{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:31:59Z","timestamp":1786739519208,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,7]]},"abstract":"\n Background and Aims:<\/jats:title>\n \n Acute kidney injury (AKI) following cardiac surgery is a major complication resulting in increased morbidity, mortality and economic burden. This study was designed to determine the benefit of sodium bicarbonate (NaHCO\n 3<\/jats:sub>\n ) supplementation in patients with stable chronic kidney disease (CKD) undergoing off-pump coronary artery bypass grafting (OP-CABG).\n <\/jats:p>\n <\/jats:sec>\n \n Material and Methods:<\/jats:title>\n \n We prospectively studied 60 non-dialysis CKD patients with glomerular filtration rate (GFR) \u226460 ml\/min\/1.73 m\n 2<\/jats:sup>\n requiring elective OP-CABG. They were randomly allocatted to one of the two groups. One group received NaHCO\n 3<\/jats:sub>\n infusion at 0.5 mmol\/kg first hour followed by 0.2 mmol\/kg\/h till the end of surgery and the other group received 0.9% NaCl. A third group of 30 patients without renal dysfunction undergoing OP-CABG was included. The serum creatinine was estimated prior to surgery, immediately after surgery and on postoperative days 1, 2, 3 and 4.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Ten patients (33.3%) in NaCl and 6 (20%) patients each in NaHCO\n 3<\/jats:sub>\n and normal groups developed Stage-1 AKI. None of our study patient required renal replacement therapy and no mortality was observed in any of the groups during the perioperative and hospitalization period.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Perioperative infusion of NaHCO\n 3<\/jats:sub>\n in OP-CABG reduced the incidence of Stage-1 AKI by about 40% when compared to NaCl. The incidence of Stage-I AKI in NaHCO\n 3<\/jats:sub>\n group was similar to that in patients with normal renal function undergoing OP-CABG. A larger group of patients may be required to suggest a significance of renal protective benefit of NaHCO\n 3<\/jats:sub>\n in patients undergoing OP-CABG.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/joacp.joacp_75_18","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T10:44:16Z","timestamp":1645699456000},"page":"301-306","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Effect of sodium bicarbonate infusion in off-pump coronary artery bypass grafting in patients with renal dysfunction"],"prefix":"10.4103","volume":"34","author":[{"given":"Muralidhar","family":"Kanchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudresh","family":"Manjunath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos","family":"Maessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Belani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20260203","doi-asserted-by":"crossref","first-page":"194","DOI":"10.7326\/0003-4819-128-3-199802010-00005","article-title":"Renal dysfunction after myocardial revascularization: Risk factors, adverse outcomes, and hospital resource utilization. The Multicenter Study of Perioperative Ischemia Research Group","volume":"128","author":"Mangano","year":"1998","journal-title":"Ann Intern Med"},{"key":"R4-4-20260203","doi-asserted-by":"crossref","first-page":"e3720","DOI":"10.1097\/MD.0000000000003720","article-title":"Sodium bicarbonate prevents contrast-induced nephropathy in addition to theophylline: A randomized controlled trial","volume":"95","author":"Huber","year":"2016","journal-title":"Medicine (Baltimore"},{"key":"R5-4-20260203","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1148\/radiology.175.1.2315505","article-title":"Oxygen free radical involvement in urinary Tamm-Horsfall protein excretion after intrarenal injection of contrast medium","volume":"175","author":"Bakris","year":"1990","journal-title":"Radiology"},{"key":"R6-4-20260203","first-page":"F115","article-title":"Radiocontrast medium-induced declines in renal function: A role for oxygen free 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after cardiac surgery: A pilot double-blind, randomized controlled trial","volume":"37","author":"Haase","year":"2009","journal-title":"Crit Care Med"},{"key":"R13-4-20260203","doi-asserted-by":"crossref","first-page":"e1001426","DOI":"10.1371\/journal.pmed.1001426","article-title":"Prophylactic perioperative sodium bicarbonate to prevent acute kidney injury following open heart surgery: A multicenter double-blinded randomized controlled trial","volume":"10","author":"Haase","year":"2013","journal-title":"PLoS Med"},{"key":"R14-4-20260203","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1097\/CCM.0b013e31828a3f99","article-title":"Sodium bicarbonate infusion to reduce cardiac surgery-associated acute kidney injury: A phase II multicenter double-blind randomized controlled trial","volume":"41","author":"McGuinness","year":"2013","journal-title":"Crit Care 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