{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:06:43Z","timestamp":1787170003673,"version":"build-2736575974"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim:<\/jats:title>\n                    <jats:p>Pneumoperitoneum (PP) and the Trendelenburg position (TP) in laparoscopic surgeries are associated with rise in intracranial pressure (ICP). The optic nerve sheath diameter (ONSD) is a surrogate marker of ICP. The study aimed to evaluate the effect of sevoflurane, propofol and propofol with dexmedetomidine as maintenance agent on ICP in TP during laparoscopic surgeries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 120 American Society of Anesthesiologists (ASA) physical status I\/II patients, aged 18\u201365 years were randomly allocated into three groups: sevoflurane as group S, propofol as group P, and propofol with dexmedetomidine as group PD. The intra-abdominal pressure (IAP) was kept in the range of 12\u201314 mmHg and TP varied between 15\u00b0\u2013 45\u00b0 angle. The primary objective was comparison of ICP and secondary objectives were IOP, intraoperative hemodynamic and postoperative recovery characteristics among groups. The ONSD and IOP were measured in both eyes 10 min after endotracheal intubation (T0), 5 min after CO\n                      <jats:sub>2<\/jats:sub>\n                      insufflation (T1), 5 min after TP (T2) and 5 min after deflation of gas (T3). The data were analyzed by using the Statistical Package for Social Sciences version 23.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>ONSD and IOP at T1 and T2 were significantly higher than T0 in all groups, but no significant difference was found among the intergroup groups. Significantly lower heart rate and mean blood pressure were observed in PD group at T1 and T2 compared to group S and group P.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The rise in ICP was comparable among sevoflurane, propofol, and propofol\u2013dexmedetomidine combination as a maintenance agent during laparoscopic surgeries in TP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/joacp.joacp_511_21","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T12:14:55Z","timestamp":1695989695000},"page":"474-481","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Effect of sevoflurane, propofol and propofol with dexmedetomidine as maintenance agent on intracranial pressure in the Trendelenburg position during laparoscopic surgeries"],"prefix":"10.4103","volume":"39","author":[{"given":"Manoj","family":"Kamal","sequence":"first","affiliation":[{"name":"Anaesthesiology and Critical Care, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev Kumar","family":"Chawriya","sequence":"additional","affiliation":[{"name":"Anaesthesiology and Critical Care, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mritunjay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Anaesthesiology, Critical Care and Pain Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narendra","family":"Kaloria","sequence":"additional","affiliation":[{"name":"Anaesthesiology and Critical Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur","family":"Sharma","sequence":"additional","affiliation":[{"name":"Anaesthesiology and Critical Care, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Anaesthesiology and Critical Care, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geeta","family":"Singariya","sequence":"additional","affiliation":[{"name":"Department Anaesthesiology and Critical Care, Dr. S N Medical College, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Paliwal","sequence":"additional","affiliation":[{"name":"Anaesthesiology and Critical Care, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"R1-20240828","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.jpedsurg.2016.05.006","article-title":"Laparoscopic pyloromyotomy decreases postoperative length of stay in children with hypertrophic pyloric stenosis","volume":"51","author":"Mahida","year":"2016","journal-title":"J Pediatr Surg"},{"key":"R2-20240828","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/00003246-199703000-00020","article-title":"A proposed relationship between increased intra-abdominal, intrathoracic, and intracranial pressure","volume":"25","author":"Bloomfield","year":"1997","journal-title":"Crit Care Med"},{"key":"R3-20240828","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3171\/jns.1997.87.1.0034","article-title":"Validation of the optic nerve sheath response to changing cerebrospinal fluid pressure:Ultrasound findings during intrathecal infusion tests","volume":"87","author":"Hansen","year":"1997","journal-title":"J Neurosurg"},{"key":"R4-20240828","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00464-017-5653-3","article-title":"Ultrasonographic optic nerve sheath diameter for predicting elevated intracranial pressure during laparoscopic surgery. 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