{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:22:36Z","timestamp":1787757756382,"version":"build-2784847793"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    A systematic electronic search of MEDLINE, EMBASE, and CINAHL databases aimed at comparing neurokinin-1 receptor antagonists with other antiemetics in their prevention of postoperative nausea and vomiting in adult patients undergoing laparoscopic surgery identified seven randomized controlled trials for review and meta-analysis. Preoperative aprepitant 80 mg was found to reduce nausea (RR: 0.56, 95% CI: 0.41\u20130.75, I\n                    <jats:sup>2<\/jats:sup>\n                    = 0%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.89) and vomiting (RR: 0.20, 95% CI: 0.05\u20130.77, I\n                    <jats:sup>2<\/jats:sup>\n                    = 0%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.96) and resulted in complete response (RR: 1.61 (1.25-2.08), I\n                    <jats:sup>2<\/jats:sup>\n                    = 0%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.70) within the first 2 hours following surgery as well as vomiting in 2\u201324 hours (RR: 0.09, 95% CI: 0.02-0.36, I\n                    <jats:sup>2<\/jats:sup>\n                    = 0%;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.81) when compared to placebo or no antiemetic therapy. Preoperative aprepitant 80 mg has a superior overall effect compared to placebo or other antiemetics in the first two hours postoperatively, and thereafter reduces the risk of vomiting alone in the first 24 hours following laparoscopic surgeries.\n                  <\/jats:p>","DOI":"10.4103\/joacp.joacp_464_20","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T08:45:56Z","timestamp":1651221956000},"page":"35-47","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["NK1 receptor antagonists versus other antiemetics in the prevention of postoperative nausea and vomiting following laparoscopic surgical procedures: a systematic review and meta-analysis"],"prefix":"10.4103","volume":"38","author":[{"given":"John","family":"Cavaye","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Queensland, Queensland, Australia"},{"name":"Department of Anaesthesia and 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