timestamp":1786735656000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/joacp.JOACP_427_19"}},"subtitle":["A case report of two patients"],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/joacp.joacp_427_19","relation":{},"ISSN":["0970-9185"],"issn-type":[{"value":"0970-9185","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}