{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:38:48Z","timestamp":1787071128439,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aims:<\/jats:title>\n Bone and soft tissue (BST) cancer surgeries of extremities and pelvis have a high incidence of postoperative neuropathic pain (NP) due to extensive soft tissue dissection and breach of internervous planes. The primary aim of this study is to assess the incidence of NP in patients undergoing BST tumor surgery and establish its predisposing factors.<\/jats:p>\n <\/jats:sec>\n \n Material and Methods:<\/jats:title>\n This prospective observational study assessed the incidence of NP after BST surgery at a tertiary care cancer center from April 2021 to June 2022. Postoperatively, NP follow-up was done with PainDETECT Questionnaire (PD-Q). Pain severity was assessed with Numerical Rating Scale, and Brief Pain Inventory was applied to look for interference of NP with active daily life. Preoperative and intraoperative data were analyzed to find the association with the NP. The association with causative factors was done using Mann\u2013Whitney U test for continuous measures and Pearson\u2019s Chi-squared test\/Fischer\u2019s test for categorical variables.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Of total 278 patients, the incidence of NP was 23.5% (n = 65) at the third postoperative day, 12.6% (n = 35) at 1 month, and 3.6% (n = 10) at 3 months. We found a significant correlation of NP with age (\n P<\/jats:italic>\n = 0.05), preoperative ongoing treatment for NP (\n P<\/jats:italic>\n = 0.01), preoperative pain severity (\n P<\/jats:italic>\n = 0.005), type of surgery (\n P<\/jats:italic>\n < 0.001), region operative (\n P<\/jats:italic>\n = 0.01), intraoperative nerve handling (\n P<\/jats:italic>\n < 0.01), and reconstruction component (\n P<\/jats:italic>\n = 0.02).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n The incidence of postoperative NP is high [23.5%] in young adults, patients with pre-existing NP controlled with medication, preoperative pain severity, reconstructive component of surgery, and nerve handling. Certain surgeries like amputation, pelvis tumors, and plastic reconstructions are associated with a higher incidence of NP.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/joacp.joacp_8_25","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:00:38Z","timestamp":1774440038000},"page":"222-228","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A prospective observational study to assess the incidence of neuropathic pain after bone and soft tissue cancer surgery"],"prefix":"10.4103","volume":"42","author":[{"given":"Sakshi","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Pediatric Anaesthesiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumitra G.","family":"Bakshi","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Critical Care and Pain, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parmanand","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"R2-20260325","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3233\/NRE-208002","article-title":"Peripheral neuropathic pain","volume":"47","author":"Murphy","year":"2020","journal-title":"Neurorehabilitation"},{"key":"R3-20260325","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/papr.12291","article-title":"Neuropathic pain components in patients with cancer:Prevalence, treatment, and interference with daily activities","volume":"16","author":"Oosterling","year":"2015","journal-title":"Pain Practice"},{"key":"R4-20260325","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1185\/030079906X132488","article-title":"Paindetect:A new screening questionnaire to identify neuropathic components in patients with back pain","volume":"22","author":"Freynhagen","year":"2006","journal-title":"Curr Med Res Opin"},{"key":"R5-20260325","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1111\/papr.12562","article-title":"Neuropathic pain assessment with the paindetect questionnaire:Cross-cultural adaptation and psychometric evaluation to Hindi","volume":"17","author":"Gudala","year":"2017","journal-title":"Pain Practice"},{"key":"R6-20260325","doi-asserted-by":"crossref","first-page":"e10852","DOI":"10.1097\/MD.0000000000010852","article-title":"Neuropathic pain after sarcoma surgery","volume":"97","author":"Park","year":"2018","journal-title":"Medicine"},{"key":"R7-20260325","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/S1470-2045(09)70114-7","article-title":"The brief pain inventory:Revealing the effect of cancer pain","volume":"10","author":"Bennett","year":"2009","journal-title":"Lancet Oncol"},{"key":"R8-20260325","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1186\/s12889-020-09208-0","article-title":"Age differences in demographic, social and health-related factors associated with loneliness across the adult life span (19\u201365 years):A cross-sectional study in the Netherlands","volume":"20","author":"Franssen","year":"2020","journal-title":"BMC Public Health"},{"key":"R10-20260325","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0304-3959(94)00178-H","article-title":"When is cancer pain mild, moderate or severe?grading pain severity by its interference with function","volume":"61","author":"Serlin","year":"1995","journal-title":"Pain"},{"key":"R11-20260325","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4103\/0019-5049.126788","article-title":"Prevalence of acute neuropathic pain after cancer surgery:A prospective study","volume":"58","author":"Jain","year":"2014","journal-title":"Indian J Anaesth"},{"key":"R12-20260325","article-title":"Prospective study of neuropathic pain after definitive surgery for extremity osteosarcoma in a pediatric population","volume":"64","author":"Anghelescu","year":"2016","journal-title":"Pediatr Blood Cancer"},{"key":"R13-20260325","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3109\/17453674.2014.987065","article-title":"Persistent pain is common 1\u20132 years after shoulder replacement","volume":"86","author":"Bj\u00f8rnholdt","year":"2014","journal-title":"Acta Orthopaedica"},{"key":"R14-20260325","first-page":"1020","article-title":"Prevalence of persistent pain after total knee arthroplasty and the impact of neuropathic pain","volume":"32","author":"Hasegawa","year":"2018","journal-title":"J Knee Surg"},{"key":"R15-20260325","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.joca.2013.06.023","article-title":"Neuropathic pain symptoms on the modified paindetect correlate with signs of central sensitization in knee osteoarthritis","volume":"21","author":"Hochman","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"R16-20260325","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/EJA.0000000000000634","article-title":"Early postoperative neuropathic pain assessed by the DN4 score predicts an increased risk of persistent postsurgical neuropathic pain","volume":"34","author":"Beloeil","year":"2017","journal-title":"Eur J Anaesthesiol"},{"key":"R17-20260325","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.pain.2012.04.004","article-title":"Risk factors predictive of chronic postsurgical neuropathic pain:The value of the iliac crest bone harvest model","volume":"153","author":"Martinez","year":"2012","journal-title":"Pain"},{"key":"R18-20260325","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1097\/j.pain.0000000000000108","article-title":"Comparing the DN4 tool with the IASP grading system for chronic neuropathic pain screening after breast tumor resection with and without paravertebral blocks","volume":"156","author":"Abdallah","year":"2015","journal-title":"Pain"},{"key":"R19-20260325","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pain.2004.12.010","article-title":"Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4)","volume":"114","author":"Bouhassira","year":"2005","journal-title":"Pain"},{"key":"R20-20260325","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1136\/jnnp-2017-317215","article-title":"Incidence and disease burden of chemotherapy-induced peripheral neuropathy in a population-based cohort","volume":"89","author":"Shah","year":"2018","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["Journal of Anaesthesiology Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/joacp.joacp_8_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:41:55Z","timestamp":1787067715000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/joacp.joacp_8_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,25]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/joacp.joacp_8_25","relation":{},"ISSN":["0970-9185","2231-2730"],"issn-type":[{"value":"0970-9185","type":"print"},{"value":"2231-2730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,25]]},"assertion":[{"value":"2025-01-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-29","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}