{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:31:14Z","timestamp":1787758274860,"version":"build-2784847793"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>Hypotension following subarachnoid block for cesarean delivery (CD) is common. We compared the effect of bolus administration of norepinephrine and phenylephrine on umbilical artery pH (primary objective) and their efficacy for the treatment of maternal hypotension (secondary objective) in term parturients undergoing elective CD under spinal anesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>\n                      In a randomized, double-blinded study, parturients received 1 mL boluses of either phenylephrine 100 \u03bcg\/mL (group phenylephrine;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 45) or norepinephrine 7.5 \u03bcg\/mL (group norepinephrine;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 45) whenever maternal systolic blood pressure decreased to \u226480% of baseline. Maternal hemodynamic changes, vasopressor, and atropine requirement and neonatal outcome (umbilical cord blood gas analysis, Apgar scores, neonatal neurobehavioral response) were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The Apgar scores and umbilical cord blood gas analysis were comparable between groups. The neurobehavioral scale score was significantly higher in group NE compared with that in group PE at 24 h and 48 h;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007 and 0.002, respectively. The number of vasopressor doses and time to the first vasopressor requirement for maintaining systolic pressure &gt;80% of baseline was comparable in both groups. Incidence of bradycardia (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.009), reactive hypertension (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003), and dose requirement of atropine (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.005) was higher in group PE compared with group NE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In term normotensive parturients who received bolus norepinephrine 7.5 \u03bcg or phenylephrine 100 \u03bcg for the treatment of post-spinal hypotension during CD, neonatal umbilical cord blood gas analysis and Apgar scores were comparable. Norepinephrine use was associated with a lower incidence of maternal bradycardia and reactive hypertension compared with phenylephrine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joacp.joacp_499_20","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T11:28:33Z","timestamp":1665487713000},"page":"445-452","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of phenylephrine and norepinephrine for treatment of spinal hypotension during elective cesarean delivery- A randomised, double-blind study"],"prefix":"10.4103","volume":"38","author":[{"given":"Akshatha V.","family":"Rai","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, 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