{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:30:18Z","timestamp":1787761818927,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aims:<\/jats:title>\n Pre-eclamptic parturients may have an exaggerated response to vasopressors. This study compares the efficacy of a 50 \u03bcg fixed bolus of phenylephrine for treatment of post-spinal hypotension in pre-eclamptic versus normotensive parturients.<\/jats:p>\n <\/jats:sec>\n \n Material and Methods:<\/jats:title>\n \n After written informed consent and ethics committee approval, 30 normotensive and 30 pre-eclamptic parturients between 18 and 40 years with singleton term pregnancy about to undergo cesarean section (CS) under spinal anesthesia were included. Post-spinal hypotension was treated with a 50 \u03bcg fixed bolus of phenylephrine. The cumulative dose of phenylephrine, the number of boluses, and the median dose required to treat the first hypotensive episode, total number of hypotensive episodes, maternal side effects, neonatal appearance, pulse, grimace, activity, and respiration (APGAR) scores, and umbilical arterial cord blood pH were noted. Statistical analysis was done using Student\u2019s t-test, Mann\u2013Whitney U-test, Chi-square test\/Fisher\u2019s exact test as appropriate. A\n P<\/jats:italic>\n <0.05 was considered significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The cumulative dose and number of boluses of phenylephrine required to treat post-spinal hypotension were comparable. The median dose required to treat the first episode of post-spinal hypotension was also similar (\n p<\/jats:italic>\n = 0.792). The time to develop the first hypotensive episode was significantly earlier for group N (\n p<\/jats:italic>\n = 0.002). The efficacy of a single fixed bolus of 50 \u03bcg phenylephrine was similar in both groups (\n p<\/jats:italic>\n = 1.000). Neonatal median APGAR scores at 1 min after birth were significantly higher for group N (\n p<\/jats:italic>\n = 0.016).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n A fixed-dose bolus of 50 \u03bcg phenylephrine is safe and effective in treating post-spinal hypotension in pre-eclampsia. The efficacy of phenylephrine is comparable in pre-eclamptic and normotensive parturients.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/joacp.joacp_518_21","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T22:00:59Z","timestamp":1683842459000},"page":"451-457","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of fixed-dose phenylephrine bolus for treating post-spinal hypotension: Comparison between pre-eclamptics and normotensives"],"prefix":"10.4103","volume":"39","author":[{"given":"Rashmi","family":"Salhotra","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care, UCMS and GTB Hospital, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, UCMS and GTB Hospital, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh Singh","family":"Rautela","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, UCMS and GTB Hospital, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jainendra","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, UCMS and GTB Hospital, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lhamo","family":"Dolma","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Sikkim Manipal Institute of Medical Sciences, Central Referral Hospital, Gangtok, Sikkim, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Department of Onco-Anesthesia and Palliative Medicine, Dr. BRAIRCH, 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